Suppurative Thrombophlebitis: A New Look at a Continuing Problem

Js, Hammond; Varas, Robin; Cg, Ward

doi:10.1097/00007611-198808000-00007

Cited by 9 publications

(5 citation statements)

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“…Classically, suppurative thrombophlebitis is the result of venous instrumentation during intravenous drug injection or catheter insertion in critically ill patients 8, 9, 10, 11, 12. Our patient's venous ulcer may have been the source of her MRSA infection.…”

Section: Discussionmentioning

confidence: 87%

Surgical resection for suppurative thrombophlebitis of the great saphenous vein after radiofrequency ablation

Grady

Aizpuru

Farley

et al. 2019

Journal of Vascular Surgery Cases, Innovations and Techniques

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Radiofrequency ablation has become one of the most commonly used interventions in the treatment of chronic venous insufficiency. It is performed with minimal analgesic use, tolerable postprocedural pain, and prompt return to activities of daily living. Typical complications, though rare, include failure of total venous occlusion, deep venous thrombosis, skin hyperpigmentation, infection, and skin burn. Here, we report the case of a patient who developed suppurative thrombophlebitis with methicillin-resistant Staphylococcus aureus bacteremia, requiring surgical resection.

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Section: Discussionmentioning

confidence: 87%

Surgical resection for suppurative thrombophlebitis of the great saphenous vein after radiofrequency ablation

Grady

Aizpuru

Farley

et al. 2019

Journal of Vascular Surgery Cases, Innovations and Techniques

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“…[1][2][3][4] Thrombophlebitis Without Varicose Veins Thrombophlebitis migrans is observed when a short segment of vein (often in the arm) becomes phlebitic and is associated with the presence of tumors (eg, mucin-secreting carcinoma) involving the body and tail of the pancreas, stomach, lung, breast, and colon. It usually follows minor trauma to a superficial varicose vein resulting in localized superficial aseptic thrombosis causing a hard, palpable cord along the line of the affected vein.…”

Section: Introductionmentioning

confidence: 99%

Superficial Thrombophlebitis of the Legs: A Randomized, Controlled, Follow-up Study

Nicolaides¹,

Errichi²,

Cesarone³

et al. 1999

Angiology

123

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The aim of the present study was to evaluate the effects of different treatment plans (compression only, early surgery, low-dose subcutaneous heparin [LDSH], low-molecular-weight heparin [LMWH], and oral anticoagulant [OC] treatment) in the management of superficial thrombophlebitis (STP), by considering efficacy and costs in a 6-month, randomized, follow-up trial. Patients with STP, with large varicose veins without any suspected/documented systemic disorder, were included. Criteria for inclusion were as follows: presence of varicose veins; venous incompetence (by duplex); a tender, indurated cord along a superficial vein; and redness and heat in the affected area. All patients were ambulatory. Exclusion criteria were obesity, cardiovascular or neoplastic diseases, bone/joint disease, problems requiring immobilization, and age > 70 years. Patients with superficial thrombophlebitis without varicose veins and patients under treatment with drugs at referral were also excluded. Color duplex (CD) was used to detect concomitant deep vein thrombosis (DVT) and to evaluate the extension or reduction of STP at 3 and 6 months. Venography was not used. Of 562 patients included, 3.5% had had a recent DVT in the same limb affected by SVT and 2.1% in the contralateral limb. In six patients DVT was present in both limbs. These patients were treated with anticoagulants and excluded from the follow-up. After 3 and 6 months the incidence of STP extension was higher in the elastic compression and in the saphenous ligation groups (p < 0.05). There was no significant difference in DVT incidence at 3 months among the treatment groups. Stripping of the affected veins was associated with the lowest incidence of thrombus extension. The cost for compression alone was the lowest and the cost including LMWH was the highest. The average cost was 1,383 US$. However the highest social cost (lost working days, inactivity) was observed in subjects treated only with stockings.

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“…Suppurative or septic thrombophlebitis refers to a condition characterized by venous wall inflammation and thrombosis associated with prolonged bacteraemia, and is usually encountered in patients with defined underlying conditions such as the presence of an intravascular device, burns, and malignancy (Fowler et al, 2015;Fry et al, 1994;Gillespie et al, 2000;Hammond et al, 1988;Mermel et al, 2009;Phua et al, 2019;Pruitt et al, 1970). The term 'septic thrombosis' has been adopted recently to describe intravascular device-related Staphylococcus aureus bacteraemia, likely sustained by secondary thrombus contamination (Wilson Dib et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…The term 'septic thrombosis' has been adopted recently to describe intravascular device-related Staphylococcus aureus bacteraemia, likely sustained by secondary thrombus contamination (Wilson Dib et al, 2018). In older series, bacteraemia associated with thrombus infection has been described as a life-threatening disease, with a reported incidence in critical care settings of 4% and an attributable mortality of approximately 80% (Hammond et al, 1988;Pruitt et al, 1970).…”

Section: Introductionmentioning

confidence: 99%

“…Principles of treatment in septic thrombophlebitis are not well defined and include source control (such as removal of the intravascular device and/or surgical debridement), appropriate antimicrobial chemotherapy, and anticoagulation (Andes et al, 1998;Baker et al, 1979;Fowler et al, 2015;Hammond et al, 1988). Moreover, with the exception of a very old series (Pruitt et al, 1970), no data are presently available in the literature on Gramnegative bacteraemic septic thrombosis (GN-ST).…”

Section: Introductionmentioning

confidence: 99%

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Gram-negative septic thrombosis in critically ill patients: A retrospective case–control study

Spaziante

Giuliano

Ceccarelli

et al. 2020

International Journal of Infectious Diseases

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Background: Data on septic thrombosis caused by Gram-negative bacilli (GN-ST) in intensive care unit (ICU) patients are currently limited. Methods: The aim of this retrospective case-control study (matched 1:3) performed over a 15-month period on ICU patients with bacteraemia, associated (cases) or not (controls) with GN-ST, was to assess 30-day mortality and clinical/microbiological features of GN-ST. Results: During the study period, 16 patients with GN-ST and 48 controls were analyzed. Polytrauma was the cause of ICU admission in 12 (75%) cases and 22 (46%) controls (p = 0.019). In no case of septic thrombosis was surgical debridement performed. The site of venous thrombosis was more frequently in the lower limbs, associated with bone fracture in nine out of 12 (75%) cases. The median duration of bacteraemia (22 days vs 1 day; p < 0.001) and time to clinical improvement (15 days vs 4 days; p < 0.001) were significantly longer in cases than in controls. On analysis of the receiver operating characteristics (ROC) curve, bacteraemia >72 h was significantly associated with GN-ST (area under the curve (AUC) 0.95, sensitivity 0.996 and specificity 0.810; p < 0.001). Finally, 30-day mortality was 20% in cases and 67% in controls (p < 0.001). Conclusions: Critically ill patients with GN-ST showed specific clinical features. Despite delayed bacteraemia clearance, targeted antibiotic therapy plus anticoagulation usually provided clinical improvement and a low 30-day mortality rate.

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Suppurative Thrombophlebitis: A New Look at a Continuing Problem

Cited by 9 publications

References 0 publications

Surgical resection for suppurative thrombophlebitis of the great saphenous vein after radiofrequency ablation

Surgical resection for suppurative thrombophlebitis of the great saphenous vein after radiofrequency ablation

Superficial Thrombophlebitis of the Legs: A Randomized, Controlled, Follow-up Study

Gram-negative septic thrombosis in critically ill patients: A retrospective case–control study

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