“…The PDAs are not only pH- and thermochromic but also photo-, mechano-, and radiochromic, , dominated by a transition between a nonemissive form, sometimes called the “blue” form, and a fluorescent state (“red” form) . Applications such as organic electronics, − biosensors, , paper sensors, bioimaging, , and delivery of drugs or biomolecules have also been developed, but the major area of applications is the detection of chemicals such as volatile organic compounds and biorelated species such as bacteria , and viruses. , More recently, major advances have been made in the field of food biotechnology and security. , Although the importance of incorporating functional side arms to the conjugated backbone was clearly stressed, − surprisingly, the use of chiral groups has attracted only a modest attention. − It is noteworthy that chiral pendants can act as functional groups in PDAs, but interestingly, they can also act as supramolecular units programming specific preferential packing arrangements in the crystalline state prior to photopolymerization of the diacetylene (DA) monomers. To the best of our knowledge, this latter important application appears to be relatively neglected.…”