Suppressive effects of resveratrol on epithelial-mesenchymal transition in the YKG1 glioblastoma cell-line

Pektaş, Mehmet Bilgehan; Aslan, Esra; Fırat, Fatma; Karaca, Çiğdem; Güzel, Hilal; Yıldızhan, Serhat

doi:10.5455/medscience.2021.05.154

Cited by 1 publication

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“…Res, which has a role in the defense mechanism of plants against fungicides, has been found to have many different properties in experimental studies (Bohara et al, 2022). In a cell culture study, Res was found to suppress the epithelial-mesenchymal transition in the YKG1 glioblastoma cell line (Pektas et al, 2021). Its protective efficacy against spinal cord ischemiareperfusion injury has been demonstrated in rats .…”

Section: Introductionmentioning

confidence: 99%

Protective effects of resveratrol on permethrin-induced fetotoxicity in rats

YÜKSEL¹,

ASLAN

Tosun

et al. 2023

Anatolian Journal of Botany

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Synthetic pyrethroid insecticides have been widely used for years to be protected from the harmful effects of insects and control disease vectors. In this study, the potential effects of resveratrol, a polyphenolic compound, against the potential toxicity of permethrin, an effective pyrethroid derivative, on the fetus were investigated. In the study, Wistar female rats were divided into four groups Control, Sham, Permethrin, and Permethrin + Resveratrol. The lung, liver, kidney, and small intestine development of fetuses were evaluated histopathologically. Also, Bone Morphogenetic Protein 4 (BMP-4) in bone tissue development and Fibroblast Growth Factor-1 (FGF-1) expressions in the lung were examined immunohistochemically. All structures in the control and sham groups were normal. Permethrin caused epithelial damage, regression in bronchial and primitive alveolar development in the lung; congestion, edema, and sinusoidal dilatation around the central vein in the liver; tubular epithelial degeneration, regression in glomeruli and tubule formation in the kidney; epithelial degeneration and irregularity in the villus structure in the small intestine. Immunohistochemical results indicated that permethrin administration decreased BMP-4 levels in bone tissue and FGF-1 levels in the lung. After resveratrol application was found to greatly alleviate histopathological and immunohistopathological variability in all tissues. Oral consumption of permethrin by pregnant rats caused growth retardation and tissue damage in many different tissues in offspring. Intake of resveratrol during pregnancy showed protective effects against fetotoxicity caused by permethrin.

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Section: Introductionmentioning

confidence: 99%