Supramolecular Control in Nanostructured Film Architectures for Detecting Breast Cancer

Soares, Juliana Coatrini; Shimizu, Flávio M.; Soares, Andrey Coatrini; Caseli, Luciano; Ferreira, Josiel; Oliveira, Osvaldo N.

doi:10.1021/acsami.5b03761

Cited by 40 publications

(48 citation statements)

References 33 publications

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“…The whole spectra of normalized magnitude impedance data for all the samples were analyzed with the multidimensional projection technique Interactive Document Map (IDMAP) using the PEx-Sensors software [70][71][72]. In IDMAP data dimensions are Fig.…”

Section: Impedance Spectroscopy Measurements Of Znco 2 O 4 Yolk-shellmentioning

confidence: 99%

Yolk-shelled ZnCo2O4 microspheres: Surface properties and gas sensing application

Joshi

Silva

Jadhav

et al. 2018

Sensors and Actuators B: Chemical

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203

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The need to improve the sensitivity, selectivity and stability of ozone gas sensors capable of monitoring the environment to prevent hazard to humans has sparked research on binary metal oxides. Here we report on a novel ozone gas sensor made with ca. 0.5 m yolk-shelled ZnCo 2 O 4 microstructures synthesized via an eco-friendly, co-precipitation method and subsequent annealing. With these ZnCo 2 O 4 microspheres, ozone concentrations down to 80 parts per billion (ppb) could be detected with a.c. and d.c. electrical measurements. The sensor worked within a wide range of ozone concentrations, from 80 to 890 ppb, being also selective to ozone compared to CO, NH 3 and NO 2. The high performance could be attributed to the large surface area to volume ratio inherent in yolk-shell structures. Indeed, ozone molecules adsorbed on the ZnCo 2 O 4 surface create a layer of holes that affect the conductivity, as in a p-type semiconductor. Since this mechanism of detection is generic, ZnCo 2 O 4 microspheres can be further used in other environment monitoring devices.

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Section: Impedance Spectroscopy Measurements Of Znco 2 O 4 Yolk-shellmentioning

confidence: 99%

Yolk-shelled ZnCo2O4 microspheres: Surface properties and gas sensing application

Joshi

Silva

Jadhav

et al. 2018

Sensors and Actuators B: Chemical

Self Cite

203

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“…Human epidermal growth factor receptor 2 (HER2 or ERBB2) is a significant biomarker found in breast cancer and was detected by Electrochemical impedance spectroscopy using a self-assembled monolayer of cysteine [138]. Lipoproteins [139], serum oncomarker CA125 [140], and tissue polypeptide antigen [141] were also sensitively detected via impedance, and impedimetric derived immunoassays in ovarian cancer patients for early diagnostics.…”

Section: Nanomaterials Biosensors In Cancer Cellmentioning

confidence: 99%

Recent Advances and Applications of Biosensors in Novel Technology

Rajpoot¹

2017

Biosens J

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In recent time, several novel biosensors such as enzyme based, immunosensors, tissue-based, DNA biosensors, piezoelectric, and thermal biosensors have been explored with high sensitivity by many research groups. These biosensors exhibit many essential benefits, including operational simplicity, remarkable sensitivity, low-cost instrumentation, the potential of automation, inherent miniaturization. They have offered elegant paths for the detection of even trace amounts of analytical agents of biological significance existing from macromolecules (e.g., disease biomarkers and antigens) and small molecules (e.g., natural toxins and haptens) to cells, viruses, and bacteria. Many electrochemical techniques viz., amperometry and voltammetry, photoelectrochemistry, electrochemiluminescence, impedance, piezoelectricity, potentiometry, alternating current electrohydrodynamics, and field-effect transistor have been utilized in the development of immunoassays to attain high sensitivity for electrochemical signal transduction. Recent developments in biological methods and instrumentation after using fluorescence tag to various nanocarriers such as nanoparticles, nanowires, nanotubes, etc. have improved the sensitivity of biosensors. Utilization of nucleotides/aptamers, affibodies, molecule imprinted polymers, and peptide arrays offer great tools to prepare advanced biosensors. Merging of nanotechnology with biosensor systems enhanced the diagnostic capability. This review gives an outline of the advances in biosensors technology relating biomedical sciences.

