Supramolecular Electrochemical Sensor for Dopamine Detection Based on Self-Assembled Mixed Surfactants on Gold Nanoparticles Deposited Graphene Oxide

Abstract

A new supramolecular electrochemical sensor for highly sensitive detection of dopamine (DA) was fabricated based on supramolecular assemblies of mixed two surfactants, tetra-butylammonium bromide (TBABr) and sodium dodecyl sulphate (SDS), on the electrodeposition of gold nanoparticles on graphene oxide modified on glassy carbon electrode (AuNPs/GO/GCE). Self-assembled mixed surfactants (TBABr/SDS) were added into the solution to increase the sensitivity for the detection of DA. All electrodes were characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The supramolecular electrochemical sensor (TBABr/SDS⋅⋅⋅AuNPs/GO/GCE) showed excellent electrocatalytic activity toward the oxidation of DA. Under the optimum conditions, the concentration of DA was obtained in the range from 0.02 µM to 1.00 µM, with a detection limit of 0.01 µM (3s/b). The results displayed that TBABr/SDS⋅⋅⋅AuNPs/GO/GCE exhibited excellent performance, good sensitivity, and reproducibility. In addition, the proposed supramolecular electrochemical sensor was successfully applied to determine DA in human serum samples with satisfactory recoveries (97.26% to 104.21%).

Ultrasensitive Electrochemical Sensor for Luteolin Based on Zirconium Metal-Organic Framework UiO-66/Reduced Graphene Oxide Composite Modified Glass Carbon Electrode

“…In order to verify the application of UiO-66/ErGO/GCE for real samples, extracts of chrysanthemums and hawthorn were determined, which contained certain amounts of LU. In order to make the results more accurate, the standard addition method was used by adding three different concentrations of LU to samples under the optimal detection conditions [ 41 ]. As Table 2 showed, the recovery rates of test samples were 99.85–101.17%, and the RSD values were between 0.77 and 6.86%, which demonstrated the good performance and reliable results of UiO-66/ErGO/GCE for testing real samples.…”

Evolution of Supramolecular Systems Towards Next-Generation Biosensors

“…In another example, Uppachai et al applied supramolecular chemistry with surfactant assemblies to improve electrochemical sensor sensitivity for dopamine detection. The supramolecular assemblies formed by tetra-butylammonium bromide and sodium dodecyl sulphate enhance the electron transfer of dopamine due to hydrophobic interaction and electrostatic attraction between dopamine and gold nanoparticles on the modified glassy carbon electrode ( Uppachai et al, 2020 ). Shen et al reported a supramolecular aptamer self-assembled by the thiolated aptamer probe and a biotin-labeled analog in the presence of cocaine.…”

Construction of a Highly Selective and Sensitive Dopamine Enzyme‐free Biosensor Based on Carbon Nanomaterials

“…Therefore, DA detection is important in the diagnosis and treatment of central nervous system diseases and biochemistry. Currently, many methods are undertaken for DA detection, including spectroscopy, chromatography and electrochemistry [3]. The electrochemical method is easy to operate, fast, highly sensitive, and inexpensive.…”