Supramolecular micellar drug delivery system based on multi-arm block copolymer for highly effective encapsulation and sustained-release chemotherapy

Zhang, Li; Shi, Dongjian; Shi, Chunling; Kaneko, Tatsuo; Chen, Mingqing

doi:10.1039/c9tb01221d

Cited by 18 publications

(11 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The other polymers that are promising to be utilized as building blocks for drug nanocarrier construction is poly(phosphoesters) due to their good biocompatibility [80,81]. The phosphorus atom in poly(phosphoesters) allows for modification with a number of drug reagents, such as small molecular drugs and protein therapeutics.…”

Section: Poly(phosphoesters)mentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanosystems for Controlled Drug Delivery

2021

View full text Add to dashboard Cite

Biocompatible nanosystems based on polymeric materials are promising drug delivery nanocarrier candidates for antitumor therapy. However, the efficacy is unsatisfying due to nonspecific accumulation and drug release of the nanoparticles in normal tissue. Recently, the nanosystems that can be triggered by tumor-specific stimuli have drawn great interest for drug delivery applications due to their controllable drug release properties. In this review, various polymers and external stimuli that can be employed to develop stimuli-responsive polymeric nanosystems are discussed, and finally, we delineate the challenges in designing this kind of Nanomedicine to improve the therapeutic efficacy.

show abstract

Section: Poly(phosphoesters)mentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanosystems for Controlled Drug Delivery

2021

View full text Add to dashboard Cite

show abstract

“…Not only do these SCKs exhibit considerably prolonged drug release half-life times, additionally, the presence of unreacted triple bonds in the shell allow for further possible modification sites and developments toward targeting and theranostic compounds [53]. Finally, a noteworthy combination of different architectural approaches unites a dendrimer-like secondary structure with self-assembly into micellar tertiary structures [122]. A trivalent block copolymer consisting of poly(amido amine) (PAMAM) as the dendritic core followed by segments of hydrophobic poly(2-butenyl phospholane) (PBEP) and hydrophilic poly(2-methoxy phospholane) (PMP), synthesized via ROP, results in a dendrimer-like structure, as shown in Figure 28.…”

Section: Self-assembling Nanoparticles: Micelles and Polymersomesmentioning

confidence: 99%

“…These supramolecular carriers allow for a multi-step drug release-minimizing primary leakage in the bloodstream affected by the diluted environment. When capped with folic acid (FA) as a targeting agent, they demonstrate high tumor suppression alongside low body toxicity [122].…”

Section: Self-assembling Nanoparticles: Micelles and Polymersomesmentioning

confidence: 99%

Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications

Strasser

Teasdale

2020

Molecules

View full text Add to dashboard Cite

Polymers in which phosphorus is an integral part of the main chain, including polyphosphazenes and polyphosphoesters, have been widely investigated in recent years for their potential in a number of therapeutic applications. Phosphorus, as the central feature of these polymers, endears the chemical functionalization, and in some cases (bio)degradability, to facilitate their use in such therapeutic formulations. Recent advances in the synthetic polymer chemistry have allowed for controlled synthesis methods in order to prepare the complex macromolecular structures required, alongside the control and reproducibility desired for such medical applications. While the main polymer families described herein, polyphosphazenes and polyphosphoesters and their analogues, as well as phosphorus-based dendrimers, have hitherto predominantly been investigated in isolation from one another, this review aims to highlight and bring together some of this research. In doing so, the focus is placed on the essential, and often mutual, design features and structure–property relationships that allow the preparation of such functional materials. The first part of the review details the relevant features of phosphorus-containing polymers in respect to their use in therapeutic applications, while the second part highlights some recent and innovative applications, offering insights into the most state-of-the-art research on phosphorus-based polymers in a therapeutic context.

show abstract

“…Several methods have already been used for providing sustained or controlled release polymeric drug delivery systems, such as polymer encapsulation and polymer bound drug systems [4,7]. However, there is still a need towards developing more controlled and even tailored release profiles.…”

Section: Introductionmentioning

confidence: 99%

Polymeric drug delivery systems by additive manufacturing

Borandeh

Bochove

Teotia

et al. 2021

Advanced Drug Delivery Reviews

113

View full text Add to dashboard Cite

Additive manufacturing (AM) is gaining interests in drug delivery applications, offering innovative opportunities for the design and development of systems with complex geometry and programmed controlled release profile. In addition, polymer-based drug delivery systems can improve drug safety, efficacy, patient compliance, and are the key materials in AM. Therefore, combining AM and polymers can be beneficial to overcome the existing limitations in the development of controlled release drug delivery systems. Considering these advantages, here we are focusing on the recent developments in the field of polymeric drug delivery systems prepared by AM. This review provides a comprehensive overview on a holistic polymer-AM perspective for drug delivery systems with discussion on the materials, properties, design and fabrication techniques and the mechanisms used to achieve a controlled release system. The current challenges and future perspectives for personalized medicine and clinical use of these systems are also briefly discussed.

show abstract

Supramolecular micellar drug delivery system based on multi-arm block copolymer for highly effective encapsulation and sustained-release chemotherapy

Abstract: A novel multi-arm polyphosphoester-based nanomaterial provides high drug loading efficiency and sustained-release drug delivery for effective chemotherapy.

Cited by 18 publications

References 42 publications

Stimuli-Responsive Polymeric Nanosystems for Controlled Drug Delivery

Stimuli-Responsive Polymeric Nanosystems for Controlled Drug Delivery

Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications

Polymeric drug delivery systems by additive manufacturing

Contact Info

Product

Resources

About