Supramolecular biofunctional materials

Zhou, Jie; Li, Jie; Du, Xuewen; Xu, Bing

doi:10.1016/j.biomaterials.2017.03.014

Cited by 200 publications

(126 citation statements)

References 340 publications

(359 reference statements)

Supporting

Mentioning

126

Contrasting

Order By: Relevance

“…166 After fibres selectively formed around cancer cells, they interacted with extrinsic cell death ligands and receptors, prompting cellular apoptosis. 173 An illustration of how EISA can produce a tumour inhibitory effect through the extracellular formation of nanofibrils can be seen in Figure 15. These studies all demonstrate the wide potential of EISA in targeting the tumour microenvironment and the ability of self-assembled structures alone to act as active cytotoxic agents.…”

Section: Small Molecule Sapdsmentioning

confidence: 99%

Self-assembling prodrugs

et al. 2017

View full text Add to dashboard Cite

Covalent modification of therapeutic compounds is a clinically proven strategy to devise prodrugs with enhanced treatment efficacies. This prodrug strategy relies on modified drugs that possess advantageous pharmacokinetic properties and administration routes over their parent drug. Self-assembling prodrugs represent an emerging class of therapeutic agents capable of spontaneously associating into well-defined supramolecular nanostructures in aqueous solutions. The self-assembly of prodrugs expands the functional space of conventional prodrug design, providing a possible pathway to more effective therapies as the assembled nanostructure possesses distinct physicochemical properties that can be tailored to specific administration routes and disease treatment. In this review, we will discuss the various types of self-assembling prodrugs in development, providing an overview of the methods used to control their structure and function and, ultimately, our perspective on their current and future potential.

show abstract

Section: Small Molecule Sapdsmentioning

confidence: 99%

Self-assembling prodrugs

et al. 2017

View full text Add to dashboard Cite

show abstract

“…For instance, natural amyloid proteins such as amyloid‐β peptide (Aβ) and tau protein form similar fibrous assemblies that consist of β‐sheet‐rich sequences . Inspired by the natural fibers that are formed by the self‐assembly of building block units, artificial peptide nanofibers have been developed for various applications in the fields of biomedicine, tissue engineering, renewable energy, environmental science, nanotechnology, and material science ,,,. Advantages of the peptide‐based nanofibers compared with other polymeric nanofibers include that (1) the nanofiber‐forming peptide units are known and can be chemically tuned, and (2) stimulus‐responsive groups can be introduced to the peptide moiety to control the structures of the nanofibers.…”

Section: Self‐assembled Peptide Nanofibersmentioning

confidence: 99%

Peptide Nanomaterials Designed from Natural Supramolecular Systems

Inaba

Matsuura

2018

The Chemical Record

View full text Add to dashboard Cite

Natural supramolecular assemblies exhibit unique structural and functional properties that have been optimized over the course of evolution. Inspired by these natural systems, various bio‐nanomaterials have been developed using peptides, proteins, and nucleic acids as components. Peptides are attractive building blocks because they enable the important domains of natural protein assemblies to be isolated and optimized while retaining the original structures and functions. Furthermore, the peptide subunits can be conjugated with exogenous molecules such as peptides, proteins, nucleic acids, and metal nanoparticles to generate advanced functions. In this personal account, we summarize recent progress in the construction of peptide‐based nanomaterial designed from natural supramolecular systems, including (1) artificial viral capsids, (2) self‐assembled nanofibers, and (3) protein‐binding motifs. The peptides inspired by nature should provide new design principles for bio‐nanomaterials.

show abstract

“…[24] Among them, FF dipeptides have drawn much attention due to their unusual chemical and physical properties and their very short length that can endow expandability toward hybridization with other motifs. [24] Among them, FF dipeptides have drawn much attention due to their unusual chemical and physical properties and their very short length that can endow expandability toward hybridization with other motifs.…”

Section: Introductionmentioning

confidence: 99%

Tyrosine‐Rich Peptides as a Platform for Assembly and Material Synthesis

et al. 2018

View full text Add to dashboard Cite

The self‐assembly of biomolecules can provide a new approach for the design of functional systems with a diverse range of hierarchical nanoarchitectures and atomically defined structures. In this regard, peptides, particularly short peptides, are attractive building blocks because of their ease of establishing structure–property relationships, their productive synthesis, and the possibility of their hybridization with other motifs. Several assembling peptides, such as ionic‐complementary peptides, cyclic peptides, peptide amphiphiles, the Fmoc‐peptide, and aromatic dipeptides, are widely studied. Recently, studies on material synthesis and the application of tyrosine‐rich short peptide‐based systems have demonstrated that tyrosine units serve as not only excellent assembly motifs but also multifunctional templates. Tyrosine has a phenolic functional group that contributes to π–π interactions for conformation control and efficient charge transport by proton‐coupled electron‐transfer reactions in natural systems. Here, the critical roles of the tyrosine motif with respect to its electrochemical, chemical, and structural properties are discussed and recent discoveries and advances made in tyrosine‐rich short peptide systems from self‐assembled structures to peptide/inorganic hybrid materials are highlighted. A brief account of the opportunities in design optimization and the applications of tyrosine peptide‐based biomimetic materials is included.

show abstract

Supramolecular biofunctional materials

Cited by 200 publications

References 340 publications

Self-assembling prodrugs

Self-assembling prodrugs

Peptide Nanomaterials Designed from Natural Supramolecular Systems

Tyrosine‐Rich Peptides as a Platform for Assembly and Material Synthesis

Contact Info

Product

Resources

About