Suppressive effects of volatile anesthetics on cytokine release in human peripheral blood mononuclear cells

Mitsuhata, H; Shimizu, R; Yokoyama, Mineyuki

doi:10.1016/0192-0561(95)00026-x

Cited by 123 publications

(77 citation statements)

References 16 publications

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“…That this effect has clinical relevance is suggested by the following lines of evidence. First, this anti-inflammatory effect of the volatile anesthetics sevoflurane, isoflurane and desflurane was also demonstrated in animal models of inflammation (6,18,34) and with human cells from healthy donors (35). Second, the inhibitory properties on the IκB· degradation and inducing properties on IκB· protein content occurred at concentrations comparable to those used during sevoflurane or isoflurane inhalation in clinical practice (36).…”

Section: Discussionmentioning

confidence: 99%

Sevoflurane and isoflurane decrease TNF-α-induced gene expression in human monocytic THP-1 cells: Potential role of intracellular IκBα regulation

Boost

Leipold²,

Scheiermann³

et al. 2009

Int J Mol Med

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Abstract. The nuclear factor (NF)-κB/inhibitory (I)κB· pathway is one of the most important intracellular signal transduction pathways during inflammation which is induced by a variety of major early response cytokines. Recent studies suggest that volatile anesthetics interfere with inflammatory cytokine production through inhibition of intracellular signal transduction pathways. We, therefore, aimed to investigate the effects of the volatile anesthetics sevoflurane and isoflurane on NF-κB/IκB·-dependent intracellular signal transduction in human monocytic THP-1 cells induced by tumor necrosis factor-· (TNF-·) and production of interleukin-8 (IL-8) and downstream heme oxygenase-1 (HO-1). THP-1 cells, a human monocytic cell line, were used in an in vitro model which enables the exposure to volatile anesthetics. Using this model, THP-1 cells were subjected to sevoflurane or isoflurane exposure (1 MAC each) and were stimulated with TNF-· (50 or 100 ng/ml). Compared to untreated cells, expression of intracellular HO-1-protein and release of IL-8 into cell culture supernatants and corresponding mRNA expression were attenuated in THP-1 cells exposed to sevoflurane and isoflurane, respectively. Moreover, translocation of NF-κB and degradation of IκB· were markedly reduced by both anesthetics. Notably, under unstimulated conditions, exposure to sevoflurane induced a sustained upregulation of the IκB· content in THP-1 cells. We demonstrated inhibition of TNF-·-induced gene expression and release of IL-8 and HO-1 in human monocytic THP-1 cells exposed to both volatile anesthetics. This was associated with an upregulated intracellular IκB· content followed by decreased NF-κB translocation. This was more sustained during exposure to sevoflurane and may provide an additional intracellular mechanism for the anti-inflammatory effects associated with sevoflurane administration.

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Section: Discussionmentioning

confidence: 99%

Sevoflurane and isoflurane decrease TNF-α-induced gene expression in human monocytic THP-1 cells: Potential role of intracellular IκBα regulation

Boost

Leipold²,

Scheiermann³

et al. 2009

Int J Mol Med

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“…Moreover, inhaled anesthetics had a negative effect on cytotoxicity of natural killer cells and NK-like cells, indicated by altered cytokine release (17). Besides these, sevoflurane was shown to suppress antitumor immunity through inhibiting the release of cytokine such as IL-1B\TNF-α from NK cells in vitro (18,19). On the contrary，the effects of propofol on NK cell immune function was different from volatile anesthetic.…”

mentioning

confidence: 98%

Effects of Sevoflurane or Propofol on Immune Function in Patients Undergoing Hepatectomy

Gao¹,

Song²,

Zhang³

et al. 2017

J Anesth Perioper Med

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“…Various studies have shown immunosuppressive effects of volatile anesthetics on peripheral blood mononuclear cell (PBMCs) proliferation and cytokine release (23)(24)(25). Ferrero and coworkers, in vitro, demonstrated impaired lymphocyte capping of surface immunoglobulins and concanavalin A receptors on human PBMCs one hour after exposure to halothane I% in oxygen (23).…”

Section: Volatile Anestheticsmentioning

confidence: 99%

Immunological Modifications Induced from Products Used during the Perioperative Period

Cardinale

Mastrototaro

Cappiello

et al. 2011

Int J Immunopathol Pharmacol

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Anesthetics and other products used during the perioperative period may influence immune function not only merely by reducing the HPA-axis stress response but also by directly modulating innate and adaptive immune responses. Most of the literature on the immune effects of anesthetics has been derived from in vitro or animal studies, due to the number of confounding variables in “real life” surgical settings. These immunosuppressive effects might not normally have clinical consequences for an immune-competent patient, but may act as important modifiers in postoperative morbidity and mortality. Furthermore, some inhibitory effects on neutrophil functions may provide a therapeutically beneficial effect under specific surgical clinical conditions, such as ischemia-reperfusion injury.

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Suppressive effects of volatile anesthetics on cytokine release in human peripheral blood mononuclear cells

Cited by 123 publications

References 16 publications

Sevoflurane and isoflurane decrease TNF-α-induced gene expression in human monocytic THP-1 cells: Potential role of intracellular IκBα regulation

Sevoflurane and isoflurane decrease TNF-α-induced gene expression in human monocytic THP-1 cells: Potential role of intracellular IκBα regulation

Effects of Sevoflurane or Propofol on Immune Function in Patients Undergoing Hepatectomy

Immunological Modifications Induced from Products Used during the Perioperative Period

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