Suppressor T cells activated by lymphoblastoid cell lines inhibit pokeweed mitogen-lnduced immunoglobulin synthesis

Tsukuda, Koji; Tsukuda, Yasuko; Klein, George

doi:10.1016/0008-8749(81)90259-8

Cited by 13 publications

(4 citation statements)

References 27 publications

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“…Little or no suppressive activity was evident when supernatants from Daudi or NALM-1 were used. In contrast, a recent report [29] indicates that K562 does not inhibit the induction of immunoglobulin synthesis of B lymphocytes by pokeweed mitogen. The findings are discussed in the context of the immunosuppression associated with cancer and the apparent selective inhibition of different lymphocyte functions by material elaborated by different neoplasms.…”

mentioning

confidence: 63%

Suppressor substance produced by the K562 cell line in vitro

Korzelius

Bealmear

Holtermann

1983

Journal of Surgical Oncology

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Supernatant fluids from three human cultured cell lines, K562, NALM-1, and Daudi, all isolated from patients with lymphoreticular malignancies, were tested for suppressive activity toward normal lymphocytes in vitro. It was found that the K562 line elaborated material which effectively suppressed the response of normal human blood lymphocytes to the T-cell mitogens phytohemagglutinin and concanaval in A as well as the mixed lymphocyte reaction. Little or no suppressive activity was evident when supernatants from Daudi or NALM-1 were used. In contrast, a recent report [29] indicates that K562 does not inhibit the induction of immunoglobulin synthesis of B lymphocytes by pokeweed mitogen. The findings are discussed in the context of the immunosuppression associated with cancer and the apparent selective inhibition of different lymphocyte functions by material elaborated by different neoplasms.

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confidence: 63%

Suppressor substance produced by the K562 cell line in vitro

Korzelius

Bealmear

Holtermann

1983

Journal of Surgical Oncology

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“…In this regard, there have been numerous reports of an immunoregulatory function(s) associated with B-cell subpopulations. These include activities associated with antigen presentation, production of anti-idiotypic antibodies, and, more recently, suppressor cell activity (5,6,9,10,15,17,18,23,42). Such cellular interactions could ultimately result in direct suppression via a B-suppressor cell or the induction of other immunoregulatory pathways involving T-suppressor cells.…”

Section: Infect Immunmentioning

confidence: 99%

Immune suppression induced by Actinobacillus actinomycetemcomitans: effects on immunoglobulin production by human B cells

1990

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Actinobacillus actinomycetemcomitans produces an immunosuppressive factor (ISF) which has been shown to suppress mitogen- and antigen-induced DNA, RNA, and protein synthesis in human T lymphocytes. In this study, we examined purified A. actinomycetemcomitans ISF for its ability to alter immunoglobulin production by human B cells. The ISF caused a dose-dependent inhibition of pokeweed mitogen (PWM)-induced immunoglobulin G (IgG) and IgM production. Preexposure to ISF was not required to achieve maximal inhibition of immunoglobulin synthesis, as previously observed for its effect on T-cell activation. Nevertheless, the ISF appeared to act by irreversibly affecting the early stages of cell activation. While PWM-induced immunoglobulin production is under the influence of T-regulatory circuits, it appears that the ISF interacts directly with B cells. First, ISF failed to alter either the synthesis of interleukin-2 (IL-2) or the expression of IL-2 receptors on T cells. Second, experiments in which individual purified populations of cells were exposed to ISF, washed, and placed back into tissue culture indicated that when all cells (i.e., T cells, B cells, and monocytes) were exposed to ISF, significant suppression was observed. However, when only one cell population was treated with ISF, suppression of both IgG and IgM synthesis was observed only when the B-cell-enriched population was exposed to ISF. These results in conjunction with our earlier findings suggest that the ISF functions via the activation of a regulatory subpopulation of B lymphocytes, which in turn either directly or indirectly (via suppressor T cells) downregulate both B- and T-cell responsiveness. Furthermore, it is hypothesized that patients who harbor A. actinomycetemcomitans could suffer from local or systemic immune suppression. This suppression may enhance the pathogenicity of A. actinomycetemcomitans itself or that of some other opportunistic organism.

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“…Monolayer-protected metal clusters (MPCs) bridge the gap between small molecules and complexes containing only a few metal atoms and larger, metallic nanoparticles composed of thousands of metal atoms. MPCs typically contain several tens to a few hundred metal atoms . Among MPCs, thiolate- and phosphine-protected gold clusters have been given the most attention, because of their exceptional stability in solution.…”

Section: Introductionmentioning

confidence: 99%

Second-Order Nonlinear Optical Scattering Properties of Phosphine-Protected Au₂₀ Clusters

Knoppe

Zhang

Wan

et al. 2016

Ind. Eng. Chem. Res.

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We report the first hyperpolarizability of the [Au20(PP3)4]Cl4 cluster (PP3: tris(2-(diphenylphosphino)ethyl)phosphine) using the Hyper-Rayleigh Scattering technique. This is the first determination of nonlinear optical properties of a phosphine-protected “superatomic” gold cluster. Weak contributions of multiphoton-excited fluorescence were observed in the spectral dispersion of the generated light upon excitation at 1300 and 1064 nm. The first hyperpolarizability of the intrinsically chiral cluster is weaker than that of thiolate-protected gold clusters of similar size and inherent chirality.

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Suppressor T cells activated by lymphoblastoid cell lines inhibit pokeweed mitogen-lnduced immunoglobulin synthesis

Cited by 13 publications

References 27 publications

Suppressor substance produced by the K562 cell line in vitro

Suppressor substance produced by the K562 cell line in vitro

Immune suppression induced by Actinobacillus actinomycetemcomitans: effects on immunoglobulin production by human B cells

Second-Order Nonlinear Optical Scattering Properties of Phosphine-Protected Au₂₀ Clusters

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Suppressor T cells activated by lymphoblastoid cell lines inhibit pokeweed mitogen-lnduced immunoglobulin synthesis

Cited by 13 publications

References 27 publications

Suppressor substance produced by the K562 cell line in vitro

Suppressor substance produced by the K562 cell line in vitro

Immune suppression induced by Actinobacillus actinomycetemcomitans: effects on immunoglobulin production by human B cells

Second-Order Nonlinear Optical Scattering Properties of Phosphine-Protected Au20 Clusters

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Second-Order Nonlinear Optical Scattering Properties of Phosphine-Protected Au₂₀ Clusters