Supramolecular cobalt(II)-pyridine-2,5-dicarboxylate complexes with isonicotinamide, 2-amino-3-methylpyridine and 2-amino-6-methylpyridine: Syntheses, crystal structures, spectroscopic, thermal and antimicrobial activity studies

Çolak, Alper Tolga; Çolak, Ferdağ; Yeşılel, Okan Zafer; Akduman, Demet; Yılmaz, Filiz; Tümer, Mehmet

doi:10.1016/j.ica.2010.03.007

Cited by 42 publications

(15 citation statements)

References 40 publications

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“…This increased lipophilicity enhances the penetration of the complexes into lipid membrane and thus blocks the metal binding sites on enzymes of microorganisms. These metal complexes also disturb the respiration process of the cell and thus block the synthesis of proteins, which restricts further growth of the organism …”

Section: Resultsmentioning

confidence: 99%

Azo dye with nitrogen donor sets of atoms and its metal complexes: Synthesis, characterization, DFT, biological, anticancer and Molecular docking studies

Mahmoud

Sayed

2018

Applied Organom Chemis

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An azo derivative was synthesized by coupling diazotized 2,6-diaminopyridine with p-dimethyl amino benzaldehyde and this new ligand formed a series of metal complexes with Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) salts. These complexes were characterized on the basis of elemental analyses, molar conductance, infrared spectroscopy, UV-Vis, 1 H NMR, mass spectrometry, electronic spectra, magnetic susceptibility and ESR spectral studies, conductivity measurements, thermogravimetric analyses (TG-DTG). The molecular and electronic structure of the azo ligand was optimized theoretically and the quantum chemical parameters were calculated. The ligand and its metal complexes were subjected to X-ray powder diffraction study. The thermal stability of the ligand and its metal complexes was examined by thermogravimetry. The ligand and its complexes were tested for their in vitro antimicrobial activity, some of the complexes showed good antimicrobial activities against some selected bacterial and fungal strains. Anticancer activity of the ligand and its metal complexes are evaluated against human cancer (MCF-7 cells viability). Molecular docking was used to predict the binding between azo ligand and the receptors of nucleoside diphosphate kinase of Staphylococcus aureus (3Q8U) and (3HB5) which is breast cancer mutant oxidoreductase. The docking study provided useful structural information for inhibition studies.

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Section: Resultsmentioning

confidence: 99%

Azo dye with nitrogen donor sets of atoms and its metal complexes: Synthesis, characterization, DFT, biological, anticancer and Molecular docking studies

Mahmoud

Sayed

2018

Applied Organom Chemis

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“…It is inferred that the first step of mass loss is attributed to the loss of coordinated water (118 ˚C -155 ˚C) [11] [20]. The following three stages commenced with the loss of isonicotinamide (170˚C -260˚C; 270˚C -330˚C, 330˚C -380˚C) and the last step was the counter-ion output and the CoO 4 reduction to CoO (830˚C -930˚C) [21] [22].…”

Section: Thermoanalytical Techniquesmentioning

confidence: 99%

Synthesis and Characterization of a New Compound of Cobalt II with Isonicotinamide and Evaluation of the Bactericidal Potential

Galvão¹,

Moraes²,

Sousa³

et al. 2019

OJIC

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In this work, the isonicotinamide was coordinated to the Cobalt ion in oxidation state +2. The relevance of this work is the investigation of the in vitro bactericidal potential of the synthesized complex when tested in Gram-positive and negative bacteria strains. This study is motivated by the need to obtain new materials that have antibiotic properties and that, in the future, may become an effective drug against resistant bacteria. A new coordination compound of Cobalt and isonicotinamide, [Co(H 2 O)(isn) 3 ](BF 4) 2 , was synthesized and described. The compound was characterized by thermoanalytical techniques TG-DTG and TG-DSC, where it was possible to propose the mechanism of thermal decomposition. Through the spectroscopy in the region of the medium infrared (FTIR), it is possible to infer the site of connection between isonicotinamide and metal. The bactericidal activity of [Co(H 2 O)(isn) 3 ](BF 4) 2 , CoCl 2 and free Isonicotinamide were tested for the bacteria Streptococcus mutans (Gram+) and Escherichia coli (Gram−) and the synthesized compound showed to be sensitive for both bacteria.

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“…11,19,29,30 On the other hand, cobalt compounds have attracted extensive interest in recent years owing to their intriguing structures and biomedicinal propertires. 18,[31][32][33][34] On the basis of the aforementioned points, we have attempted to synthesize new cobalt supramolecular complexes with mixed ligands containing H 4 btec and 2,2'-bipy. In this paper, we report the synthesis, structure, and thermal properties of two 3D cobalt(II) compounds [Co(2,2'-bipy)(…”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis, Crystal Structures and Thermal Properties of Two Three-Dimensional Cobalt(II) Complexes

Tao¹,

Li²,

Cheng³

et al. 2012

Bulletin of the Korean Chemical Society

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Two cobalt(II) compounds [Co(2,2'-bipy)(H 2 O) 2 (SO 4 )] n (1) and [Co 2 (2,2'-bipy) 2 (btec)(H 2 O) 6 ]·2H 2 O (2) (2,2'-bipy = 2,2'-bipyridine, H 4 btec = 1,2,4,5-benzenetetracarboxylic acid), have been simultaneously synthesized by a one-pot slow solvent evaporation reaction. Their structures were determined by single-crystal X-ray diffraction and further characterized by X-ray powder diffraction (XRPD), IR, elemental and thermogravimetric analysis (TGA). The structural analysis reveals that compound 1 exhibits an infinite 1D chain structure with the octahedral Co(II) centers bridging by the tetrahedral µ 2 -SO 4 2− ligands, while compound 2 possesses a dinuclear Co 2 (2,2'-bipy) 2 (btec)(H 2 O) 6 unit and the two adjacent octahedral Co(II) ions are linked by the bismonodentately coordinated btec ligand. Additionally, compound 2 exhibits blue fluorescent emission in the solid state at room temperature.

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Supramolecular cobalt(II)-pyridine-2,5-dicarboxylate complexes with isonicotinamide, 2-amino-3-methylpyridine and 2-amino-6-methylpyridine: Syntheses, crystal structures, spectroscopic, thermal and antimicrobial activity studies

Cited by 42 publications

References 40 publications

Azo dye with nitrogen donor sets of atoms and its metal complexes: Synthesis, characterization, DFT, biological, anticancer and Molecular docking studies

Azo dye with nitrogen donor sets of atoms and its metal complexes: Synthesis, characterization, DFT, biological, anticancer and Molecular docking studies

Synthesis and Characterization of a New Compound of Cobalt II with Isonicotinamide and Evaluation of the Bactericidal Potential

One-Pot Synthesis, Crystal Structures and Thermal Properties of Two Three-Dimensional Cobalt(II) Complexes

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