Supramolecular host-guest hyaluronic acid hydrogels enhance corneal wound healing through dynamic spatiotemporal effects

Fernandes-Cunha, Gabriella; Jeong, Sang Hoon; Logan, Caitlin; Le, Peter; Mundy, David; Chen, Fang; Chen, Karen M.; Kim, Mungu; Lee, Geon‐Hui; Na, Kyung‐Sun; Hahn, Sei Kwang; Myung, David

doi:10.1016/j.jtos.2021.09.002

Cited by 32 publications

(20 citation statements)

References 44 publications

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“…Hyaluronic acid (HA) has been widely used in ophthalmology [ [27] , [28] , [29] , [30] ]. Besides the versatile applications in regenerative medicine, HA often performs as a superb candidate for repairing corneal defects owing to its excellent transparency [ 17 , [31] , [32] , [33] ]. However, previous reports indicated that HA and its derivatives were not conducive to the adhesion of corneal epithelial and stromal cells, which eventually affected the vision recovery [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Dual-crosslinked regenerative hydrogel for sutureless long-term repair of corneal defect

Shen

Zhao

et al. 2023

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

Dual-crosslinked regenerative hydrogel for sutureless long-term repair of corneal defect

Shen

Zhao

et al. 2023

Bioactive Materials

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“…Although HA provides excellent biocompatibility and transparency for its application in repairing corneal defects, linear HA has low retention time in the cornea and majority of HA crosslinkers have toxic effects. In an effort to develop a non‐toxic HA based corneal wound healing material, non‐covalently crosslinked supramolecular HA‐cyclodextrin and HA‐adamantane hydrogels have been reported 19 . Supramolecular HA hydrogels facilitated adhesion and spreading of encapsulated human corneal epithelial cells (HCEC) ex vivo and improved corneal wound healing in vivo.…”

Section: Ophthalmologymentioning

confidence: 99%

“…These Coll‐pyKC implants also triggered anti‐inflammatory differentiation while suppressing pro‐inflammatory differentiation of human monocytes in culture and restricted human adenovirus propagation showing promise for repair, healing, and regeneration of corneas. Multiple publications have reported on corneal wound healing effects of hyaluronic acid (HA) and chondroitin sulfate (CS) 18,19 . Once daily application of mesenchymal stem cell secretome (MSC‐S) combined with HA/CS enhanced cell proliferation and wound healing after injury to the cornea 18 .…”

Section: Ophthalmologymentioning

confidence: 99%

“…Multiple publications have reported on corneal wound healing effects of hyaluronic acid (HA) and chondroitin sulfate (CS). 18,19 Once daily application of mesenchymal stem cell secretome (MSC-S) combined with HA/CS enhanced cell proliferation and wound healing after injury to the cornea. 18 Further, enhanced cell viability and proliferation, increased rate of re-epithelialization and reduction of scar formation in wound models, and increased expression of CD-44 receptors was observed in MSC-S and CS/HA combinations as compared to MSC-S alone.…”

Section: Corneamentioning

confidence: 99%

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Cell‐instructive biomaterials in tissue engineering and regenerative medicine

Adhikari

Stager

Krebs

2023

J Biomedical Materials Res

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The field of biomaterials aims to improve regenerative outcomes or scientific understanding for a wide range of tissue types and ailments. Biomaterials can be fabricated from natural or synthetic sources and display a plethora of mechanical, electrical, and geometrical properties dependent on their desired application. To date, most biomaterial systems designed for eventual translation to the clinic rely on soluble signaling moieties, such as growth factors, to elicit a specific cellular response. However, these soluble factors are often limited by high cost, convoluted synthesis, low stability, and difficulty in regulation, making the translation of these biomaterials systems to clinical or commercial applications a long and arduous process. In response to this, significant effort has been dedicated to researching cell‐directive biomaterials which can signal for specific cell behavior in the absence of soluble factors. Cells of all tissue types have been shown to be innately in tune with their microenvironment, which is a biological phenomenon that can be exploited by researchers to design materials that direct cell behavior based on their intrinsic characteristics. This review will focus on recent developments in biomaterials that direct cell behavior using biomaterial properties such as charge, peptide presentation, and micro‐ or nano‐geometry. These next generation biomaterials could offer significant strides in the development of clinically relevant medical devices which improve our understanding of the cellular microenvironment and enhance patient care in a variety of ailments.

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“…An excellent supramolecular hydrogel based on β-CD and adamantane for corneal wound healing was well designed by Fernandes-Cunha et al In these the supramolecular hyaluronic acid hydrogel was formed based on the host-guest interaction. Compared to the free hyaluronic acid solution, the supramolecular hyaluronic acid hydrogel had prolonged residence time on the cornea without complication [71]. In similar points of view but with different materials, the design architecture has included supramolecular hydrogels DNA-based which could form gel under physiological conditions and bring a promising candidate for vitreous substitute because is colorless and transparent, with a similar density to that of natural vitreous [72].…”

Section: Ophthalmic Hydrogelsmentioning

confidence: 99%

Structural Strategies of Supramolecular Hydrogels and Their Applications

Sánchez-Fernández¹

2023

Preprint

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Supramolecular structures are of great interest due to their applicability in various scientific and industrial fields. These fields of scientific action include promising applications i biomedical areas, in sensing, and in conductive and electrical phases. The sensible definition of supramolecular molecules is being set by investigators, who, because of the different sensitivities of their methods and observational timescales, may have different views as to what constitute these supramolecular structures. Besides, diverse polymers can be found to offer unique avenues for multifunctional systems with properties in medicine industrial applications. Aspects of this review provide different conceptual strategies to address molecular design, properties, and potential applications of self-assembly materials and the use of metal coordination as a feasible and useful strategy for constructing complex supramolecular structures. In this order of appreciations and ideas order, it is that this review report involves classic topics such as hydrogels that range from their relationship with drug delivery systems, to metallo-supramolecular materials, through applications in ophthalmic systems, in applications that require adhesiveness and electrically conductive hydrogels. This review also addresses systems that are largely based on hydrogel chemistry and the enormous opportunities to design very specific structures for applications that demand enormous specificity.

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Supramolecular host-guest hyaluronic acid hydrogels enhance corneal wound healing through dynamic spatiotemporal effects

Cited by 32 publications

References 44 publications

Dual-crosslinked regenerative hydrogel for sutureless long-term repair of corneal defect

Dual-crosslinked regenerative hydrogel for sutureless long-term repair of corneal defect

Cell‐instructive biomaterials in tissue engineering and regenerative medicine

Structural Strategies of Supramolecular Hydrogels and Their Applications

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