Supramolecular self-assembly through inclusion complex formation between poly(ethylene oxide-b-N-isopropylacrylamide) block copolymer and α-cyclodextrin

Tu, Cheng-Wei; Kuo, Shiao‐Wei; Chang, Feng‐Chih

doi:10.1016/j.polymer.2009.04.034

Cited by 36 publications

(24 citation statements)

References 47 publications

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“…The formation of selective complexes from block copolymers has been reported by several research groups. Tu et al reported the formation of α-CD complexes with PEOb-PNIPAM diblock copolymers [13]. Liu et.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a drug carrier through α-cyclodextrin-induced micellization of poly(ε-caprolactone-block-4-vinylpyridine) for controlled delivery of doxorubicin

Chuang

Prasannan³

et al. 2015

J Polym Res

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A novel method has been used to prepare the selfassembled supramolecular micelles which aid in the delivery of anticancer drugs. α-Cyclodextrin (α-CD) induces a micellization process of poly(ε-caprolactone-block-4-vinylpyridine) (PCL-b-P4VP) copolymers through selective inclusion of PCL segments into the cavity of α-CD, resulting in the formation of pseudopolyrotaxane-b-P4VP. Compound pseudopolyrotaxane-b-P4VP forms supramolecular micelles in aqueous medium through self-assembly, which has been characterized using various analytical techniques. The resultant complex micelles consist of pseudopolyrotaxane as the core and P4VP chains in the outer shell, and the micelles possess a well-defined spherical morphology. The selfassembly process can easily be tailor-made by varying the number of PCL and P4VP segments in the PCL x -b-P4VP y copolymer. The arrangement of pseudopolyrotaxane-b-P4VP in the form of Bchannel-type^crystallites (derived from the supramolecular columns) is confirmed from the wide-angle X-ray diffraction (WAXD) patterns as well as by the composition of the inclusion complexes (ICs) calculated via proton nuclear magnetic resonance ( 1 H NMR) spectral data. The biocompatibility of the micelles was evaluated by a cell viability test and the results revealed excellent cytocompatibility. The prepared micelles were used as carriers for the model anticancer drug doxorubicin (DOX) and successful drug release was observed with a loading content of 14.4 % (w/w) and a loading efficiency of 28.9 %. In vitro drug delivery was evaluated in phosphate-buffered saline (PBS) solution. DOX release from the micelles was considerably faster at pH 5.0 in comparison to a physiological pH of 7.4. The development of supramolecular self-assembled micelles based on partial IC formation between α-CD and compatible block copolymers opens a new, facile and attractive approach for designing novel drug carriers for future pharmaceutical applications.

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Section: Introductionmentioning

confidence: 99%

Preparation of a drug carrier through α-cyclodextrin-induced micellization of poly(ε-caprolactone-block-4-vinylpyridine) for controlled delivery of doxorubicin

Chuang

Prasannan³

et al. 2015

J Polym Res

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“…[3] CDs can form different aggregates under different conditions. Many new supramolecular assemblies have been planned, such as supramolecular gels, [4] supramolecular polymers, [5,6] rotaxanes, [7] nanospheres, [8] and vesicles based on CD inclusion complexes. The vesicles prepared by CD inclusion complexes have gained much attention due to their importance in enthusiastic natural biomembranes, [9,10] developing new biotechniques, smart materials, etc.…”

Section: Introductionmentioning

confidence: 99%

Nanochain and vesicles formed by inclusion complexation of 4,4′-diaminobenzanilide with cyclodextrins

Rajendiran

Sankaranarayanan

Saravanan

2014

Journal of Experimental Nanoscience

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The nanochain-like agglomerates and spherical nanovesicles were formed from supramolecular self-assembly of 4,4 0 -diaminonenzanilide (DABA) with a-and b-cyclodextrins. The DABA with a-CD and b-CD inclusion complex nanomaterials were prepared and characterised by transmission electron microscopy, scanning electron microscopy, FTIR, differential scanning calorimetry, 1 H NMR and powder X-ray diffraction. 1 H NMR analysis indicated that the benzamido ring of DABA was encapsulated into the cyclodextrin (CD) cavity. Absorption and fluorescence spectral studies suggested that DABA forms different types of nanomaterials in a-CD and b-CD solutions. Higher occupied molecular orbital, lower unoccupied molecular orbital, and thermodynamic parameter values confirmed DABA dye entrapped in the CD cavities.

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“…In aqueous solutions, water molecules contained in the CD hydrophobic cavity are readily exchanged by a hydrophobic guest molecule of the right size and geometry resulting in an inclusion guest-host complex. 12 This guest-host relationship is driven by different interactions like hydrophobic interaction, van der Waals force and hydrogen bonding. [13][14][15] The formation of guest-host complexes leads to a boost of the solubility of the guest molecules.…”

Section: Introductionmentioning

confidence: 99%

Nanoporous cyclodextrin-based co-polymeric microspheres for encapsulation of active components

Mathapa

Paunov

2013

J. Mater. Chem. B

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We have fabricated nanoporous polyallylamine hydrochloride (PAH)-cyclodextrin co-polymeric microspheres using epichlorohydrin as a cross-linking agent. The structure and morphology of the microspheres were studied by optical and electron microscopy and FT-IR spectrometry was used to confirm the presence of cyclodextrin in the co-polymer. The encapsulating capability of these molecularly porous microspheres was tested by loading them with two fluorescing dyes whose localization within the microspheres was examined by Laser Scanning Confocal Microscopy (LSM). We tested the capacity of the microspheres to remove surfactants such as cetyltrimethyl ammonium bromide (CTAB), Sodium Dodecyl Sulphate (SDS) and organic dyes like Indophenol Blue from aqueous solutions. These results were confirmed using surface tension measurements and UV-vis spectroscopy. The CD-copolymeric microspheres showed significant capacity for encapsulation of molecules of varying polarities and different hydrophobicities, which makes them attractive for applications in a wide range of areas such as agrochemicals, water purification, pharmaceuticals, drug delivery, separation science and cosmetics.

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Supramolecular self-assembly through inclusion complex formation between poly(ethylene oxide-b-N-isopropylacrylamide) block copolymer and α-cyclodextrin

Cited by 36 publications

References 47 publications

Preparation of a drug carrier through α-cyclodextrin-induced micellization of poly(ε-caprolactone-block-4-vinylpyridine) for controlled delivery of doxorubicin

Preparation of a drug carrier through α-cyclodextrin-induced micellization of poly(ε-caprolactone-block-4-vinylpyridine) for controlled delivery of doxorubicin

Nanochain and vesicles formed by inclusion complexation of 4,4′-diaminobenzanilide with cyclodextrins

Nanoporous cyclodextrin-based co-polymeric microspheres for encapsulation of active components

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