Supramolecular self-assembly of novel thermo-responsive double-hydrophilic and hydrophobic Y-shaped [MPEO-b-PEtOx-b-(PCL)<sub>2</sub>] terpolymers

Petrova, Svetlana; Venturini, Cristina G.; Jäger, Alessandro; Jäger, Eliézer; Hrubý, Martin; Pavlová, Ewa; Štěpánek, Petr

doi:10.1039/c5ra08298f

Cited by 6 publications

(5 citation statements)

References 72 publications

(103 reference statements)

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“…Synthesis strategies for Y-shaped AB 2 miktoarm polymers include atom transfer radical polymerization (ATRP), 35,36 opening polymerization (ROP), [37][38][39] and "click" reaction 40 as well as versatile combinations of different polymerization methods, including ATRP/ROP, 41,42 reversible addition-fragmentation chain transfer (RAFT) polymerization/ROP, 43 ROP/click, 44 ATRP/ ROP/click, 45 living cationic polymerization/ROP, and anionic polymerization/ROP combination. 46,47 Meanwhile, self-assembly of Y-shaped AB 2 miktoarm polymers in solution also has been investigated in detail. Experimental results showed that selfassembly in solution of Y-shaped AB 2 miktoarm polymers is different from that of their linear counterparts.…”

Section: Introductionmentioning

confidence: 99%

Dual responsive macroemulsion stabilized by Y-shaped amphiphilic AB₂ miktoarm star copolymers

Yang

Gao

et al. 2015

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Dual responsive macroemulsion stabilized by Y-shaped amphiphilic AB₂ miktoarm star copolymers

Yang

Gao

et al. 2015

RSC Adv.

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“…The paclitaxel release is sustained in all tested conditions; however, it is substantially accelerated at temperatures of 37 (>90% released in 48 h) and 40 • C (>90% released in 24 h) when compared to 25 • C (>80% released in 48 h). These results suggest that at temperatures closer to the LCST (37 • C), the BC3 NPs start to become physically destabilized (temperature-triggered activation-de-swelling aggregation) [75,76], thus accelerating the release of the anticancer drug. This effect is most pronounced at a temperature above the LCST, where the PTX is released completely within the first 24 h at 40 • C, mimicking, for instance, temperatures in the range used for hyperthermia treatment [46,77].…”

Section: Paclitaxel-loaded Bc3 Nanoparticles and Paclitaxel Releasementioning

confidence: 95%

Smart Poly(lactide)-b-poly(triethylene glycol methyl ether methacrylate) (PLA-b-PTEGMA) Block Copolymers: One-Pot Synthesis, Temperature Behavior, and Controlled Release of Paclitaxel

et al. 2023

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This paper introduces a new class of amphiphilic block copolymers created by combining two polymers: polylactic acid (PLA), a biocompatible and biodegradable hydrophobic polyester used for cargo encapsulation, and a hydrophilic polymer composed of oligo ethylene glycol chains (triethylene glycol methyl ether methacrylate, TEGMA), which provides stability and repellent properties with added thermo-responsiveness. The PLA-b-PTEGMA block copolymers were synthesized using ring-opening polymerization (ROP) and reversible addition–fragmentation chain transfer (RAFT) polymerization (ROP-RAFT), resulting in varying ratios between the hydrophobic and hydrophilic blocks. Standard techniques, such as size exclusion chromatography (SEC) and 1H NMR spectroscopy, were used to characterize the block copolymers, while 1H NMR spectroscopy, 2D nuclear Overhauser effect spectroscopy (NOESY), and dynamic light scattering (DLS) were used to analyze the effect of the hydrophobic PLA block on the LCST of the PTEGMA block in aqueous solutions. The results show that the LCST values for the block copolymers decreased with increasing PLA content in the copolymer. The selected block copolymer presented LCST transitions at physiologically relevant temperatures, making it suitable for manufacturing nanoparticles (NPs) and drug encapsulation-release of the chemotherapeutic paclitaxel (PTX) via temperature-triggered drug release mechanism. The drug release profile was found to be temperature-dependent, with PTX release being sustained at all tested conditions, but substantially accelerated at 37 and 40 °C compared to 25 °C. The NPs were stable under simulated physiological conditions. These findings demonstrate that the addition of hydrophobic monomers, such as PLA, can tune the LCST temperatures of thermo-responsive polymers, and that PLA-b-PTEGMA copolymers have great potential for use in drug and gene delivery systems via temperature-triggered drug release mechanisms in biomedicine applications.

