Supramolecular Nanotube Architectures Based on Amphiphilic Molecules

Shimizu, Toshimi; Masuda, Mitsutoshi; Minamikawa, Hiroyuki

doi:10.1021/cr030072j

Cited by 1,417 publications

(1,108 citation statements)

References 394 publications

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“…The hydrolyzed product diacetylene acid (DA) has been well reported to form vesicular aggregation in aqueous solution 29, 30, 31. According to the calculation of critical packing parameter (CPP),32 DA with a CPP value of 0.94 prefers to form spherical vesicle while DC with a CPP value of 0.33 prefers to form spherical (or cylindrical) micelle 33. However, DA cannot be well hydrated in HEPES buffer even with harsh sonication at 80 °C for 30 min owing to its poor water solubility.…”

Section: Resultsmentioning

confidence: 99%

Sequentially Programmable and Cellularly Selective Assembly of Fluorescent Polymerized Vesicles for Monitoring Cell Apoptosis

et al. 2017

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The introduction of controlled self‐assembly into living organisms opens up desired biomedical applications in wide areas including bioimaging/assays, drug delivery, and tissue engineering. Besides the enzyme‐activated examples reported before, controlled self‐assembly under integrated stimuli, especially in the form of sequential input, is unprecedented and ultimately challenging. This study reports a programmable self‐assembling strategy in living cells under sequentially integrated control of both endogenous and exogenous stimuli. Fluorescent polymerized vesicles are constructed by using cholinesterase conversion followed by photopolymerization and thermochromism. Furthermore, as a proof‐of‐principle application, the cell apoptosis involved in the overexpression of cholinesterase in virtue of the generated fluorescence is monitored, showing potential in screening apoptosis‐inducing drugs. The approach exhibits multiple advantages for bioimaging in living cells, including specificity to cholinesterase, red emission, wash free, high signal‐to‐noise ratio.

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Section: Resultsmentioning

confidence: 99%

Sequentially Programmable and Cellularly Selective Assembly of Fluorescent Polymerized Vesicles for Monitoring Cell Apoptosis

et al. 2017

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“…3). In spite of the extensive theoretical and experimental work [36][37][38][39], several questions remain to be answered about the mechanism or pathway involved in the tube formation. However, the driving…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of nanoarchitectures from fatty acid derivatives of 2,6-diaminopyridine and 2-aminopyridine

Hassan

Rauf

2014

J Nanostruct Chem

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The self-assembling property of lipids makes it an important building block in the field of supramolecular nanoarchitectures with a variety of applications in chemistry, biochemistry, materials science and medicine. We report here, the synthesis and formation of variety of nanostructures such as nanosheets, nanofibers and nanotubes of fatty acid derivatives of 2,6-diaminopyridine and 2-aminopyridine. These molecules possess a saturated or unsaturated long alkyl-chain group as the self-assembling unit. The molecular recognition property of diaminopyridine linker as a result of H-bonding was confirmed by 1 H-NMR and fluorescence spectroscopy and it plays an important role in monitoring the chemical selectivity of supramolecular aggregates toward guest binding. The chemical structures were characterized by Fourier transform-infrared, 1 H-NMR, 13 C-NMR, mass spectra, whereas the morphologies were imaged using scanning electron microscopy and transmission electron microscopy.

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“…Although lipid packing parameters may play a role in nanotube formation, 10,11 in cell biology the process is dynamic and localized, which suggests that either an interfacial interaction actuates the event or mechanical activity promotes membrane deformation. 12 Protein-membrane interactions can induce membrane nanotube formation through the protein's structure, such as with the banana shape of amphiphysin, 13 or through protein assemblies with dynamin 14 and endophilin, 15 or even by simply altering the surface charge of the membrane.…”

Section: Introductionmentioning

confidence: 99%

Biomolecular transport and separation in nanotubular networks.

Stachowiak¹,

Stevens

Robinson³

et al. 2010

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Cell membranes are dynamic substrates that achieve a diverse array of functions through multi-scale reconfigurations. We explore the morphological changes that occur upon protein interaction to model membrane systems that induce deformation of their planar structure to yield nanotube assemblies. In the two examples shown in this report we will describe the use of membrane adhesion and particle trajectory to form lipid nanotubes via mechanical stretching, and protein adsorption onto domains and the induction of membrane curvature through steric pressure. Through this work the relationship between membrane bending rigidity, protein affinity, and line tension of phase separated structures were examined and their relationship in biological membranes explored.

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Supramolecular Nanotube Architectures Based on Amphiphilic Molecules

Cited by 1,417 publications

References 394 publications

Sequentially Programmable and Cellularly Selective Assembly of Fluorescent Polymerized Vesicles for Monitoring Cell Apoptosis

Sequentially Programmable and Cellularly Selective Assembly of Fluorescent Polymerized Vesicles for Monitoring Cell Apoptosis

Synthesis and characterization of nanoarchitectures from fatty acid derivatives of 2,6-diaminopyridine and 2-aminopyridine

Biomolecular transport and separation in nanotubular networks.

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