Supramolecular Nanoencapsulation as a Tool: Solubilization of the Anticancer Drugtrans-Dichloro(dipyridine)platinum(II) by Complexation with β-Cyclodextrin

Abstract

A novel, water-soluble trans-platinum complex was synthesized by inclusion complexation with beta-cyclodextrin. The complexation was confirmed by (1)H NMR, FT-IR, TGA, and XRD as well as by SEM and EDX. As the precursor complex is not water-soluble, it is difficult to employ it for biological applications. Here, we report that the encapsulation with cyclodextrin allowed to solubilize the complex to a solubility value of 1.6 mg/mL. Moreover, the cytotoxicity in vitro of the novel inclusion complex indicated a much higher activity after encapsulation.

Enhancement of rhubarb extract solubility and bioactivity by 2-hydroxypropyl-β-cyclodextrin

“…This finding was related to the enhanced aqueous solubility of rhubarb molecules when they were complexed with HP-␤-CD (Brewster & Loftsson, 2007). Other hydrophobic drugs, such as curcumin (Yallapu et al, 2010), dichloro(dipyridine)platinum (Horvath et al, 2008), and pyrazolopyrimidines (Botta et al, 2010), have also shown enhanced cellular uptake when complexed with CDs and thus enhancing their cytotoxic effect.…”

Cyclodextrins improve the antimicrobial activity of the chloride salt of Ruthenium(II) chloro-phenanthroline-trithiacyclononane

“…Recent work on CD inclusion of the compounds Cp 2 MCl 2 (Cp = cyclopentadienyl, M = Nb, Mo) (Pereira et al 2007;Braga et al 2005Braga et al , 2001 showed an enhanced antitumoral action, in particular for TRIMEBÁCp 2 MoCl 2 (Braga et al 2005). b-CD was also shown to enhance the cytotoxic activity of trans Pt(dipyridine)Cl 2 by improvement of its aqueous solubility (Horvath et al 2008).…”

Macrocycles as a Tool: A Facile and One‐Pot Synthesis of Silver Nanoparticles Using Cucurbituril Designed for Cancer Therapeutics

“…[6] In addition, we also introduced new techniques to fabricate surfactant-based gold nanoparticles and AgNPs. [7,8] Hence, with this experience and expertise in supramolecular strategies, [3,5,6] macrocyclic materials, [3,9] and nanoparticles, [5-8, 10, 11] we thought of combining them all together to form a new supramolecular macrocycle-based metal nanoparticle in pure aqueous medium that can be used for diverse pivotal biomedical applications. This fundamental thinking directs us to prepare well-dispersed AgNPs by using a macrocycle, namely cucurbit [7]uril, in the presence of sodium hydroxide in aqueous medium at ambient experimental conditions.…”