Abstract:The DNA structure checkpoint protein Rad26 ATRIP is also required for an interphase microtubule damage response. This checkpoint delays spindle pole body separation and entry into mitosis following treatment of cells with microtubule poisons. This checkpoint requires cytoplasmic Rad26 ATRIP , which is compromised by the rad26:4A allele that inhibits cytoplasmic accumulation of Rad26 ATRIP following microtubule damage. The rad26::4a allele also disrupts minichromosome stability and cellular morphology, suggesti… Show more
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