Supramolecular micelles with dual temperature and redox responses for multi-controlled drug release

Yuan, Weizhong; Zou, Hui; Wen, Guo; Shen, Tianxiang; Ren, Jie

doi:10.1039/c3py00211j

Cited by 34 publications

(27 citation statements)

References 20 publications

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“…On the other hand, it is reported that there are many open and accessible cavities in a rigid hb polymer that are formed due to the periphery of neighboring branches. These cavities may function as the pathways for the transport of gas molecules, resulting in high gas permeability [281][282][283][284][285][286].…”

Section: Membranesmentioning

confidence: 99%

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Porous Carbons – Hyperbranched Polymers – Polymer Solvation

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Voit

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2015

Advances in Polymer Science

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Section: Membranesmentioning

confidence: 99%

“…With biological and medical relevance, chemical redox on thiols or disulfide groups can change the morphology and uptake properties of micelles, vesicles, and dendrimers [281][282][283][284][285][286]. For instance, glutathione allowed the release of disulfide shell-crosslinked micelles [287].…”

Section: Chemical Redox For Self-assembled Systemsmentioning

confidence: 99%

Porous Carbons – Hyperbranched Polymers – Polymer Solvation

Long

Voit

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2015

Advances in Polymer Science

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“…Yuan et al designed the supramolecular micelles with temperature and reduction dual-responses by self-assembling of the polyrotaxane (PRX) of PEG-SSpoly(2-(N,N-dimethylamino)ethyl methacrylate) with α-cyclodextrin (α-CD) (PRX-SS-PDMAEMA) [36]. As shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Synthesis strategies for disulfide bond-containing polymer-based drug delivery system for reduction-responsive controlled release

Liu

2015

Front. Mater. Sci.

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Tumor micro-environment responsive drug delivery systems (DDSs) have been developed as a potential approach to reduce the side effects of cancer chemotherapy. Glutathione (GSH) has been supposed to the most significant signal of the difference between the normal tissue and the tumor cells, besides the media pH and temperature. In recent years, the reduction-responsive DDSs have attracted more and more attention for delivery of anti-cancer drugs, based on such physiological signal. Among them, disulfide bond-containing polymers have been designed as the main tool for the purpose. The recent progress in the synthesis strategies for the disulfide bondcontaining polymer-based DDS is focused in the present review.

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“…[6] Multifunctional nanoparticles offer several distinct advantages including increased transfection efficiency, stimuliresponsiveness, and specific gene delivery. [7] For instance, disulfide-containing gene vectors often exhibit specific responsiveness to GSH, which is overexpressed inside cancer cells, thereby allowing selective gene delivery for the treatment of cancer. [8] Gong and coworkers previously reported that oligoamide strands with S-trityl groups formed high fidelity duplex via complementary multiple hydrogen bonds, and this sequencespecific system was capable of reversibly forming disulfide bonds in the presence of iodine, which offered a useful platform for construction of GSH-responsive, size-tunable supramolecular assemblies for smart drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Glutathione (GSH)‐Responsive Amphiphilic Duplexes and their Application in Gene Delivery

Sun

Liu

et al. 2019

ChemPlusChem

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Oligoamide molecular strands with hydrogen‐bonding sequences DADDAD and guanidine (O‐1) or 1,5,9‐triazacyclododecane ([12]aneN3; O‐2) side chains and oligoamides with hydrogen‐bonding sequences ADAADA and octyl moieties (O‐3), were synthesized. Two duplexes (D‐1 and D‐2) were prepared by conjugating the hydrophilic O‐1 or O‐2 and hydrophobic O‐3 through sequence‐specific hydrogen‐bond association and cross‐linked disulfide bonds. Electrophoresis measurements indicated that O‐1, O‐2, D‐1, and D‐2 were able to completely retard the DNA mobiliy at concentrations of 30, 30, 10, and 20 μM, respectively. Reversible DNA release in O‐1 and O‐2 complexes can be achieved in the presence of heparin sodium, whereas the presence of GSH greatly improved DNA release in D‐1 and D‐2 complexes. The particles formed were in a size range of 50–170 nm with positively charged surfaces. D‐1 and D‐2 transfected pEGFP−N1 into HeLa cells successfully.

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Supramolecular micelles with dual temperature and redox responses for multi-controlled drug release

Cited by 34 publications

References 20 publications

Porous Carbons – Hyperbranched Polymers – Polymer Solvation

Porous Carbons – Hyperbranched Polymers – Polymer Solvation

Synthesis strategies for disulfide bond-containing polymer-based drug delivery system for reduction-responsive controlled release

Synthesis of Glutathione (GSH)‐Responsive Amphiphilic Duplexes and their Application in Gene Delivery

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