Supramolecular cyclodextrin pseudorotaxane hydrogels: A candidate for sustained release?

Chee, Pei Lin; Prasad, Ankshita; Fang, Xiaotian; Owh, Cally; Yeo, Valerie Jing Jing; Loh, Xian Jun

doi:10.1016/j.msec.2014.02.026

Cited by 42 publications

(35 citation statements)

References 33 publications

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“…Supramolecular assemblies based on macrocycles such as cyclodextrins 34,36,45 and cucurbiturils [46][47][48][49] have been reported previously. Such a macroinitiator could be used for synthesis of a wide variety of PGS-based materials via ATRP with most ATRPcompatible monomers such as (meth)acrylates and (meth) acrylamides.…”

Section: Discussionmentioning

confidence: 86%

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A thixotropic polyglycerol sebacate-based supramolecular hydrogel showing UCST behavior

Owh

Loh

2015

RSC Adv.

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Polyglycerol sebacate (PGS) is a relatively new biodegradable and elastomeric material that exhibits superior biocompatibility, a modulus that is comparable to human soft tissue, and linear biodegradation. However, the high hydrophobicity, low water uptake percentage and extreme synthesis conditions of PGS pose as a hindrance to its use in cellular biology, biomedical and other applications. We were able to modify PGS using atom transfer radical polymerization (ATRP) by synthesizing a PGS macroinitiator, allowing us to improve PGS's properties or introduce new properties to PGS. This macroinitiator would enable the building of a robust platform of PGS-based copolymers with monomers in the methacrylates, styrenes and methacrylamide families. We demonstrated the feasibility of this macroinitiator by using PEGMEMA as the monomer to synthesize PGS-PEGMEMA and created a PGS-PEGMEMA/aCD supramolecular hydrogel system. This hydrogel exhibited a tunable, low UCST of less than 90 C, low minimum gelation concentration of 5.2%, rapid gelation and rapid self-healing ability with relatively high modulus ($100 kPa) that is comparable to that of human soft tissue. This hydrogel system is injectable yet strong enough to provide supportfeatures, making it a very suitable candidate as a vehicle for injectable sustained-release drug delivery, cell delivery, tissue engineering scaffold as well as for cosmetics and skincare applications.

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Section: Discussionmentioning

confidence: 86%

“…33,34 Supramolecular constructs have been reported to form hydrogels in several reviews. 33,34 Supramolecular constructs have been reported to form hydrogels in several reviews.…”

Section: Introductionmentioning

confidence: 99%

A thixotropic polyglycerol sebacate-based supramolecular hydrogel showing UCST behavior

Owh

Loh

2015

RSC Adv.

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“…[10][11][12][13][14] Additionally, supramolecular architectures of polyrotaxanes and polypseudorotaxanes are increasingly diverse and much of scienti¯c literature has been working on narrowing the gap between polymeric structures and functionality for drug delivery, conducting materials, arti¯cial molecular machines, gene delivery, supra-amphiphiles, and other functional supramolecular systems. There is ample potential to employ polyrotaxanes or polypseudorotaxanes in antibacterial or antifungal therapy.…”

Section: Responsive Antibacterial Materialsmentioning

confidence: 99%

Latest Advances in Antibacterial Materials

Loh

2017

J. Mol. Eng. Mater.

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This paper will update readers on the latest work in the area of antibacterial polymeric systems. There is extensive literature on existing systems. This complexity con¯nes us to the latest antibacterial materials which possess (1) responsive antibacterial activity on their own; (2) antibio¯lm formation and (3) formation of antibacterial polymeric¯lms. The objective of this review is to provide an overview of the antibacterial synthetic polymer¯eld. In this paper, I will analyze the early promise of this technology as well as highlight potential challenges that adopters could face. The primary focus will be the application of materials to the medical industry and to show how these materials can be tailored to create responsive, customized bactericidal materials.

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“…7 In addition, chemical modi¯cation of CDs or the tailoring of CDs' structure is widely used for di®erent applications such as food preservation, drug and gene delivery. [8][9][10][11][12] Although chemical modi¯cation of CDs is common, there has been little focus on the antimicrobial application of chemically modi¯ed-CDs.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrins: A Weapon in the Fight Against Antimicrobial Resistance

Wong

Dolzhenko

Lee

et al. 2017

J. Mol. Eng. Mater.

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Antimicrobial resistance poses one of the most serious global challenges of our age. Cyclodextrins (CDs) are widely utilized excipients in formulations because of their solubilizing properties, low toxicity, and low in°ammatory response. This review summarizes recent investigations of antimicrobial agents involving CDs and CD-based antimicrobial materials. CDs have been employed for antimicrobial applications either through formation of inclusion complexes or by chemical modi¯cation of their hydroxyl groups to tailor pharmaceutically active compounds. Applications of these CD inclusion complexes include drug delivery, antimicrobial coatings on materials (e.g., biomedical devices and implants) and antimicrobial dressings that help to prevent wound infections. There are relatively limited studies of chemically modi¯ed CDs with antimicrobial activity. The mechanism of action of antimicrobial CD inclusion complexes and derivatives needs further elucidation, but activity of CDs and their derivatives is often associated with their interaction with bacterial cell membranes.

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Supramolecular cyclodextrin pseudorotaxane hydrogels: A candidate for sustained release?

Cited by 42 publications

References 33 publications

A thixotropic polyglycerol sebacate-based supramolecular hydrogel showing UCST behavior

A thixotropic polyglycerol sebacate-based supramolecular hydrogel showing UCST behavior

Latest Advances in Antibacterial Materials

Cyclodextrins: A Weapon in the Fight Against Antimicrobial Resistance

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