Structures of 7-[2-(morpholin-4-yl)ethyl]-3-(2-ethoxyethyl)-3,7-diazabicyclo[3.3.1]nonane and its inclusion complexes with α-, β-, and γ-cyclodextrins have been studied by 1 H, 13 C, COSY, and HMQC NMR spectroscopy. The complexes are formed via entering of one morpholine fragment of the substrate into the inner sphere of a receptor molecule..1]nonane, α-, β-, and γ-cyclodextrin, inclusion complex, NMR spectroscopy NMR spectroscopy has been recognized among the most informative methods to investigate structure and intermolecular interactions in inclusion complexes [1]. Therefore, we have applied this method to study new drug formulations of pharmaceutically active 7-[2-(morpholin-4-yl)ethyl]-3-(2-ethoxyethyl)-3,7-diazabicyclo[3.3.1]nonane I with cyclodextrins.Compound I possesses a wide range of biological activity due to the presence of two piperidine rings in the structure; in particular, it displays a local anesthetic effect [2].Cyclodextrins are accessible compounds produced from renewable source (starch), the most widespread types of them being α-, β-, and γ-cyclodextrins containing 6, 7, and 8 glucopyranose units, respectively. Cyclodextrins are capable of hydrophobic binding of a guest molecule in their cavity in aqueous medium.