Supramolecular hydrogels based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties

Forero-Doria, Oscar; Polo-Cuadrado, Efraín; Maricán, Adolfo; Guzmán, Luís; Venegas, Bernardo; Vijayakumar, Sekar; Wehinger, Sergio; Guerrero, Marcelo; Gallego, Jaime; Durán-Lara, Esteban F.

doi:10.1016/j.carbpol.2020.116383

Cited by 56 publications

(34 citation statements)

References 47 publications

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“…It was concluded that resveratrol included hydrogel formulations could potentially be used in complex wound structures. 62 Also in this study, resveratrol containing hydrogels exhibited improved cell viability and adhesion properties.…”

Section: Resultssupporting

confidence: 60%

Synthesis and characterization of levan hydrogels and their use for resveratrol release

Selvi

Hasköylü

Genç

et al. 2021

Journal of Bioactive and Compatible Polymers

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Considering the need for systematic studies on levan based hydrogels to widen their use in drug delivery systems and biomedical applications, this study is mainly focused on the synthesis and comprehensive characterization as well as drug release properties of hydrogels based on Halomonas levan (HL) and its chemical derivatives. For this, hydrolyzed and phosphonated HL derivatives were chemically synthesized and then cross-linked with 1,4-Butanediol diglycidyl ether (BDDE) and the obtained hydrogels were characterized in terms of their swelling, adhesivity, and rheological properties. Both native and phosphonated HL hydrogels retained their rigid gel like structure with increasing shear stress levels and tack test analysis showed superior adhesive properties of the phosphonated HL hydrogels. Moreover, hydrogels were loaded with resveratrol and entrapment and release studies as well as cell culture studies with human keratinocytes were performed. Biocompatible and adhesive features of the hydrogels confirmed their suitability for tissue engineering and drug delivery applications.

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Section: Resultssupporting

confidence: 60%

Synthesis and characterization of levan hydrogels and their use for resveratrol release

Selvi

Hasköylü

Genç

et al. 2021

Journal of Bioactive and Compatible Polymers

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“…Some studies indicate that the effectivity of antibacterial agents is better when they are applied through sustained release. Furthermore, this approach could lower bacterial resistance incidence [ 7 , 8 , 36 ]. Regarding the limitations presented by PSAH (faster release) and PAAH (reduced mechanical properties), PGAH was selected to carry out the antibacterial analyses.…”

Section: Resultsmentioning

confidence: 99%

“…The studies were performed according to Oscar Forero-Doria et al [ 8 ]. First, 50 mg of each linezolid-loaded hydrogel was placed into a tube with 5 mL of PBS [ 18 ] as “release medium”.…”

Section: Methodsmentioning

confidence: 99%

“…Recent studies indicate that the effectiveness of antibacterial agents is better when they are released through drug delivery systems. Furthermore, these systems could slow down the progression of bacterial resistance to antibiotics [ 7 , 8 ]. In this context, hydrogels appear to be excellent candidates as antibiotic delivery platforms [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

et al. 2020

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A series of hydrogels with a specific release profile of linezolid was successfully synthesized. The hydrogels were synthesized by cross-linking polyvinyl alcohol (PVA) and aliphatic dicarboxylic acids, which include succinic acid (SA), glutaric acid (GA), and adipic acid (AA). The three crosslinked hydrogels were prepared by esterification and characterized by equilibrium swelling ratio, infrared spectroscopy, thermogravimetric analysis, mechanical properties, and scanning electron microscopy. The release kinetics studies of the linezolid from prepared hydrogels were investigated by cumulative drug release and quantified by chromatographic techniques. Mathematical models were carried out to understand the behavior of the linezolid release. These data revealed that the sustained release of linezolid depends on the aliphatic dicarboxylic acid chain length, their polarity, as well as the hydrogel crosslinking degree and mechanical properties. The in vitro antibacterial assay of hydrogel formulations was assessed in an Enterococcus faecium bacterial strain, showing a significant activity over time. The antibacterial results were consistent with cumulative release assays. Thus, these results demonstrated that the aliphatic dicarboxylic acids used as crosslinkers in the PVA hydrogels were a determining factor in the antibiotic release profile.

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“…With the flexible polymer networks, hydrogels are considered to be of great potential in wound dressing and drug delivery because of their porous structure and high water content similar to biological tissues 81 . In addition, the drug release system formed by hydrogels can further realize the drug controlled release and targeted release due to its responsiveness to environmental stimuli such as temperature, pH, chemicals, electric and magnetic fields 82,83 . The loaded drugs in the hydrogels could be released through the change of swelling and shrinkage property.…”

Section: Properties and Applicationsmentioning

confidence: 99%

Cellulose‐based hydrogels regulated by supramolecular chemistry

Zeng

Sun

et al. 2021

SusMat

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Supramolecular hydrogels based on cellulose attract increasing attention because of their novel structures and broad potential applications. In this review, hydrogels composed of cellulose are summarized according to category of supramolecular interactions in the networks including hydrogen bonds, electrostatic interactions, host‐guest interactions, and others. Supramolecular cellulose‐based hydrogels constructed by noncovalent bonding usually exhibit environmental friendliness, designing flexibility and diverse functions, and their properties are variable with incorporating different interactions in hydrogel networks. Moreover, with proper structures and networks, the supramolecular cellulose‐based hydrogels are adaptable in diverse fields of research and practical applications, such as self‐healing, shape memory, drug delivery, and some other renewable/sustainable materials. The future developments and challenges of the supramolecular hydrogels based on cellulose are discussed as well.

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Supramolecular hydrogels based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties

Cited by 56 publications

References 47 publications

Synthesis and characterization of levan hydrogels and their use for resveratrol release

Synthesis and characterization of levan hydrogels and their use for resveratrol release

Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

Cellulose‐based hydrogels regulated by supramolecular chemistry

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