Supramolecular hydrogel based on L-cysteine and silver nanoparticles

Baranova, O. A.; Khizhnyak, S. D.; Пахомов, П. М.

doi:10.1134/s0022476614010296

Cited by 10 publications

(4 citation statements)

References 3 publications

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“…Further studies found that the hydrogel exhibits antibacterial properties. 487 Odriozola et al designed two N-terminal-capped tripeptides, Ac-RGC and Ac-RCG, which have an isoelectric point close to 7. Because these two peptides contain the cysteine residue, they form hydrogels upon the introduction of Au(I) to Ac-RGC and Ag(I) to Ac-RCG, at final peptide concentrations of about ∼3 wt %.…”

Section: Molecular Designmentioning

confidence: 99%

“…Via sulfur–silver bonds, complex 182 self-assembles to form nanofibers and results in hydrogelation at a rather low concentration (0.01 wt %). Further studies found that the hydrogel exhibits antibacterial properties . Odriozola et al designed two N-terminal-capped tripeptides, Ac-RGC and Ac-RCG, which have an isoelectric point close to 7.…”

Section: Molecular Designmentioning

confidence: 99%

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Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

et al. 2015

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In this review we intend to provide a relatively comprehensive summary of the work of supramolecular hydrogelators after 2004 and to put emphasis particularly on the applications of supramolecular hydrogels/hydrogelators as molecular biomaterials. After a brief introduction of methods for generating supramolecular hydrogels, we discuss supramolecular hydrogelators on the basis of their categories, such as small organic molecules, coordination complexes, peptides, nucleobases, and saccharides. Following molecular design, we focus on various potential applications of supramolecular hydrogels as molecular biomaterials, classified by their applications in cell cultures, tissue engineering, cell behavior, imaging, and unique applications of hydrogelators. Particularly, we discuss the applications of supramolecular hydrogelators after they form supramolecular assemblies but prior to reaching the critical gelation concentration because this subject is less explored but may hold equally great promise for helping address fundamental questions about the mechanisms or the consequences of the self-assembly of molecules, including low molecular weight ones. Finally, we provide a perspective on supramolecular hydrogelators. We hope that this review will serve as an updated introduction and reference for researchers who are interested in exploring supramolecular hydrogelators as molecular biomaterials for addressing the societal needs at various frontiers.

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Section: Molecular Designmentioning

confidence: 99%

Section: Molecular Designmentioning

confidence: 99%

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

et al. 2015

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“…We obtained hydrogels using a simple methodology by direct mixing of all components. To prepare 1 mL of CSS according to the procedure, 17,25,26,[28][29][30] 0.3 mL of Cys was added to 0.325 mL of water and 0.375 mL of AgNO 3 ; the concentration of both initial components is 1 Â 10 À2 M. The sample was stirred after addition of each component. Aqueous solutions of all the initial components were prepared using bidistilled water.…”

Section: Preparation and Characterization Of Samples Based On L-cystementioning

confidence: 99%

“…Using various research methods, 17,[24][25][26][27][28][29][30] we have achieved a considerable advance in understanding self-assembly processes in CSS before and after adding a gel-initiating salt. To understand the role of each functional group in L-cysteine for the formation of spatial gel networks and elucidate the mechanism of gelation in CSS, we study self-assembly processes in L-cysteine and its derivatives which differ from cysteine by functional groups such as SH, NH, NH 2 , CO, C(O)OH and OH (see Table 1).…”

Section: Introductionmentioning

confidence: 99%

Mechanism of gelation in low-concentration aqueous solutions of silver nitrate with l-cysteine and its derivatives

et al. 2017

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We discuss the results of experimental studies of the processes of gelation in aqueous solutions of silver nitrate with l-cysteine and its derivatives. We focus on understanding what determines if these small molecules will self-assemble in water at their extremely low concentration to form a gel. A mechanism of gel formation in a cysteine-silver solution (CSS) is proposed. The analysis of the results indicates that filamentary aggregates of a gel network are formed via interaction of NH and C(O)O groups that belong to neighboring silver mercaptide (SM) aggregates. In turn, formation of sulphur-silver bonds between silver mercaptide molecules is responsible for self-assembling these molecules into SM aggregates which can be considered as supramonomers. Free polar groups located on the surfaces of the aggregates can form hydrogen bonds with water molecules, which explains the unique ability of CSS hydrogels to trap water at low concentrations of low-molecular-weight hydrogelators.

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