Suppressive Effects by Leaves of the<i>Dypsis lutescens</i>Palm on Fat Accumulation in 3T3-L1 Cells and Fat Absorption in Mice

Koyama, Tomoyuki; Miyata, Mitsuyoshi; Nishimura, Takashi; Yazawa, Kazunaga

doi:10.1271/bbb.110574

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…in DMSO) or pure compounds (10, 20 μg/mL, soln. in DMSO) [63]. The control group was cultured in the basic maintenance medium without P. sibiricus extracts, fractions or pure compounds.…”

Section: Methodsmentioning

confidence: 99%

Khellactone Derivatives and Other Phenolics of Phlojodicarpus sibiricus (Apiaceae): HPLC-DAD-ESI-QQQ-MS/MS and HPLC-UV Profile, and Antiobesity Potential of Dihydrosamidin

et al. 2019

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With obesity, the consumption of phenolic-enriched food additives as a part of traditional nutrition avoids the negative implications of eating high-calorie products. This study investigated the new herbal food additive, Phlojodicarpus sibiricus roots and herb, ubiquitously used in Siberia as a spice. Chromatographic techniques such as HPLC-DAD-ESI-QQQ-MS/MS and microcolumn HPLC-UV were the basic instruments for component profiling and quantification, and antiobesity potential was investigated using a differentiated 3T3-L1 adipocytes assay. We found that the roots and herb of P. sibiricus were high-coumarin-containing additives inhibiting triacylglycerol accumulation in 3T3-L1 preadipocytes. Forty-one phenolics were detected in P. sibiricus extracts, and 35 were coumarins, including 27 khellactone derivatives present as esters and glucosides. Total coumarin content varied from 36.16 mg/g of herb to 98.24 mg/g of roots, and from 0.32 mg/mL to 52.91 mg/mL in P. sibiricus preparations. Moreover, Siberian populations of P. sibiricus were characterised by a different HPLC-based coumarin profile. The most pronounced inhibiting effect on triacylglycerol accumulation in 3T3-L1 preadipocytes was shown for dihydrosamidin (khellactone 3′-O-isovaleroyl-4′-O-acetyl ester), which was more active than other khellactone esters and glucosides. The results demonstrated that if used as a food additive Phlojodicarpus sibiricus could be a source of bioactive coumarins of the khellactone group with high antiobesity potential.

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“…in DMSO) or pure compounds (10, 20 μg/mL, soln. in DMSO) [63]. The control group was cultured in the basic maintenance medium without P. sibiricus extracts, fractions or pure compounds.…”

Section: Methodsmentioning

confidence: 99%

Khellactone Derivatives and Other Phenolics of Phlojodicarpus sibiricus (Apiaceae): HPLC-DAD-ESI-QQQ-MS/MS and HPLC-UV Profile, and Antiobesity Potential of Dihydrosamidin

et al. 2019

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“…The constituent Isovitexin which has the source from Dypsis lutescens possesses anticancer activity. The leaf extract of the same plant exhibited a suppressive effect on fat accumulation in 3T3-L1 cells and fat absorption in mice (Koyama et al, 2012). The antioxidant and anti-inflammatory properties of D. lutescens help in maintaining liver health and functions (El-Ghonemy et al, 2019).…”

Section: Description Of the Study Speciesmentioning

confidence: 99%

EVALUATION OF In-vitro ANTIBACTERIAL ACTIVITY AGAINST GRAM-NEGATIVE BACTERIA USING SILVER NANOPARTICLES SYNTHESIZED FROM Dypsis lutescens LEAF EXTRACT

Akshaya

Aravind

Kumar

et al. 2022

J. Chil. Chem. Soc.

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Recent advances in nanotechnology and the synthesis of nanoparticles through biosynthesis have increased the urge in scientists than for chemical or physical methods. The biosynthesis method is the most significant method than a conventional method because of its eco-friendly, low cost and rapid synthesizing process. The present study describes the antibacterial activity of silver nanoparticles (AgNPs) synthesized from leaf extracts of Dypsis lutescens. The synthesis of AgNPs was confirmed by colour change from light yellow to brown colour. Further, the morphology of the biosynthesized nanoparticles, average size and presence of functional groups were characterized by UV -Visible spectroscopy (UV-Vis), X-Ray diffraction (XRD) and Fourier transform infrared spectroscopy, respectively. The UV spectra results show a strong resonance center and surface of silver nanoparticles at 450 nm. XRD studies revealed that the synthesized AgNPs show crystalline in shape. The FT-IR spectrum described the biological molecules which stabilize and form the silver nanoparticles in the aqueous medium. The average AgNPs size was found to be 31 nm by using the Debye-Scherrer formula. The antimicrobial property of AgNPs was tested against Escherichia coli (MTCC 443) and Vibrio cholerae (MTCC 3906) pathogen, which showed maximum zones of inhibition of 22 mm at a concentration of 100 µL. Therefore, the biosynthesized AgNPs proved to have significant antibacterial activity.

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“…The methanol extract of Dypsis lutescens leaves, also known as bamboo palm, showed specific in vitro inhibitory activity towards pancreatic lipase and lowered triglyceride accumulation in 3T3-L1 pre-adipocytes [205].…”

Section: From Leavesmentioning

confidence: 99%

Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research

Castro¹,

Preto²,

Vasconcelos³

et al. 2016

CTMC

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Obesity is a global health threat. OECD reported that more than half (52%) of the adult population in the European Union is overweight or obese. Obesity and obesity-related co-morbidities have deep negative effects on morbidity, mortality, professional and personal quality of life. Healthcare costs represent a negative impact of this disease, with an associated economic cost of 100 billion US$ per year in the United States. The most prescribed drugs for obesity treatment worldwide are orlistat, and phentermine/topiramate extended release, while the major prescribed drug for the same disease in the US are exenatide and dapagliflozin. The so far developed drugs, targeting weight loss, have a long history of malignant secondary effects. There is still a lack of efficient and safe drugs to treat obesity and related metabolic complications since in many cases cure cannot be reached by bariatric surgery or healthy lifestyle habits. Terrestrial and aquatic organisms are a promising source of valuable, bioactive compounds, often with interest for human health. Some of the natural compounds or organisms have been used for centuries by humans as traditional medicine foods. In this review, we give insights into the adipose tissue function and development, and the progress in traditional anti-obesity pharmacotherapy. A major focus is to highlight the state of the art of natural compounds with anti-obesity properties and their potential as candidates for drug development; an overview is given about natural compounds derived from different marine animal sources, cyanobacteria, marine phytoplankton, fungus or plants.

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Suppressive Effects by Leaves of theDypsis lutescensPalm on Fat Accumulation in 3T3-L1 Cells and Fat Absorption in Mice

Cited by 4 publications

References 17 publications

Khellactone Derivatives and Other Phenolics of Phlojodicarpus sibiricus (Apiaceae): HPLC-DAD-ESI-QQQ-MS/MS and HPLC-UV Profile, and Antiobesity Potential of Dihydrosamidin

Khellactone Derivatives and Other Phenolics of Phlojodicarpus sibiricus (Apiaceae): HPLC-DAD-ESI-QQQ-MS/MS and HPLC-UV Profile, and Antiobesity Potential of Dihydrosamidin

EVALUATION OF In-vitro ANTIBACTERIAL ACTIVITY AGAINST GRAM-NEGATIVE BACTERIA USING SILVER NANOPARTICLES SYNTHESIZED FROM Dypsis lutescens LEAF EXTRACT

Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research

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