Supramolecular organogel based on di-Fmoc functionalized unnatural amino acid: An attempt to develop a correlation between molecular structure and ambidextrous gelation

Arokianathan, Jaini Flora; Ramya, Koduvayur A.; Deshpande, Abhijit P.; Leemarose, Ambrose; Shanmugam, Ganesh

doi:10.1016/j.colsurfa.2021.126430

Cited by 7 publications

(7 citation statements)

References 58 publications

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“…However, it is a natural amino acid, [7a] observed in vegetal species, and it was also found in meteorites [7b] . Over the last years, Dap was exploited for a number of applications, such as the construction of an EPR probe for protein studies, [8] of new foldamers, [9] of nucleobase‐decorated peptides, [10] of an organogelator, [11] and, more interestingly, of a cell‐penetrating peptide [12] . However, to the best of our knowledge an in‐depth analysis of the conformational preferences of Dap was never published.…”

Section: Introductionmentioning

confidence: 99%

Conformational Analysis and Through‐Chain Charge Propagation in Ferrocenyl‐Conjugated Homopeptides of 2,3‐Diaminopropionic acid (Dap)

Biondi¹,

Bisello

Cardena

et al. 2022

Eur J Inorg Chem

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This work reports a detailed conformational and electrochemical study of two series of ferrocene (Fc)-peptide conjugates, based on the side-chain protected, 2,3-diaminopropionic acid (LÀ Dap). In one series Fc is linked to the N-terminus, in the other to the C-terminus of the Dap homo-peptides. The conformational analysis carried out in solution (IR absorption and NMR) and in the crystal state (X-ray diffraction) suggests that these peptides adopt a 3 10 -helical structure. Cyclic voltammetry showed that the peptide length positively or negatively affects the oxidation potential of Fc. The two opposite trends are correlated to the different orientation of the macrodipole moment of the 3 10 -helix in the two series with respect to the position of the Fc group in the chain. Finally, the variation of the IR absorptions upon chemical oxidation indicates that our 3 10 -helical conjugates are very efficient in transferring the positive charge along the peptides through the H-bond network.

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Section: Introductionmentioning

confidence: 99%

Conformational Analysis and Through‐Chain Charge Propagation in Ferrocenyl‐Conjugated Homopeptides of 2,3‐Diaminopropionic acid (Dap)

Biondi¹,

Bisello

Cardena

et al. 2022

Eur J Inorg Chem

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“…Four molecules do not self-assemble in long and high aspect ratio objects as the main population. As a result, they do not support the formation of gels (2,14,15,19). The results are summarized in Table 1 and in Figures 1-2-3 for each polar head.…”

Section: -Thermal Gelationmentioning

confidence: 81%

Wet spinning of a library of carbohydrate low molecular weight gels

Bordignon

Lonetti

Coudret

et al. 2021

Journal of Colloid and Interface Science

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“…Thixotropic property can be examined with the help of different techniques. The most common classic procedure is the three intervals thixotropic test (3ITT), in which three zones were created in the whole cycle with “OFF–ON–OFF” modes [ 14 , 15 , 16 ]. In the first cycle (OFF state), a low strain is applied, i.e., within the linear viscoelastic region (LVR) [ 10 , 11 ] in which storage modulus (G′) is higher than loss modulus (G″) [ 11 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…G′ and G″ are the most critical rheological parameters and are generally employed to dictate the viscoelastic character of gels. G′ value is always greater than G″ value for an ideal gel system, but the inverse phenomenon is noticed when the gels undergo liquefaction [ 14 , 18 ]. In the last step of the cycle (OFF state), the same parameters are used as in the first cycle to restore the gel state.…”

Section: Introductionmentioning

confidence: 99%

Short Peptide-Based Smart Thixotropic Hydrogels

Pramanik

2022

Gels

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Thixotropy is a fascinating feature present in many gel systems that has garnered a lot of attention in the medical field in recent decades. When shear stress is applied, the gel transforms into sol and immediately returns to its original state when resting. The thixotropic nature of the hydrogel has inspired scientists to entrap and release enzymes, therapeutics, and other substances inside the human body, where the gel acts as a drug reservoir and can sustainably release therapeutics. Furthermore, thixotropic hydrogels have been widely used in various therapeutic applications, including drug delivery, cornea regeneration and osteogenesis, to name a few. Because of their inherent biocompatibility and structural diversity, peptides are at the forefront of cutting-edge research in this context. This review will discuss the rational design and self-assembly of peptide-based thixotropic hydrogels with some representative examples, followed by their biomedical applications.

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Supramolecular organogel based on di-Fmoc functionalized unnatural amino acid: An attempt to develop a correlation between molecular structure and ambidextrous gelation

Cited by 7 publications

References 58 publications

Conformational Analysis and Through‐Chain Charge Propagation in Ferrocenyl‐Conjugated Homopeptides of 2,3‐Diaminopropionic acid (Dap)

Conformational Analysis and Through‐Chain Charge Propagation in Ferrocenyl‐Conjugated Homopeptides of 2,3‐Diaminopropionic acid (Dap)

Wet spinning of a library of carbohydrate low molecular weight gels

Short Peptide-Based Smart Thixotropic Hydrogels

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