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“…Desde então, uma grande variedade de métodos para detecção de marcadores biológicos envolvendo processos cinéticos como adsorção-dessorção, interações proteína-ligante, interações antígeno-anticorpo, receptor ligante e proteína-DNA/RNA, vem sendo desenvolvidos. [46][47][48][49][50][51][52][53][54][55] As principais vantagens destes sensores plasmônicos se concentram em elevadas sensibilidades e medidas em tempo real sem a necessidade de marcação de biomoléculas.…”

Section: Aplicação De Nanopartículas Plasmônicas Em Sensores Biológicosunclassified

Ressonância de plasmon de superfície localizado e aplicação em biossensores e células solares

Santos¹,

Santos²,

Thesing³

et al. 2016

Quim. Nova

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LOCALIZED SURFACE PLASMON RESSONANCE APPLIED TO BIOSENSORS AND SOLAR CELLS. Within the last decades, the research on nanoparticles presenting localized surface plasmon resonance has increased constantly. In these materials, the interaction between electrons and incident light results in charge separation, enhancement of the electromagnetic field on the nanoparticles surface and in unique optical properties. Although many metals such as gold, silver, copper and aluminum present localized surface plasmon resonance within the visible range, gold and silver are the most commonly studied metals, due to the chemical inertia of gold and intense plasmon resonance from silver. In this review, we provide a description of the origin of localized surface plasmon resonance through the works developed by Mie, Maxwell and Maxwell-Garnett and a description of many examples of application of plasmonic nanoparticles on biosensors and solar cells, detailing the contribution of these plasmonic nanoparticles on the performance of these devices.Keywords: LSPR; Localized Surface Plasmon Resonance; biosensor; solar cell. INTRODUÇÃONos últimos 20 anos o interesse por nanopartículas metálicas (NPs-M) tem aumentado constantemente devido a sua ampla variedade de aplicações.1-8 Vários grupos de pesquisa têm estudado desde nanopartículas isoladas de cerca de 1 nm até nanopartículas de centenas de nanômetros, assim como seus aglomerados, buscando entender seu comportamento óptico e catalítico. Adicionalmente, a literatura descreve a constante busca por metodologias de síntese cada vez mais simples, de baixo custo e com alta reprodutibilidade. O comportamento óptico de nanopartículas metálicas tem fascinado a humanidade há vários séculos através de obras de arte, mesmo antes que a palavra nanotecnologia fosse utilizada.9 Um dos exemplos mais conhecidos é a Taça de Lycurgus (século 4 d.C), que tem em sua composição nanopartículas de ouro (NPAu).10 No entanto, foi somente em 1857 que as NPs-M receberam maior atenção devido aos estudos de Michael Faraday sobre o efeito da interação da luz em uma solução coloidal de NPAu obtida através da redução do cloreto de ouro pelo fósforo.11,12 Deste então, o interesse nestas NPs tem aumentado e novas metodologias de síntese e caracterização têm sido desenvolvidas, possibilitando grande controle de tamanho e formato.13-15 A pesquisa nesta área foi enriquecida pela compreensão do efeito da ressonância de plasmon de superfície localizado (LSPR), que explica o comportamento óptico destes materiais. Mie foi o primeiro a elucidar a origem das cores nestas estruturas e sua teoria foi posteriormente complementada com os modelos de Maxwell-Garnett que explicavam a interação de NPs-M com o meio. Estes estudos proporcionaram uma ampla visão quanto as possíveis aplicações das NPs-M, sendo atualmente empregada no desenvolvimento de novos materiais como células solares, biossensores e catalisadores. Nesta revisão, serão abordados os embasamentos teóricos envolvidos no efeito LSPR de NPs-M, destacando a aplicação destas n...

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Supramolecular Control in Nanostructured Film Architectures for Detecting Breast Cancer

Cited by 40 publications

References 33 publications

Yolk-shelled ZnCo2O4 microspheres: Surface properties and gas sensing application

Yolk-shelled ZnCo2O4 microspheres: Surface properties and gas sensing application

Recent Advances and Applications of Biosensors in Novel Technology

Ressonância de plasmon de superfície localizado e aplicação em biossensores e células solares

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