Suppressor of Cytokine Signaling 3 Inhibits Breast Tumor Kinase Activation of STAT3

Abstract

Background: Expression of breast tumor kinase (Brk) is linked to breast carcinoma. Results: SOCS3 binds to Brk and inhibits its ability to tyrosine phosphorylate STAT3. Conclusion: To date SOCS3 is the only negative modulator described for Brk, and it may play a significant role as a tumor suppressor. Significance: Understanding the mechanism by which SOCS3 inhibits Brk provides knowledge to silence its action in tumor progression.

HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion

“…33 Furthermore, other E3 ligases, namely CHIP (C terminus of Hsc70-interacting protein) and SOCS3 (suppressor of cytokine signaling 3) were recently reported to enhance the proteasomal degradation of PTK6. 34,35 These data add further support to our finding that PTK6 levels are regulated by the proteasome and the regulation of E3 ligases in hypoxia warrants further investigation. This study also demonstrates that hypoxic PTK6 has a role in regulating cellular invasion and migration (Fig.…”

LncRNA‐ENST00000501520 promotes the proliferation of malignant‐transformed BEAS‐2B cells induced with coal tar pitch mediated by target genes

“…On one hand, SOCS3 could inhibit tumor growth, migration, and invasion in hepatocellular carcinoma . And it was also reported as a cancer suppressor in head and neck squamous cell carcinoma, breast cancer . On the other hand, SOCS3 plays a tumor‐promoting role in some kinds of cancers.…”

Tracing the footprints of the breast cancer oncogene BRK — Past till present

“…in breast carcinoma [96]. An increase in BRK kinase activity has also 558 been demonstrated in HaCat cells in response to calcium and ionomycin its association with the latter via the SH2 domain [97]. SOCS3 was 567 shown to primarily enhance the degradation of BRK, an event mediated 568 mainly by the kinase inhibitory region (KIR) of SOC3 [97] (Fig.…”