Supramolecular design of coordination bonding architecture on zein nanoparticles for pH-responsive anticancer drug delivery

Liang, Hongshan; Zhou, Bin; Li, Jing; Xu, Wei; Liu, Shilin; Li, Yan; Chen, Yijie; Li, Bin

doi:10.1016/j.colsurfb.2015.09.037

Cited by 59 publications

(32 citation statements)

References 58 publications

(78 reference statements)

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“…At a zein to TA ratio of 4:1, the zeta potential increased from 35.5 to 47.8 mV, leading to higher colloidal stability. In contrast, when the concentration of TA was increased, the zeta potential decreased, likely due to the acidic nature of the galloyl groups in TA (Liang et al ., c).…”

Section: Resultsmentioning

confidence: 99%

“…Tannic acid (TA), a natural plant polyphenol, has exhibited lots of biological activities such as antimutagenic, anticarcinogenic, antimicrobial, antioxidant and antibacterial activities (Daglia, ; Zhang et al ., ). From a structural point of view, the possession of abundant terminal hydroxyl groups facilitates interactions of TA with a variety of materials such as polysaccharides (Liang et al ., ), proteins (Taylor et al ., ; Liang, Zhou, Li et al ., ) and synthetic polymers (Fei Liu et al ., ; Shin et al ., ) via multiple mechanisms (Costa et al ., ; Rahim et al ., ; Liang, Zhou, Li et al ., ).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Pickering emulsions stabilised by zein/tannic acid colloidal particles with low concentration

Zhou

Gao

et al. 2019

Int J of Food Sci Tech

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Pickering emulsions are widely used as a carrier and protective systems in many fields for encapsulationspecific bioactive substances. In this current study, we fabricated an antioxidant Pickering emulsions stabilised by zein/tannic acid nanoparticle. Results showed that coalescence and creaming stability of the emulsion highly depended on the concentration of the particles and the zein to TA ratio in the formulation. A 0.3% concentration of zein and a 1:1 zein to TA ratio was found to exhibit optimal stabilising capability. Given the intrinsic antioxidant activity of tannic acid, which forms a protective shell, the oxidative deterioration of the oil in the emulsion could be significantly prevented. These data suggest that the ZTNPs established in the present study are a promising emulsifier in the Pickering emulsion. It is promising as a green, safe, high-performance particle stabiliser and a novel food ingredient for use in interface-oriented food systems.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant Pickering emulsions stabilised by zein/tannic acid colloidal particles with low concentration

Zhou

Gao

et al. 2019

Int J of Food Sci Tech

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“…33 A previous study confirmed that DOX could be loaded in zein NPs. 7 Furthermore, the positively charged DOX could be absorbed onto the surface of negatively charged zein/CMCS NPs by electrostatic interaction. 7,22,43,44 The particle size of DOX-loaded zein 1 / CMCS 1 NPs was 135.2 nm with ideal PDI, and the encapsulation efficiency was 91.0% (Table S5).…”

Section: Preparation and Characterization Of Dox-loaded Npsmentioning

confidence: 99%

“…[1][2][3][4] The release of guest molecules can be tailored using their responsiveness to external stimuli such as pH, [5][6][7][8][9] temperature 10 and light. [11][12][13] Among these stimuli-responsive systems, the pH-sensitive system is of vast interest because of the acidic microenvironment in solid tumors, which is very different compared with the normal tissues.…”

Section: Introductionmentioning

confidence: 99%

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Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding

