2015
DOI: 10.1039/c5cc04982b
|View full text |Cite
|
Sign up to set email alerts
|

Supramolecular chirality in self-assembled peptide amphiphile nanostructures

Abstract: Induced supramolecular chirality was investigated in the self-assembled peptide amphiphile (PA) nanosystems. Having shown that peptide chirality can be transferred to the covalently-attached achiral pyrene moiety upon PA self-assembly, the chiral information is transferred to molecular pyrene via weak noncovalent interactions. In the first design of a supramolecular chiral system, the chromophore was covalently attached to a peptide sequence (VVAGH) via an e-aminohexanoic acid spacer. Covalent attachment yield… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
35
0
1

Year Published

2016
2016
2022
2022

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 36 publications
(36 citation statements)
references
References 28 publications
0
35
0
1
Order By: Relevance
“…24 Valine and alanine residues in particular are b-sheet promoting amino acids, and the VVAG motif in the lauryl-VVAGERGD peptide is capable of mediating its self-assembly through b-sheet formation. 47 Minimal changes were observed between Na + and Cl À -mediated assembly; however, the Cl Àmediated assembly (the PA3 nanober) also had more b-sheet formation compared to the Na + -mediated (the PA1 nanober) Fig. 8 Snapshots of the gradually heated PA1 nanofiber from 300 K to 358 K (simulation-2).…”
Section: Discussionmentioning
confidence: 99%
“…24 Valine and alanine residues in particular are b-sheet promoting amino acids, and the VVAG motif in the lauryl-VVAGERGD peptide is capable of mediating its self-assembly through b-sheet formation. 47 Minimal changes were observed between Na + and Cl À -mediated assembly; however, the Cl Àmediated assembly (the PA3 nanober) also had more b-sheet formation compared to the Na + -mediated (the PA1 nanober) Fig. 8 Snapshots of the gradually heated PA1 nanofiber from 300 K to 358 K (simulation-2).…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, it is well known that pyrene moieties are able to self‐aggregate, thus establishing weak intermolecular interactions (i.e., π–π interactions) to form ordered mesophases or even induce supramolecular chirality . Moreover, pyrene optical properties (absorption and luminescence) are highly sensitive to the medium polarity and to the molecular packing processes and supramolecular associations in the microenvironment that surround the probe, which makes it a good sensor for self‐assembly processes and micelle/vesicle formation …”
Section: Introductionmentioning
confidence: 99%
“…[14] On the other hand, it is well knownt hat pyrene moieties are able to self-aggregate, thus establishing weaki ntermolecular interactions (i.e., p-p interactions) to form ordered mesophases [15] or even induce supramolecular chirality. [16] Moreover, pyrene optical properties (absorption andl uminescence) are highly sensitive to the mediump olarity andt ot he molecular packing processes and supramolecular associations in the microenvironment that surround the probe, which makes it a good sensorf or self-assembly processes and micelle/vesicle formation. [17,18] This study is primarily aimed at the control and tuning of the supramolecular self-assembly process between catecholcontaining amphiphilic molecules with two differentm oieties able to establish intermolecular interactions.…”
Section: Introductionmentioning
confidence: 99%
“…[3] Among other sophisticated and efficient molecular building blocks, the use of synthetic peptides able to favor p-p interac-tions betweenp hoto-and electroactivea romatic systemsh as been recognized as an effective strategy to achieve supramolecular polymeric materialsw ith applicationsin organic electronics. Recent investigations have been focused in this direction, for which amino acid mutation, [6] enhancement of the intermolecular p-p interactions betweena romatic units, [7] or solvent-controlled assembly [8] have been used to modify the properties of the functional supramolecular materials. [5] Furthermore, their final function and applications are dramatically affected by these parameters.…”
Section: Introductionmentioning
confidence: 99%