Supramolecular block copolymers for gene delivery: enhancement of transfection efficiency by charge regulation

Yasen, Wumaier; Dong, Ruijiao; Zhou, Linzhu; Huang, Yu; Guo, Dongbo; Chen, Dong; Li, Chuanlong; Aini, Aliya; Zhu, Xinyuan

doi:10.1039/c7cc07652e

Cited by 11 publications

(4 citation statements)

References 32 publications

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“…Therefore, VE might be located in the hydrophobic void of β-CD or β-CD amino derivatives where VE experiences an environment transition from polarity to nonpolarity . 2-D ROESY is a powerful technique to provide the proton–proton correlation information between different compounds based on the nuclear Overhauser effect (NOE). − For β-CD/VE (Figure a), the ROESY spectrum displayed the NOE cross-peaks between the internal H5 protons from β-CD and H a protons from VE (peaks A), the cross-peaks between the external OH2 protons and OH3 protons from β-CD and H a protons from VE (peaks B). This result indicates that phenol moiety of VE was self-included into the cavity of β-CD and that entered spontaneously from the secondary OH face (marked by the light pink rectangle).…”

Section: Resultsmentioning

confidence: 99%

Construction of Crowning β-cyclodextrin with Temperature Response and Efficient Properties of Host–Guest Inclusion

et al. 2018

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Promoting a drug inclusion proportion in hydrophobic cavity of β-cyclodextrin using simple methods is a highly ambitious task. Herein, we report the crowning β-cyclodextrins formed by intramolecular hydrogen bonding interaction, which has greatly prolonged the cavity depth of β-cyclodextrin, and therefore further efficiently improved the inclusion proportion to complex drug molecule (vitamin E). Furthermore, the self-assembly behaviors, controllable release, and antioxidant properties of vitamin E embedded into the cavity of crowning β-cyclodextrins was investigated, and host-guest inclusions exhibited temperature-responsive controlled release, excellent antioxidant activity, and photostability.

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Section: Resultsmentioning

confidence: 99%

Construction of Crowning β-cyclodextrin with Temperature Response and Efficient Properties of Host–Guest Inclusion

et al. 2018

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“…Benefiting from the dynamic nature of non-covalent interaction, supramolecularly engineered polymers usually respond to environmental change in a fast and precise way, which makes them good platforms for drug-delivery carriers. To date, various designs of supramolecular polymeric delivery carriers have been reported to achieve the successful delivery of chemo-drugs [ 55–58 ], therapeutic enzymes [ 59–61 ] and genetic materials [ 62–65 ].…”

Section: Supramolecular Drug Carriersmentioning

confidence: 99%

Supramolecular nanoscale drug-delivery system with ordered structure

Jin

Zhu

Bai

et al. 2019

National Science Review

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Supramolecular chemistry provides a means to integrate multi-type molecules leading to a dynamic organization. The study of functional nanoscale drug-delivery systems based on supramolecular interactions is a recent trend. Much work has focused on the design of supramolecular building blocks and the engineering of supramolecular integration, with the goal of optimized delivery behavior and enhanced therapeutic effect. This review introduces recent advances in supramolecular designs of nanoscale drug delivery. Supramolecular affinity can act as a main driving force either in the self-assembly of carriers or in the loading of drugs. It is also possible to employ strong recognitions to achieve self-delivery of drugs. Due to dynamic controllable drug-release properties, the supramolecular nanoscale drug-delivery system provides a promising platform for precision medicine.

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“…Inspired by nature, supramolecular assembly through noncovalent recognition between molecular building blocks is very crucial for structural diversity and biological function, which becomes a robust tool to fabricate functional materials. − As a key branch of functional materials, supramolecular polymers via noncovalent interactions have peculiar molecular structure and physicochemical properties, and more importantly, they can achieve reversible transformation in response to diverse environmental stimuli. , This unique dynamic reversibility of supramolecular polymers makes it a promising delivery vehicle for tumor diagnosis and treatment. − Hereupon, a broad spectrum of supramolecular nonviral vectors in response to various stimuli have been designed and developed, ultimately revealing low cytotoxicity, efficient cellular internalization, and comparable transfection efficacy to that of traditional covalent polymers. − Very recently, we have constructed several stimuli-responsive supramolecular nonviral vectors that have fine biological properties and enhanced gene transfection efficacy. − Notably, all supramolecular nonviral vectors exhibit a trade-off between biological stability, i.e. , how efficient gene vectors are across cellular and tissue barriers, and dynamic reversibility, i.e.…”

Section: Introductionmentioning

confidence: 99%

Visible Light-Guided Gene Delivery with Nonviral Supramolecular Block Copolymer Vectors

Yasen,

Li,

Aini

et al. 2023

ACS Appl. Mater. Interfaces

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To achieve efficient gene delivery in vitro or in vivo, nonviral vectors should have excellent biostability across cellular and tissue barriers and also smart stimuli responsiveness toward controlled release of therapeutic genes into the cell nucleus. However, it remains a key challenge to effectively combine the biostability of covalent polymers with the stimuli responsiveness of noncovalent polymers into one nonviral vehicle. In this work, we report the construction of a kind of cationic supramolecular block copolymers (SBCs) through noncovalent polymerization of β-cyclodextrin/azobenzeneterminated pentaethylenehexamine (DMA-Azo-PEHA-β-CD) in aqueous media using β-CD-monosubstituted poly(ethylene glycol) (PEG-β-CD) as a supramolecular initiator. The resultant SBC exhibits superior biostability, biocompatibility, and light/pH dual-responsive characteristics, and it also demonstrates efficient plasmid DNA condensation capacity and the ability to rapidly release plasmid DNA into cells driven by visible light (450 nm). Eventually, this SBC-based delivery system demonstrates visible light-induced enhancement of gene delivery in both COS-7 and HeLa cells. We anticipate that this work provides a facile and robust strategy to enhance gene delivery in vitro or in vivo via visible light-guided manipulation of genes, further achieving safe, highly efficient, targeting gene therapy for cancer.

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Supramolecular block copolymers for gene delivery: enhancement of transfection efficiency by charge regulation

Cited by 11 publications

References 32 publications

Construction of Crowning β-cyclodextrin with Temperature Response and Efficient Properties of Host–Guest Inclusion

Construction of Crowning β-cyclodextrin with Temperature Response and Efficient Properties of Host–Guest Inclusion

Supramolecular nanoscale drug-delivery system with ordered structure

Visible Light-Guided Gene Delivery with Nonviral Supramolecular Block Copolymer Vectors

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