Liang¹,

Zhou²,

He³

et al. 2017

IJN

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In this study, a novel coordination bonding system based on metal–tannic acid (TA) architecture on zein/carboxymethyl chitosan (CMCS) nanoparticles (NPs) was investigated for the pH-responsive drug delivery. CMCS has been reported to coat on zein NPs as delivery vehicles for drugs or nutrients in previous studies. The cleavage of either the “metal–TA” or “NH 2 –metal” coordination bonds resulted in significant release of guest molecules with high stimulus sensitivity, especially in mild acidic conditions. The prepared metal–TA-coated zein/CMCS NPs (zein/CMCS-TA/metal NPs) could maintain particle size in cell culture medium at 37°C, demonstrating good stability compared with zein/CMCS NPs. In vitro release behavior of doxorubicin hydrochloride (DOX)-loaded metal–TA film-coated zein/CMCS NPs (DOX-zein/CMCS-TA/metal NPs) showed fine pH responsiveness tailored by the ratio of zein to CMCS as well as the metal species and feeding concentrations. The blank zein/CMCS-TA/metal NPs (NPs-TA/metal) were of low cytotoxicity, while a high cytotoxic activity of DOX-zein/CMCS-TA/metal NPs (DOX-NPs-TA/metal) against HepG2 cells was demonstrated by in vitro cell assay. Confocal laser scanning microscopy (CLSM) and flow cytometry were combined to study the uptake efficiency of DOX-NPs or DOX-NPs-TA/metal. This system showed significant potential as a highly versatile and potent platform for drug delivery.

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Natural Polyphenol–Vanadium Oxide Nanozymes for Synergistic Chemodynamic/Photothermal Therapy

Chen

Huang

Liang

et al. 2020

Chemistry A European J

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The selection of suitable nanozymes with easy synthesis, tumor specificity,m ultifunction,a nd high therapeutics is meaningful for tumor therapy.H erein, af acile onestep assembly approach was employed to successfully prepare an ovel kind of naturalp olyphenol tannic acid (TA) hybrid with mixed valence vanadium oxide nanosheets (TA@VO x NSs). In this system, VO x is assembled with TA through metal-phenolic coordination interaction to both introduce superior peroxidase-like activity and high near infrared (NIR) absorption owing to partial reduction of vanadium from V 5 + to V 4 + .T he presence of mixed valencev anadium oxide in TA@VO x NSs is proved to be the key for the catalytic reaction of hydrogen peroxide (H 2 O 2)t oCOH, and the corre-spondingc atalytic mechanism of H 2 O 2 by TA@VO x NSsi s proposed. Benefitting from such peroxidase-like activity of TA@VO x NSs, the overproduced H 2 O 2 of the tumor microenvironmenta llows the realization of tumor-specific chemodynamic therapy (CDT). As av alid supplementt oC DT,t he NIR absorption enables TA@VO x NSs to have NIR light-mediated conversion ability for photothermal therapy(PTT) of cancers. Furthermore, in vitro and in vivo experimentsc onfirmed that TA@VO x NSs can effectively inhibit the growth of tumors by synergistic CDT/PTT.T hese resultso ffer ap romising way to develop novel vanadium oxide-based nanozymes for enhanced synergistic tumor-specific treatment.

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Supramolecular design of coordination bonding architecture on zein nanoparticles for pH-responsive anticancer drug delivery

Cited by 59 publications

References 58 publications

Antioxidant Pickering emulsions stabilised by zein/tannic acid colloidal particles with low concentration

Antioxidant Pickering emulsions stabilised by zein/tannic acid colloidal particles with low concentration

Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding

Natural Polyphenol–Vanadium Oxide Nanozymes for Synergistic Chemodynamic/Photothermal Therapy

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Supramolecular design of coordination bonding architecture on zein nanoparticles for pH-responsive anticancer drug delivery

Cited by 59 publications

References 58 publications

Antioxidant Pickering emulsions stabilised by zein/tannic acid colloidal particles with low concentration

Antioxidant Pickering emulsions stabilised by zein/tannic acid colloidal particles with low concentration

Tailoring stimuli-responsive delivery system driven by metal&ndash;ligand coordination bonding

Natural Polyphenol–Vanadium Oxide Nanozymes for Synergistic Chemodynamic/Photothermal Therapy

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Product

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Tailoring stimuli-responsive delivery system driven by metal–ligand coordination bonding