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“…The transformation of living cationic polymerization ‐Ŧ‐ ROP has been reported in 2015 by Petrova et al . This group described a successful three‐step synthesis of double‐hydrophilic and hydrophobic biocompatible triblock terpolymers containing PEO, poly(2‐ethyl‐2‐oxazoline) (PEtOx) and poly(ε‐caprolactone) (PCL) segments by a combination of living cationic polymerization and anionic ring opening polymerization (ROP).…”

Section: Transformations From Living Cationic Polymerizationmentioning

confidence: 99%

Polymer Synthesis with More Than One Form of Living Polymerization Method

Guo

Choi

Feng

et al. 2018

Macromol. Rapid Commun.

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Controlled radical polymerization (CRP) or controlled/living radical polymerization has revolutionized the polymer industry as a tool for the preparation of a wide variety of polymers. This process enables the preparation of polymers with good control of molecular weight, narrow polydispersity, and a range of architectures including block and graft copolymers, star polymers, and other functional polymers. The mechanistic transformation reaction provides a great opportunity to tune chemical and physical properties of copolymers. It can be applied to combine different homopolymers using post‐modification techniques or by the use of a dual initiator, allowing the combination of mechanistically distinct polymerization reactions. This review will cover CRP transformations including the synthesis of block copolymers with both linear structures (AB, ABA, (AB) n , multiblocks, etc.) and branched macromolecular architectures (graft, miktoarm star, and dendritic‐like), which are obtained by a combination of more than one form of living polymerization reaction.

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Supramolecular self-assembly of novel thermo-responsive double-hydrophilic and hydrophobic Y-shaped [MPEO-b-PEtOx-b-(PCL)₂] terpolymers

Abstract: Nonlinear amphiphilic block copolymer architectures with precisely controlled structures bring new challenges to biomedical materials research.

Cited by 6 publications

References 72 publications

Dual responsive macroemulsion stabilized by Y-shaped amphiphilic AB₂ miktoarm star copolymers

Dual responsive macroemulsion stabilized by Y-shaped amphiphilic AB₂ miktoarm star copolymers

Smart Poly(lactide)-b-poly(triethylene glycol methyl ether methacrylate) (PLA-b-PTEGMA) Block Copolymers: One-Pot Synthesis, Temperature Behavior, and Controlled Release of Paclitaxel

Polymer Synthesis with More Than One Form of Living Polymerization Method

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Supramolecular self-assembly of novel thermo-responsive double-hydrophilic and hydrophobic Y-shaped [MPEO-b-PEtOx-b-(PCL)2] terpolymers

Abstract: Nonlinear amphiphilic block copolymer architectures with precisely controlled structures bring new challenges to biomedical materials research.

Cited by 6 publications

References 72 publications

Dual responsive macroemulsion stabilized by Y-shaped amphiphilic AB2 miktoarm star copolymers

Dual responsive macroemulsion stabilized by Y-shaped amphiphilic AB2 miktoarm star copolymers

Smart Poly(lactide)-b-poly(triethylene glycol methyl ether methacrylate) (PLA-b-PTEGMA) Block Copolymers: One-Pot Synthesis, Temperature Behavior, and Controlled Release of Paclitaxel

Polymer Synthesis with More Than One Form of Living Polymerization Method

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Product

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Supramolecular self-assembly of novel thermo-responsive double-hydrophilic and hydrophobic Y-shaped [MPEO-b-PEtOx-b-(PCL)₂] terpolymers

Dual responsive macroemulsion stabilized by Y-shaped amphiphilic AB₂ miktoarm star copolymers

Dual responsive macroemulsion stabilized by Y-shaped amphiphilic AB₂ miktoarm star copolymers