Suprachoroidale Hydrogelplombe – eine neue minimalinvasive Technik zur Behandlung der rhegmatogenen Netzhautablösung

Boden, Karl; Januschowski, Kai; Szurman, Peter

doi:10.1055/s-0043-102947

Cited by 1 publication

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering these limitations, suprachoroidal hydrogel buckling has arisen as a promising alternative. Suprachoroidal hydrogel buckling has been explored by Szurman et al using a cross-linked HA gel in both rabbits and in 21 patients with unilateral RRD [ 105 , 106 , 107 ]. In both cases, the gels were well tolerated, with a normal IOP and no visible retinal damage.…”

Section: Suprachoroidal Drug Delivery Systemsmentioning

confidence: 99%

“…The cross-linked gel showed visible buckling for approximately 8 weeks compared to around 1 week for a non-crosslinked gel. Retinal reattachment was observed in all but one patient at 8 weeks [ 107 ]. The formulated hydrogel is biocompatible, as HA is a significant native component of the eye and is also self-absorbable, allowing for safe biodegradability.…”

Section: Suprachoroidal Drug Delivery Systemsmentioning

confidence: 99%

See 1 more Smart Citation

Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges

Wu,

Akbar,

Giunta

et al. 2023

Materials

View full text Add to dashboard Cite

The human eye’s intricate anatomical and physiological design necessitates tailored approaches for managing ocular diseases. Recent advancements in ophthalmology underscore the potential of hydrogels as a versatile therapeutic tool, owing to their biocompatibility, adaptability, and customizability. This review offers an exploration of hydrogel applications in ophthalmology over the past five years. Emphasis is placed on their role in optimized drug delivery for the posterior segment and advancements in intraocular lens technology. Hydrogels demonstrate the capacity for targeted, controlled, and sustained drug release in the posterior segment of the eye, potentially minimizing invasive interventions and enhancing patient outcomes. Furthermore, in intraocular lens domains, hydrogels showcase potential in post-operative drug delivery, disease sensing, and improved biocompatibility. However, while their promise is immense, most hydrogel-based studies remain preclinical, necessitating rigorous clinical evaluations. Patient-specific factors, potential complications, and the current nascent stage of research should inform their clinical application. In essence, the incorporation of hydrogels into ocular therapeutics represents a seminal convergence of material science and medicine, heralding advancements in patient-centric care within ophthalmology.

show abstract

Section: Suprachoroidal Drug Delivery Systemsmentioning

confidence: 99%

Section: Suprachoroidal Drug Delivery Systemsmentioning

confidence: 99%