Abstract:Inflammasome is activated when pattern recognition receptor (PRR) senses danger signals such as Calreticulin (CALR) from damaged\dying cells leading to secretion of Interleukin-1β (IL-1β). High levels of CALR mediated invasive breast cancer (BC) phenotype. The NOD-like receptor (NLR) family Pyrin domain-containing protein3 (NLRP3) inflammasome showed various tumor promoting effects in BC. Interestingly, IL-1β led to endocrine resistance in Estrogen receptor positive (ER+) BC patients and enhanced production of… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.