Supramolecular assemblies of multifunctional microgels for biomedical applications

Zheng, Jingxia; Zhu, Canjie; Xu, Xun; Wang, Xinwei

doi:10.1039/d3tb00346a

Cited by 6 publications

(5 citation statements)

References 196 publications

(287 reference statements)

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“…Microgels are emerging as multifunctional platforms for assembling cells and tissue-engineered microenvironments possessing exceptional features, such as increased water content, tunable microporous architecture, and enhanced nutrient transport due to their high surface area and heterogeneity. [33,34] These properties enable microgels to address the existing drawbacks of conventional scaffolds, which inhibit the penetration of cells and blood vessels, thereby compromising biological activity and endogenous healing performance. [35,36] Initially, microhydrogels were fabricated by the photopolymerization of LAMPL hydrogel (1:2) precursor solution using photomasks (Figure S4A, Supporting Information) as one of most well-known techniques in microfabrication due to low-cost process.…”

Section: Freestanding Microgelsmentioning

confidence: 99%

A Self‐Sustaining Hydrogels with Autonomous Supply of Nutrients and Bioactive Domains for 3D Cell Culture

Zargarzadeh,

Gomes,

Patrício

et al. 2023

Adv Funct Materials

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Photo‐crosslinkable platelet lysate (PL)‐based hydrogels have been proven to support human‐derived cell cultures owing to their high content of bioactive molecules, such as cytokines and growth factors. As a unique self‐maintained and biocompatible 3D scaffold, the recently reported self‐feeding hydrogels with enzyme‐empowered degradation capacity have shown high biological performance in vitro and in vivo. To take advantage of all features of both PL and self‐feeding hydrogels, here UV responsive laminaran‐methacrylate (LamMA) and PL‐methacrylate (PLMA) derivatives plus glucoamylase (GA), which significantly improve the overall features of a 3D system, is coupled. This self‐sustaining hybrid hydrogel emerges as a unique scaffold due to the sustained delivery of glucose produced via enzymatic degradation of laminaran while granting the release of growth factors through the presence of PL. This biomaterial is applied to fabricate high‐throughput freestanding microgels with controlled geometric shapes. Furthermore, this multicomponent hybrid hydrogel is successfully implemented as the first reported glucose supplier bioink to manufacture intricate and precisely defined cell‐laden structures using a support matrix. Finally, such hydrogels are utilized as a proof of concept to serve as 3D in vitro cancer models, with the aim of recapitulating the tumor microenvironment.

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Section: Freestanding Microgelsmentioning

confidence: 99%

A Self‐Sustaining Hydrogels with Autonomous Supply of Nutrients and Bioactive Domains for 3D Cell Culture

Zargarzadeh,

Gomes,

Patrício

et al. 2023

Adv Funct Materials

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“…There has been a recent interest in using thermo‐responsive polymers for removing water from the air. [ 10–24 ] Previous modeling work by Zeng et al. [ 20 ] and Kocher et al.…”

Section: Introductionmentioning

confidence: 99%

“…Experimental TR desiccant studies have primarily targeted atmospheric water harvesting applications. [ 10–19 ] These materials have been hypothesized to become a disruptive technology if water can be captured in the vapor form and then released as a liquid (which has some synthetic challenges discussed in Section 4.3). [ 30 ] However, these works focused on 1) the IPN polymer architecture at 2) specific RH values and temperatures, rather than exploring different polymer architectures and their performance over the full range of RHs and temperatures [ 10–19 ] needed in dehumidification applications (Section S1, Supporting Information).…”

Section: Introductionmentioning

confidence: 99%

“…[ 10–19 ] These materials have been hypothesized to become a disruptive technology if water can be captured in the vapor form and then released as a liquid (which has some synthetic challenges discussed in Section 4.3). [ 30 ] However, these works focused on 1) the IPN polymer architecture at 2) specific RH values and temperatures, rather than exploring different polymer architectures and their performance over the full range of RHs and temperatures [ 10–19 ] needed in dehumidification applications (Section S1, Supporting Information). Additionally, our simulations only consider polymers that both sorb and desorb water in the vapor phase (in contrast to sorbing as a vapor and desorbing as a liquid), as the only polymers that exhibited liquid water release showed poor cyclability and liquid water release is not necessary for improved efficiency.…”

Section: Introductionmentioning

confidence: 99%

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Engineered Polymer Architectures for Thermo‐Responsive Desiccants in Dehumidification Applications

Meyer

Cui

Zeng

et al. 2023

Advanced Energy Materials

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Humidity control is relevant to many processes in buildings and manufacturing and is responsible for over 600 million tons of CO2 annually. As such, desiccants that can efficiently remove moisture from air can greatly reduce emissions. A new class of desiccant materials, thermo‐responsive desiccants, has been of increased interest in the literature. These materials are generally based on thermo‐responsive polymers and exhibit a temperature‐dependent isotherm, an attribute that is small in traditional desiccants. In this work, seven key parameters needed to create an effective thermo‐responsive polymer desiccant are identified using a combination of modeling and experimental data. It is found that more thermo‐responsiveness is not necessarily better for energy efficiency, and that an optimal, “medium” value is desired. Additionally, polymer composition and architecture play key roles in adjusting the seven key parameters. Finally, based on findings from both modeling and experimental work, guidelines on synthesizing future thermo‐responsive polymer desiccants are presented.

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“…Polymeric microgels, produced via the microfluidics technique, have emerged as a fascinating area of research in materials science and biotechnology [1][2][3]. These miniature hydrogel particles, typically ranging from hundreds of nanometers to a few micrometers in size, impart unique properties that make them vital in a wide range of applications [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Porous Microgels for Delivery of Curcumin: Microfluidics-Based Fabrication and Cytotoxicity Evaluation

Orbay,

Sanyal,

Sanyal

2023

Micromachines

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Polymeric microgels, fabricated via microfluidic techniques, have garnered significant interest as versatile drug delivery carriers. Despite the advances, the loading and release of hydrophobic drugs such as curcumin from polymeric microgels is not trivial. Herein, we report that effective drug loading can be achieved by the design of porous particles and the use of supramolecular cyclodextrin-based curcumin complexes. The fabrication of porous microgels through the judicious choice of chemical precursors under flow conditions was established. The evaluation of the curcumin loading dependence on the porosity of the microgels was performed. Microgels with higher porosity exhibited better curcumin loading compared to those with lower porosity. Curcumin-loaded microgels released the drug, which, upon internalization by U87 MG human glioma cancer cells, induced cytotoxicity. The findings reported here provide valuable insights for the development of tailored drug delivery systems using a microfluidics-based platform and outline a strategy for the effective delivery of hydrophobic therapeutic agents such as curcumin through supramolecular complexation.

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Supramolecular assemblies of multifunctional microgels for biomedical applications

Abstract: Biomedical materials with outstanding biochemical and mechanical properties have great potential in tissue enginering, drug delivery, antibacterial, and implantable devices. Hydrogels have emerged as a most promising family of biomedical...

Cited by 6 publications

References 196 publications

A Self‐Sustaining Hydrogels with Autonomous Supply of Nutrients and Bioactive Domains for 3D Cell Culture

A Self‐Sustaining Hydrogels with Autonomous Supply of Nutrients and Bioactive Domains for 3D Cell Culture

Engineered Polymer Architectures for Thermo‐Responsive Desiccants in Dehumidification Applications

Porous Microgels for Delivery of Curcumin: Microfluidics-Based Fabrication and Cytotoxicity Evaluation

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