Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI

Accardo, Antonella; Tesauro, Diego; Aloj, Luigi; Pedone, Carlo; Morelli, Giancarlo

doi:10.1016/j.ccr.2009.01.015

Cited by 125 publications

(124 citation statements)

References 134 publications

Supporting

Mentioning

119

Contrasting

Order By: Relevance

“…Generally, compared with Gd(III)-entrapped in liposomes, Gd(III) has proven to show higher ionic relaxivity when Gd(III) was on the surface of liposome. 40 Due to the release of Gd(III) triggered by laser, more Gd(III) was accumulated in tumor cells and a shortened T1 was observed. These results indicated that the laser irradiation could induce stronger MRI and CT contrast effect in tumors compared to that without irradiation, and suggest that the LTCAs have satisfactory light-triggered response contrast enhancement effect, which indicated the great potential application in responsive CT/MRI imaging.…”

mentioning

confidence: 99%

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Wu¹,

Wang²,

Lu³

et al. 2017

IJN

View full text Add to dashboard Cite

The major challenge in current clinic contrast agents (CAs) and chemotherapy is the poor tumor selectivity and response. Based on the self-quench property of IR820 at high concentrations, and different contrast effect ability of Gd-DOTA between inner and outer of liposome, we developed “bomb-like” light-triggered CAs (LTCAs) for enhanced CT/MRI/FI multimodal imaging, which can improve the signal-to-noise ratio of tumor tissue specifically. IR820, Iohexol and Gd-chelates were firstly encapsulated into the thermal-sensitive nanocarrier with a high concentration. This will result in protection and fluorescence quenching. Then, the release of CAs was triggered by near-infrared (NIR) light laser irradiation, which will lead to fluorescence and MRI activation and enable imaging of inflammation. In vitro and in vivo experiments demonstrated that LTCAs with 808 nm laser irradiation have shorter T 1 relaxation time in MRI and stronger intensity in FI compared to those without irradiation. Additionally, due to the high photothermal conversion efficiency of IR820, the injection of LTCAs was demonstrated to completely inhibit C6 tumor growth in nude mice up to 17 days after NIR laser irradiation. The results indicate that the LTCAs can serve as a promising platform for NIR-activated multimodal imaging and photothermal therapy.

show abstract

mentioning

confidence: 99%

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Wu¹,

Wang²,

Lu³

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][6][7] Fluorescent probes are powerful tools for organism imaging because of the rapidity and sensitivity of fluorescence. [4,7] Contrast agents are used in MRI to enhance signal contrast by changing the relaxation time of the tissue water, rendering the area of interest more conspicuous than the surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

Fe²⁺‐Responsive Bimodal MRI and Fluorescent Imaging Probe Based on a Gadolinium(III) Complex

2015

View full text Add to dashboard Cite

An Fe2+ -responsive bimodal MRI and fluorescent imaging probe, Gd-DTTA-BPP (DTTA = diethylenetriamine-N,N,NЈЈ,NЈЈ-tetraacetate, BPP = 2-{4-[(2,2Ј-bipyridin)-5-ylethynyl]phenoxy}-N-ethylacetamide), has been synthesized and characterized and its relaxivity and fluorescence properties examined. Gd-DTTA-BPP displays a high relaxation efficiency (10.3 mM -1 s -1 at 23 MHz and 25°C) as a result of its rigid ligand and two inner-sphere water molecules

show abstract

“…Gd-based complexes, such as Gd(III)-DOTA and Gd(III)-DTPA using paramagnetic material, are known as the most effective T 1 -agents. 10 The MR images of contrast agents are based on the same principles of nuclear magnetic resonance (NMR). The MR image of contrast agents is related to relaxation behavior of hydrogen nuclei of water.…”

mentioning

confidence: 99%

“…Generally, Gd(III) complexes on the liposomal surface are known to improve ionic relaxivity compared to Gd(III)-entrapped liposomes. 10 The nuclear magnetic resonance dis- persion (NMRD) profiles of liposomal contrast agents show a typical peak at higher frequencies.…”

mentioning

confidence: 99%

Dual Functional Gd(III)-DOTA Liposomes for Cancer Therapy and Diagnosis as a Theragnostic Carrier

Han¹,

Jung²,

Seong³

et al. 2013

Bulletin of the Korean Chemical Society

View full text Add to dashboard Cite

Development of dual functional liposome has been studied for cancer theragnostics. Therefore, we focused on ultrasound-sensitive liposomes with doxorubicin (DOX) and gadolinium (Gd) as a theragnostic carrier having a potential for cancer therapy and diagnosis. In this study, Gd(III)-DOTA-modified sonosensitive liposomes (GL) was developed using chemically synthesized Gd(III)-DOTA-DPPE lipid. Sonosensitivity of GL to 1 MHz ultrasound induced 25% of DOX release. The relaxivities (r 1 ) of GL were 7.33-10.34 mM, which was higher than that of MR-bester ® . Intracellular delivery of DOX from GL by ultrasound irradiation was evaluated according to ultrasound intensity, resulting in increase of uptake of DOX released from ultrasoundtriggered GLs compared to GL3 or Doxil ® without ultrasound. Taken together, this study shows that the paramagnetic and sonosensitive liposomes, GL, is a novel and highly effective delivery system for drug with the potential for broad applications in human disease.

show abstract

Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI

Cited by 125 publications

References 134 publications

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Fe²⁺‐Responsive Bimodal MRI and Fluorescent Imaging Probe Based on a Gadolinium(III) Complex

Dual Functional Gd(III)-DOTA Liposomes for Cancer Therapy and Diagnosis as a Theragnostic Carrier

Contact Info

Product

Resources

About

Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI

Cited by 125 publications

References 134 publications

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Fe2+‐Responsive Bimodal MRI and Fluorescent Imaging Probe Based on a Gadolinium(III) Complex

Dual Functional Gd(III)-DOTA Liposomes for Cancer Therapy and Diagnosis as a Theragnostic Carrier

Contact Info

Product

Resources

About

Fe²⁺‐Responsive Bimodal MRI and Fluorescent Imaging Probe Based on a Gadolinium(III) Complex