Supramolecular micelles as multifunctional theranostic agents for synergistic photodynamic therapy and hypoxia-activated chemotherapy

Huang, Xiaobei; Chen, Tunan; Mu, Ning; Lam, Hou Wang; Sun, Chen; Yue, Ludan; Qian, Cheng; Cheng, Gao; Yuan, Zhen; Wang, Ruibing

doi:10.1016/j.actbio.2021.07.014

Cited by 33 publications

(34 citation statements)

References 23 publications

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“…Because of the O 2 consumption stimulated by PDT, Azo groups in the nanoparticles can be effectively cleaved by overexpressed azoreductase to trigger a faster release of chemotherapeutics in hypoxic microenvironments. Using a similar strategy, Huang et al [ 305 ] developed smart supramolecular micelles to codeliver a photosensitizer and hypoxia-sensitive prodrug to enhance the antitumor effects. Satisfactory cancer cell killing in vitro and vivo demonstrated that the designed micelles not only offered a new platform for the codelivery of therapeutic agents to tumors, but also provided novel ideas for designing and preparing advanced materials for multimodality tumor treatment.…”

Section: Stimuli-responsive Targeting Strategiesmentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced permeability and retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective delivery to the tumor cells utilizing cell surface-specific receptors, the tumor vasculature and antigens with high accuracy and affinity. Additionally, stimuli-responsive nanoplatforms have also been considered as a promising and effective targeting strategy against tumors, as these nanoplatforms maintain their stealth feature under normal conditions, but upon homing in on cancerous lesions or their microenvironment, are responsive and release their cargoes. In this review, we comprehensively summarize the field of active targeting drug delivery systems and a number of stimuli-responsive release studies in the context of emerging nanoplatform development, and also discuss how this knowledge can contribute to further improvements in clinical practice.

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Section: Stimuli-responsive Targeting Strategiesmentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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“…34,35 The exploration of such systems through non-covalent synthesis is gathering tremendous interest due to its low cost and convenient construction manner beyond the molecular level. [36][37][38][39] Host-guest interactions have been employed to improve the uorescence quantum yield of dyes, [40][41][42][43][44][45] inhibit aggregation-caused quenching, 46,47 design the supramolecular uorescent probe, [48][49][50] and to enhance the generation capacity of 1 O 2 for PDT. [51][52][53] However, converting type-II PSs to type-I PSs by the host-guest interaction has not been reported.…”

Section: Introductionmentioning

confidence: 99%

A host–guest strategy for converting the photodynamic agents from a singlet oxygen generator to a superoxide radical generator

2022

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“…Host–Guest chemistry involves well-defined interactions. , For the application in PDT, various host species, such as cyclodextrins (CDs), cucurbit[n]urils, pillar[n]arenes, and calix[n]arenes, have been used as hydrophilic carriers for photosensitizers, helping to enhance their solubility in aqueous media and improve their photosensitizing property. , Because of the amphiphilic character, the resulting host–guest complexes can also form self-assembled nano-photosensitizing systems in aqueous media. Host–Guest systems of various classes of photosensitizers, including porphyrins, − pyrophaeophorbide a, chlorin e6, − boron dipyrromethenes (BODIPYs), and phthalocyanines, have been reported for antitumoral or antimicrobial applications. By using a linker that can be cleaved by cancer-related biomarkers (e.g., glutathione and cathepsin B) to connect the supramolecular components, selective activation can be achieved via a stimuli-triggered disassembly of the self-assembled host–guest systems. ,, It is worth noting that the dynamic host–guest complexes can be disassembled via a competitive displacement of the guest species.…”

Section: Introductionmentioning

confidence: 99%

Site-Specific Displacement-Driven Activation of Supramolecular Photosensitizing Nanoassemblies for Antitumoral Photodynamic Therapy

Xue

Yang

Fong

et al. 2022

ACS Appl. Mater. Interfaces

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The delivery and activation of photosensitizers in a specific manner is crucial in photodynamic therapy. For an antitumoral application, it can confine the photodynamic action on the cancer cells, thereby enhancing the treatment efficacy and reducing the side effects. We report herein a novel supramolecular photosensitizing nanosystem that can be specifically activated in cancer cells and tumors that overexpress epidermal growth factor receptor (EGFR). It involves the self-assembly of the amphiphilic host−guest complex of a β-cyclodextrin-conjugated phthalocyanine-based photosensitizer (Pc-CD) and a ferrocene-substituted poly(ethylene glycol) (Mn = 2000) (Fc-PEG) in aqueous media. The resulting nanosystem Pc-CD@Fc-PEG with a hydrodynamic diameter of 124−147 nm could not emit fluorescence and generate reactive oxygen species due to the self-quenching effect and the ferrocene-based quencher. Upon interactions with molecules of adamantane substituted with an EGFRtargeting peptide (Ad-QRH*) in water and in EGFR-positive HT29 and A431 cells, the ferrocene guest species were displaced, resulting in disassembly of the nanoparticles and restoration of these photoactivities. The half-maximal inhibitory concentration values were down to 1.24 μM (for HT29 cells). The nanosystem Pc-CD@Fc-PEG could also be activated in an Ad-QRH*-treated HT29 tumor in nude mice, leading to increased intratumoral fluorescence intensity and effective eradication of the tumor upon laser irradiation. The results showed that this two-step supramolecular approach can actualize site-specific photosensitization and minimize nonspecific phototoxicity in a general photodynamic treatment.

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Supramolecular micelles as multifunctional theranostic agents for synergistic photodynamic therapy and hypoxia-activated chemotherapy

Cited by 33 publications

References 23 publications

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

A host–guest strategy for converting the photodynamic agents from a singlet oxygen generator to a superoxide radical generator

Site-Specific Displacement-Driven Activation of Supramolecular Photosensitizing Nanoassemblies for Antitumoral Photodynamic Therapy

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