Supramolecular aggregates formed by sulfadiazine and sulfisomidine inclusion complexes with α- and β-cyclodextrins

Rajendiran, N.; Venkatesh, G.; Saravanan, J.

doi:10.1016/j.saa.2014.03.028

Cited by 17 publications

(14 citation statements)

References 32 publications

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“…Later similar SA structures of CD nanotubes have also been reported by some other research groups [26][27][28][29][30][31][32][33]. Jaffer et al and Sowmiya et al found that trans-2-[4-(dimethylamino)styryl]benzothiazole (DMASBT) could induce the formation of CD nanotubes and their rodlike SA [26][27][28], although they suggested that the SA consisted of nanotubes filled with DMASBT only and no empty CD was involved [28].…”

Section: Introductionsupporting

confidence: 63%

“…The thickness of the nanosheets is about 30-40 nm, so it should be noted that the nanosheet is not a single layer but a bulk aggregation of nanotubes. In comparison, Rajendiran et al also fabricated nanosheets using a series of non-ionic drug molecules and CDs [30][31][32]. They also proposed the ''secondary self-assembly'' mechanism [32] while the shape of their nanosheets was irregular.…”

Section: Driving Forces For Self-assemblymentioning

confidence: 99%

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Secondary assembly mechanism of cyclodextrin based on LiNTf2@β-CD system

Shi

Shen

2016

J Incl Phenom Macrocycl Chem

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Cyclodextrin-based nanotubes have been widely investigated and their secondary assembly (SA) behavior was found in our previous works. Here we report the self-assembly behavior between lithium bis(trifluoromethylsulfonyl)imide (LiNTf 2 ) and b-cyclodextrin (b-CD). Nanosheet structures with regular shape were obtained in the concentrated LiNTf 2 @b-CD solution. This phenomenon can be explained in terms of the SA mechanism of CD induced by the inorganic guest LiNTf 2 . LiNTf 2 and b-CD firstly forms nanotubes, and the nanotubes further stack with each other to form nanosheets by SA. We confirm that the hydrogen-bonding interaction contributes a lot to the formation of the nanotubes and their SA, and Li ? shows a special effect in the SA by inducing hydrogenbonding network between the adjacent b-CD to regularly pack the nanotubes.

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Section: Introductionsupporting

confidence: 63%

Section: Driving Forces For Self-assemblymentioning

confidence: 99%

Secondary assembly mechanism of cyclodextrin based on LiNTf2@β-CD system

Shi

Shen

2016

J Incl Phenom Macrocycl Chem

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“…Both sulfa drugs exhibit similar absorption maxima; this is because tautomeric structure is present in both drug molecules [20][21][22][23][24][25]. With an increasing the concentration of SM and SMT, the absorption maximum of both sulfa drugs was completely lost whereas BSA and adenine absorbance was decreased at the same wavelength; i.e., in varying concentration of sulfa drugs, no remarkable spectral shift was noticed in BSA and adenine except a decrease in the intensity.…”

Section: Absorption Spectroscopic Studiesmentioning

confidence: 99%

“…This approach originally developed to illuminate the structure and the excited state behavior of organic molecules and drugs included in cyclodextrin macrocycles through experimental and theoretical [20][21][22][23][24][25][26] explorations. In the view of increasing attention directed toward the importance of investigating interaction between proteins and drugs, we present in this work utilizing UV-visible and fluorescence spectroscopy, cyclic voltammetry and molecular docking studies for investigating the interaction between SM/SMT with BSA/adenine.…”

Section: Introductionmentioning

confidence: 99%

Binding of Sulfamerazine and Sulfamethazine to Bovine Serum Albumin and Nitrogen Purine Base Adenine: A Comparative Study

Rajendiran

Thulasidhasan

2015

ILCPA

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ABSTRACT. Quenching of bovine serum albumin (BSA) and DNA base (adenine) by sulfamerazine (SM) and sulfamethazine (SMT) was studied using UV-visible, fluorescence cyclic voltammetry and molecular docking methods. A strong fluorescence quenching reaction of SM and SMT to BSA/adenine was observed and the quenching mechanism was suggested as static. Both drugs can bind to BSA and adenine with stoichiometric ratio of 1:1 and the protein -drug complexes are stabilized mainly by hydrogen bonds and van der Waals interaction. Compared to SM, SMT contributes substantially higher binding efficiency with BSA/adenine. With addition of drug solution to the adenine/BSA, the oxidation and the reduction peaks shifted towards high and low potentials, respectively. R o , J, r and E values in the BSA-drugs are higher than that of adeninedrug molecules suggest that binding of the sulfa drugs with BSA is higher than adenine -drug molecules. Docking method specify that bioactive site of sulfa drugs moiety, the aniline group is interacted with the BSA molecules.

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“…By forming noncovalent inclusion complexes and by the coalescence of guest polymers in their complexes, sophisticated nanostructured and functionalised polymers that are distinct from their bulk materials have been obtained from solutions and melts of CDs. [4][5][6][7] Over the past few years, nanofibres containing CDs or their inclusion compounds with low-or high-molecular-weight guests have been widely reported; 8 they are classified into four types: polymer/CD nanofibres, carrier-free CD nanofibres, polymer/CD-inclusion complex nanofibres and polymer/polymer/ CD-inclusion complex nanofibres. By using CD technology, higher crystallinity and crystallizability have been achieved compared with nanofibres formed from neat polymers.…”

Section: Introductionmentioning

confidence: 99%

Self-organisation and characterisation of hierarchical structures in trimethyl β-cyclodextrin nano-films

Ogawa

Ashida

Kaneko

et al. 2018

Mater. Chem. Front.

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Despite the numerous materials that have been developed, controlling the self-organisation and detailed characterisation of hierarchical nanostructures composed of various functional molecular units remains a challenging task. Herein, we report a facile approach for creating flat nanosheets and helical nanofibres for ultrathin films (ca. 12 nm) and thin films (ca. 120 nm), respectively. These films contain a member of the cyclodextrin family, trimethyl b-cyclodextrin (TMCD), and form via self-organisation with heating (thermal annealing) in the absence of both polymeric components and organic solvent. X-ray reflectivity (XRR) and grazing-incident-angle X-ray diffraction (GIXD) readily explain the characteristic molecular assembling behaviour in the thin films, such as the highly perpendicularly ordered polycrystalline structure of the nanosheet crystal films and the dewetting behaviour for the fabrication of bundled nanofibres. In addition to X-ray analysis, scanning electron microscopy (SEM) and atomic-force microscopy (AFM) imaging reveals that the obtained nanofibres are well rounded and partially double or triple-helical coiled, with highly frustrated characteristics. The surface homogeneity prior to the thermal annealing was found to be crucial to determine the creation of the helical nanofibre structure. Also, the results suggest the importance of the absence of solvent vapour for the creation of the helical nanofibres. Thus, this report proposes a facile self-organisation process for creating polymer-free cyclodextrin-based nanostructures that should have wide applications. It also shows the effectiveness of X-ray analyses combined with several surfacesensitive X-ray techniques and microscopy observations.

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Supramolecular aggregates formed by sulfadiazine and sulfisomidine inclusion complexes with α- and β-cyclodextrins

Cited by 17 publications

References 32 publications

Secondary assembly mechanism of cyclodextrin based on LiNTf2@β-CD system

Secondary assembly mechanism of cyclodextrin based on LiNTf2@β-CD system

Binding of Sulfamerazine and Sulfamethazine to Bovine Serum Albumin and Nitrogen Purine Base Adenine: A Comparative Study

Self-organisation and characterisation of hierarchical structures in trimethyl β-cyclodextrin nano-films

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