Suppressive effects of germinated buckwheat on development of fatty liver in mice fed with high-fat diet

Choi, In-Wook; Seog, Ho-Moon; Park, Yongkon; Kim, Y.; Choi, Hyo‐Kyoung

doi:10.1016/j.phymed.2007.05.002

Cited by 27 publications

(19 citation statements)

References 17 publications

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“…High reduction in body gain was recorded with G. max after 4, 11 and 17 weeks (1.5±1.6), (3.48±1.26) and (4.39±1.4) compared to the control (HFD) group. This finding agrees with many authors as (Han et al, 2002;Park et al, 2005Choi et al, 2007;Bose et al, 2008). They found that plant extracts greatly reduced body weight in dose dependent manner in high fat fed mice.…”

Section: Effect Of the Extracts On Body Weightsupporting

confidence: 93%

“…Although there is small difference in food intake in control group and treated groups but no significant difference between all groups. This means that the high fat diet only or high fat diet + plant extract did not affect on the mice appetite as well as the energy intake for long term consumption and these results agree with (Park et al, 2005;Choi et al, 2007;Bruno et al, 2008;Ramgobal et al, 2010;Chandrasekaran et al, 2012).…”

Section: Food Intakesupporting

confidence: 84%

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Effect of methanol extracts of three dietary plants growing in Egypt on mice fed with high fat diet

2014

j app pharm sci

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The objective of the present investigation was to evaluate the preventive effect of methanol extracts of three dietary plants growing in Egypt; Cassia fistula (Family Fabaceae), Cynara scolymus (Family Asteraceae) and Glycine max (Family fabaceae) on body weight gain, hepatic and kidney index, food intake, lipid profile and serum enzymes in mice fed high fat diet during different periods 4, 11 and 17 weeks. For this purpose, the mice were divided into groups of eight mice each group as follows; normal group, high fat diet (HFD) group , HFD + methanol extract of C. fistula group, HFD + Methanol extract of C. scolymus group and HFD + methanol extract of G. max group, the dose of plant extract in each treated group was 100 mg /Kg body weight. After 4 weeks to 17 weeks the body weight, the relative liver weight, lipid profile and serum enzymes increased in the control group (HFD) compared to the normal. Treatment with each plant plant extract led to reduction in body weight and improvement of lipid and serum enzymes of the treated mice compared to the control groups. Extract of G.max showed the highest activity. These results were supported by hepatic histology examination which showed improvement of fatty liver tissue.

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Section: Effect Of the Extracts On Body Weightsupporting

confidence: 93%

Section: Food Intakesupporting

confidence: 84%

Effect of methanol extracts of three dietary plants growing in Egypt on mice fed with high fat diet

2014

j app pharm sci

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“…Toll-like receptors (TLRs) are a family of molecules that are involved in the innate immunity. In obese adipocytes, the expression of several TLRs is elevated and activation of these receptors is thought to produce chemotactic signals, such as MCP-1, which provoke macrophage infiltration [ 47 , 48 ]. Activated macrophages in adipose tissue secrete pro-inflammatory cytokines, which leads to chronic low-grade inflammation in obesity [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response

et al. 2017

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Tartary buckwheat (Fagopyrum tataricum) has been established globally as a nutritionally important food item, particularly owing to high levels of bioactive compounds such as rutin. This study investigated the effect of tartary buckwheat extracts (TBEs) on adipogenesis and inflammatory response in 3T3-L1 cells. TBEs inhibited lipid accumulation, triglyceride content, and glycerol-3-phosphate dehydrogenase (GPDH) activity during adipocyte differentiation of 3T3 L1 cells. The mRNA levels of genes involved in fatty acid synthesis, such as peroxisome proliferator-activated receptor-γ (PPAR-γ), CCAAT/enhancer binding protein-α (CEBP-α), adipocyte protein 2 (aP2), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and stearoylcoenzyme A desaturase-1 (SCD-1), were suppressed by TBEs. They also reduced the mRNA levels of inflammatory mediators such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), and inducible nitric oxide synthase (iNOS). In addition, TBEs were decreased nitric oxide (NO) production. These results suggest that TBEs may inhibit adipogenesis and inflammatory response; therefore, they seem to be beneficial as a food ingredient to prevent obesity-associated inflammation.

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“…The addition of polyphenol fractions of Salix matsudana leaves to the diet decreases body weight gain, plasma triacylglycerol levels, and hepatic steatosis in male Wistar rats [76]. Choi et al [85] showed that the oral administration of germinated buckwheat caused significant reduction in body weight, serum parameters, and hepatic steatosis in male C57BL/6 mice. Chan et al [74] indicated that the consumption of tea catechin showed a reduction in body weight, serum parameters, and hepatic lipid levels in hamsters.…”

Section: In Vivomentioning

confidence: 99%

Phenolic compounds: Evidence for inhibitory effects against obesity and their underlying molecular signaling mechanisms

Hsu

Yen²

2008

Molecular Nutrition Food Res

176

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Phenolic compounds are widely present in the plant kingdom. Many epidemiological studies have indicated that consumption of some plant-derived foodstuffs with high phenolic content is associated with the prevention of some diseases and that these compounds may have similar properties to antioxidants, antimutagenic agents, antithrombotic agents, anti-inflammatory agents, anti-HIV-1, and anticancer agents. However, obesity is an important topic in the world of public health and preventive medicine. Relationships between body mass index, waist circumference, or waist-to-hip ratio and the risk of development of some diseases (such as heart disease, dyslipidemia, hypertension, non-alcoholic fatty liver disease, diabetes, kidney failure, cancer, stroke, osteoarthritis, and sleep apnea) have been observed. Evidence that phenolic compounds have beneficial effects in fighting obesity is increasingly being reported in the scientific literature. These in vitro and in vivo effects of phenolic compounds on the induction of pre-adipocytic and adipocytic apoptosis and inhibition of adipocytic lipid accumulation are considered in detail here. This review presents evidence of their inhibitory effects on obesity and their underlying molecular signaling mechanisms.

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Suppressive effects of germinated buckwheat on development of fatty liver in mice fed with high-fat diet

Cited by 27 publications

References 17 publications

Effect of methanol extracts of three dietary plants growing in Egypt on mice fed with high fat diet

Effect of methanol extracts of three dietary plants growing in Egypt on mice fed with high fat diet

The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response

Phenolic compounds: Evidence for inhibitory effects against obesity and their underlying molecular signaling mechanisms

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