Supra-molecular agents running tasks intelligently (SMARTI): recent developments in molecular logic-based computation

Abstract

The field of molecular information handling and processing from a Boolean starting point has grown strongly during the past five years to make important contributions to the areas of intracellular...

Molecular engineering of fluorescent bichromophore 1,3,5-triaryl-Δ2-pyrazoline and 4-amino-1,8-naphthalimide molecular logic gates

“…39,40 The truth table is given in Table 2. Binding constants were determined by fluorimetric titration using the Henderson-Hasselbalch equation modified for spectroscopic analysis, eqn (6) log[(I max À I)/(I À I min )] = Àlog[M + ] + log b M+ (6) where the log b M+ is the negative logarithm of the H + dissociation constant (or Fe 3+ apparent constant), I max and I min are the maximum and minimum fluorescence intensity and I is the intensity at a specific wavelength. Sigmoidal-shaped titration curves were observed in all cases (Fig.…”

“…75 A pb H + of 4.0 was determined for the N,N-dimethylaniline receptor of 2. For 3 linearised fitting to eqn (6) in the presence of 10 À2 M H + provided an apparent binding constant pb Fe 3+ of 4.3.…”

“…Molecular and supramolecular logic gates based on fluorescence modulation are of considerable interest in cell biology, medicine, environmental diagnostics, and material science. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] Two complementary paradigms for molecular logic gate design are photoinduced electron transfer (PET) [15][16][17][18] and internal charge transfer (ICT). [19][20][21] From the integration of the fluorophore-spacer-receptor and fluorophore-receptor formats, associated with these two mechanisms, molecules with more complex structures and functions can be engineered.…”

A Highly Water-Soluble and Solid State Emissive 1,8-Naphthalimide as a Fluorescent PET Probe for Determination of pHs, Acid/Base Vapors, and Water Content in Organic Solvents

“…The used approaches were based on intramolecular charge transfer (ICT), photoinduced electron transfer (PET), twisted intramolecular charge transfer (TICT), fluorescence resonance energy transfer (FRET), excited-state intramolecular proton transfer (ESIPT), and aggregation-induced emission [16][17][18][19][20][21][22][23][24]. Notably, the PET using the "fluorophore-spacer-receptor" format was recognized as the most popular platform for the design of fluorescence chemosensing probes [25][26][27][28]. This model was distinguished by simple construction and easier and predictable communication between the receptor (recognition part) and the fluorophore (signaling part).…”

Fluorescent Molecular Logic Gates Driven by Temperature and by Protons in Solution and on Solid

“…The appeal of molecular logic‐based computation [1–22] is now spreading beyond chemistry laboratories into the molecular biology community [23–31] . Molecular logic systems are being applied increasingly in cell physiology [32–40] .…”