Supramolecular Architecture

Bein, Thomas

doi:10.1021/bk-1992-0499

Cited by 55 publications

(1 citation statement)

References 12 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The intestinal epithelial barrier is composed of apical intercellular junctional proteins known as tight junctions (TJ) and associated proteins known as the adherens junctions. The TJ are composed of transmembrane proteins (e.g., claudins), integral membrane proteins (e.g., occludin), junction adhesion molecules, and cytoplasmic zona occludens (ZO) proteins (e.g., ZO-1, -2 and-3) which connect the TJ complex intracellularly with the actin cytoskeleton [23]. Disruption in these proteins may allow for the paracellular transport of endotoxin from the gut lumen to the liver via the portal vein.…”

Section: Resultsmentioning

confidence: 99%

A Designer Synbiotic Attenuates Chronic-Binge Ethanol-Induced Gut-Liver Injury in Mice

et al. 2019

View full text Add to dashboard Cite

Gut dysbiosis and altered short-chain fatty acids are associated with ethanol-induced liver injury. SCFA are fermentation byproducts of the gut microbiota known to have many beneficial biological effects. We tested if a designer synbiotic could protect against ethanol-induced gut-liver injury. C57BL/6 female mice were exposed to chronic-binge ethanol feeding consisting of ethanol (5% vol/vol) for 10 days, followed by a single gavage (5 g/kg body weight) 6 h before euthanasia. A group of mice also received oral supplementation daily with a designer synbiotic, and another group received fecal slurry (FS); control animals received saline. Control mice were isocalorically substituted maltose dextran for ethanol over the entire exposure period. Ethanol exposure reduced expression of tight junction proteins in the proximal colon and induced hepatocyte injury and steatosis. Synbiotic supplementation not only mitigated losses in tight junction protein expression, but also prevented ethanol-induced steatosis and hepatocyte injury. Ethanol exposure also increased hepatic inflammation and oxidative stress, which was also attenuated by synbiotic supplementation. Mice receiving FS were not protected from ethanol-induced liver injury or steatosis. Results were associated with luminal SCFA levels and SCFA transporter expression in the proximal colon and liver. These results indicate supplementation with a designer synbiotic is effective in attenuating chronic-binge ethanol-induced gut-liver injury and steatosis in mice, and highlight the beneficial effects of the gut microbial fermentation byproducts.

show abstract

Section: Resultsmentioning

confidence: 99%

A Designer Synbiotic Attenuates Chronic-Binge Ethanol-Induced Gut-Liver Injury in Mice

et al. 2019

View full text Add to dashboard Cite

show abstract

Novel Single- and Double-Layer and Three-Dimensional Structures of Rare-Earth Metal Coordination Polymers: The Effect of Lanthanide Contraction and Acidity Control in Crystal Structure Formation

Pan

Huang

Li³

et al. 2000

Angewandte Chemie

View full text Add to dashboard Cite

The concept of rational design of micro-and mesoporous and other functional materials has attracted much attention because of the potential of these materials in various applications, such as molecular magnets, nonlinear optical devices, catalysts, molecular sieves, and sensors. [1] The construction of coordination networks possessing zeolite-or claylike structures offers great challenges and opportunities in terms of controlling their shape and size for selective adsorption. Much of the work has so far been focused on coordination polymers containing transition metal (Groups 8 to 10) and post-transition metal (Groups 11 and 12) elements including Fe, Co, Ni, Cu, Ag, Zn, Cd, and Hg. Rare-earth metal compounds have seldom been investigated. [2] To date, no systematic investigation across the lanthanide series with a single ligand has been carried out. Due to their high coordination number and special magnetic and fluorescence properties, the lanthanide series is likely to provide new materials that possess specific properties and desired features. In this communication, we report the hydrothermal synthesis, structures, and properties of six novel lanthanide coordination polymers and the investigation of the effects of lanthanide contraction and solution pH on the crystal structures of these compounds.Hydrothermal synthesis [3] is an effective and promising method for growing crystals of numerous inorganic compounds. Recently, we and others have successfully grown single crystals of a variety of transition metal coordination polymers using this approach. [4, 5] Our exploratory studies also show that the hydrothermal environment is suitable for preparation of lanthanide compounds.In this work, we have chosen a single, multifunctional ligand, 3,5-pyrazoledicarboxylic acid (H 3 pdc, 1), based on the following considerations: a) it has multiple coordination sites that allow structures of higher dimensions; b) it has an asymmetric geometry that may lead to acentric crystal structures; and c) it has abstractable protons that allow various, acidity-dependant coordination modes. In general, the lanthanide series can be divided into three groups according to their masses: the lighter La ± Pm (Group 1), the intermediate Sm ± Dy (Group 2), and the heavier Ho ± Lu (Group 3). Representative metals from each Group were selected and investigated.In a typical reaction 0.25 mmol of rare-earth metal(iii) nitrate and 0.25 mmol of 1 in 10 mL H 2 O was used. The mixture was placed into a 23 mL acid-digestion bomb lined with Teflon and heated at 150 8C for 3 days. Reactions with Group 1 lanthanide nitrates Ln(NO 3 ) 3 (Ln La, Ce) generated [Ln 2 (Hpdc) 3 (H 2 O) 4 ]´2 H 2 O, Ln La (2), Ln Ce (3). Group 2 nitrate Eu(NO 3 ) 3 produced [Eu 2 (Hpdc) 3 (H 2 O) 6 ] (4) and a minor product [Eu 2 (Hpdc) 3 (H 2 O) 4 ]´2 H 2 O that is isostructural to 2 and 3, while Group 3 nitrates Ln(NO 3 ) 3 (Ln Er, Lu) yielded [Er 2 (Hpdc) 3 (H 2 O) 6 ] (5), and [Ln(Hpdc)(H 2 pdc)(H 2 O) 2 ], Ln Er (6), Ln Lu (7).Single-phase polycrystalline samples of bo...

show abstract

Novel Single- and Double-Layer and Three-Dimensional Structures of Rare-Earth Metal Coordination Polymers: The Effect of Lanthanide Contraction and Acidity Control in Crystal Structure Formation

Pan

Huang

Li³

et al. 2000

Angewandte Chemie International Edition

404

View full text Add to dashboard Cite

show abstract

Supramolecular Architecture

Cited by 55 publications

References 12 publications

A Designer Synbiotic Attenuates Chronic-Binge Ethanol-Induced Gut-Liver Injury in Mice

A Designer Synbiotic Attenuates Chronic-Binge Ethanol-Induced Gut-Liver Injury in Mice

Novel Single- and Double-Layer and Three-Dimensional Structures of Rare-Earth Metal Coordination Polymers: The Effect of Lanthanide Contraction and Acidity Control in Crystal Structure Formation

Novel Single- and Double-Layer and Three-Dimensional Structures of Rare-Earth Metal Coordination Polymers: The Effect of Lanthanide Contraction and Acidity Control in Crystal Structure Formation

Contact Info

Product

Resources

About