Suppressive effects of Vochysia divergens aqueous leaf extract and its 5-methoxyflavone on murine macrophages and lymphocytes

Abstract

Our findings showed that the aqueous leaf extract of V. divergens and its flavonoid reduced the production of excessive pro-inflammatory markers, collaborating with the Pantanal folk medicinal tradition that recommends the tea of cambará leaves for both asthma and flu. In addition, this study contributes to the knowledge of the pharmacological properties of 5-methoxy flavones, a poorly investigated subclass of flavonoids.

Immunomodulatory potential of flavonoids for the treatment of autoimmune diseases and tumour

“…A wealth of evidence suggested that flavonoids had a regulatory function on mice macrophages in vitro/vivo 59,60 . Remarkably, the effect of flavonoids is independent from their different structure (Table 1).…”

“…However, more and more studies showed that flavonoids inhibited the activation and maturation of macrophages. For example, flavonoid 1 extracted from Vochysia divergens could inhibit NO levels of LPS‐stimulated murine macrophages by downregulating iNOS expression 60 . Several other flavonoids isolated from Platycladus orientalis and Murraya paniculate also showed an inhibiting effect on the expression of NO, IL‐6 and TNF‐α of murine macrophages in vitro 63,64 .…”