Supramolecular Integration of Multifunctional Nanomaterial by Mannose-Decorated Azocalixarene with Ginsenoside Rb1 for Synergistic Therapy of Rheumatoid Arthritis

Li, Shihui; Li, Juan-Juan; Zhao, Ying-Ying; Chen, Meng-Meng; Su, Shan-Shan; Yao, Shun-Yu; Wang, Ze-Han; Hu, Xin-Yue; Geng, Wen-Chao; Wang, Wei; Wang, Ke-Rang; Guo, Dong-Sheng

doi:10.1021/acsnano.3c09140

Cited by 6 publications

(1 citation statement)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our work on the construction of multifunctional materials using amphiphilic calixarenes for the treatment of rheumatoid arthritis serves as a testament to this point. 136 …”

Section: Discussionmentioning

confidence: 99%

Supramolecular interaction in the action of drug delivery systems

Geng,

Jiang,

Chen

et al. 2024

Chem. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our work on the construction of multifunctional materials using amphiphilic calixarenes for the treatment of rheumatoid arthritis serves as a testament to this point. 136 …”

Section: Discussionmentioning

confidence: 99%

Supramolecular interaction in the action of drug delivery systems

Geng,

Jiang,

Chen

et al. 2024

Chem. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

Co‐Assembled Nanoparticles toward Multi‐Target Combinational Therapy of Alzheimer's Disease by Making Full Use of Molecular Recognition and Self‐Assembly

Li,

Xu,

Wang

et al. 2024

Advanced Materials

Self Cite

View full text Add to dashboard Cite

The complex pathologies in Alzheimer's disease (AD) severely limits the effectiveness of single‐target pharmic interventions, thus necessitating multi‐pronged therapeutic strategies. While flexibility is essentially demanded in constructing such multi‐target systems, for achieving optimal synergies and also accommodating the inherent heterogeneity within AD. Utilizing the dynamic reversibility of supramolecular strategy for conferring sufficient tunability in component substitution and proportion adjustment, amphiphilic calixarenes are poised to be a privileged molecular tool for facilely achieving function integration. Herein, taking β‐amyloid (Aβ) fibrillation and oxidative stress as model combination pattern, we proposed a supramolecular multifunctional integration by co‐assembling guanidinium‐modified calixarene with ascorbyl palmitate and loading dipotassium phytate within calixarene cavity. Serial pivotal events can be simultaneously addressed by this versatile system, including (1) inhibition of Aβ production and aggregation, (2) disintegration of Aβ fibrils, (3) acceleration of Aβ metabolic clearance, and (4) regulation of oxidative stress, which is verified to significantly ameliorate the cognitive impairment of 5×FAD mice, with reduced Aβ plaque content, neuroinflammation and neuronal apoptosis. Confronted with the extremely intricate clinical realities of AD, the strategy presented here exhibits ample adaptability for necessary alterations on combinations, thereby may immensely expedite the advancement of AD combinational therapy through providing an exceptionally convenient platform.This article is protected by copyright. All rights reserved

show abstract