Suppressive Effect of Peach Leaf Extract on Glucose Absorption from the Small Intestine of Mice

Shirosaki, Miyuki; Koyama, Tomoyuki; Yazawa, Kazunaga

doi:10.1271/bbb.110541

Cited by 8 publications

(6 citation statements)

References 29 publications

(28 reference statements)

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“…15) Our previous report described the suppressive effect of peach leaf extract on glucose absorption in glucose-loaded mice. 5) In the present study, PLE significantly suppressed postprandial elevation of the blood glucose level in mice (Fig. 1).…”

Section: Discussionsupporting

confidence: 66%

“…4) Our previous report showed that peach leaf extract had anti-hyperglycemic activity in carbohydrateloaded mice. 5) Furthermore, the extract suppressed postprandial elevation of the blood glucose level through the inhibition of glucose absorption in the small intestine in mice. However, the active principle in the crude extract of peach leaf has not yet been identified.…”

mentioning

confidence: 97%

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Peach Leaf Contains Multiflorin A as a Potent Inhibitor of Glucose Absorption in the Small Intestine in Mice

Shirosaki

Gotö²,

Hirooka³

et al. 2012

Biological & Pharmaceutical Bulletin

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Peach leaf extract has anti-hyperglycemic effects on the postprandial blood glucose level in glucoseloaded mice. In our previous study, the mechanism of action was considered to be the inhibition of glucose absorption in the small intestine. To elucidate the active principle in peach leaf, purification of the active compound and a structure determination were performed. With the use of bioassay-guided fractionation using glucose-loaded mice, the acetylated kaempferol glycoside multiflorin A (MFA), a potent inhibitor of glucose absorption from the intestine, was isolated from the MeOH extract of leaf of the edible peach Prunus persica. The structure was identified by HPLC using thiazolizine derivatives and by an analysis of its spectral data. The inhibitory effect of MFA against glucose absorption was demonstrated in the dose dependent manner in mice. However, as the deacetylated analog of MFA, multiflorin B did not show the activity at the in vivo, the activity of MFA was suggested to depend on the acetyl group on the sugar moiety. This is the first report of anti-hyperglycemic activity of MFA in peach leaf extract. MFA may be useful in functional foods or medicines for preventing the postprandial absorption of glucose in hyperglycemia.

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Section: Discussionsupporting

confidence: 66%

mentioning

confidence: 97%

Peach Leaf Contains Multiflorin A as a Potent Inhibitor of Glucose Absorption in the Small Intestine in Mice

Shirosaki

Gotö²,

Hirooka³

et al. 2012

Biological & Pharmaceutical Bulletin

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“…It was shown that various plant compounds inhibit the SGLT transporters, and even grapefruit extracts are proven to inhibit SGLT1. Typically the flavonoids and their glucosides like quercetin glucosides are made responsible for this effect. − This might also contribute to the prevailed increasing effect of GFJ on SBWC, as the effect of fructose is overweighed due to inhibition of glucose and water uptake.…”

Section: Discussionmentioning

confidence: 99%

Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects

et al. 2018

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Grapefruit juice (GFJ) is known to affect the bioavailability of drugs in different ways. Despite the influence on gastrointestinal enzymes and transporters, the influence on gastrointestinal fluid kinetics is regarded to be relevant for the absorption of several drugs. Thus, it was the aim of this pilot study to investigate the gastric and intestinal volumes after intake of GFJ compared to isocaloric fructose and glucose solutions and water. The gastric and small intestinal volume kinetics after intake of 240 mL of GFJ, 10.6% fructose solution, 10.6% glucose solution, and water were investigated with magnetic resonance imaging in a four-way crossover study in six healthy human volunteers. The carbohydrate content of the administered beverages was quantified by high-performance liquid chromatography. Even with the small sample size of this pilot study, the gastric emptying of GFJ and the glucose solution was significantly slower than that of water. The fructose solution had only a slightly delayed gastric emptying. Small bowel water content was increased by administration of GFJ and fructose solution, whereas it was decreased by glucose compared to the administration of pure water. At 80 min the small bowel water content after GFJ was twice as high as the small bowel water content after administration of water. The observed influence of GFJ on gastrointestinal fluid kinetics may explain certain phenomena in drugs pharmacokinetics. The effect is double edged, as the slower gastric emptying and increased intestinal filling can lead to enhanced or altered absorption. Due to the comparability of fruit juices, a general effect of fruit juices on gastrointestinal volumes is likely.

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“…Mul A can significantly inhibit intestinal glucose uptake in glucose-loaded mice, thereby significantly reducing the postprandial blood glucose peak and maintaining its stability in mice [ 7 ]. This is associated with intestinal barrier function rather than changes in glucose metabolism [ 24 ]. In addition, Mul A possesses aromatase inhibitory activity with an IC 50 of 15.5 μM [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the chemical proﬁle from four germplasms sources of Pruni Semen using UHPLC-LTQ-Orbitrap-MS and multivariate analyses

Zhao

Liu²,

Zhang³

et al. 2022

Journal of Pharmaceutical Analysis

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Suppressive Effect of Peach Leaf Extract on Glucose Absorption from the Small Intestine of Mice

Cited by 8 publications

References 29 publications

Peach Leaf Contains Multiflorin A as a Potent Inhibitor of Glucose Absorption in the Small Intestine in Mice

Peach Leaf Contains Multiflorin A as a Potent Inhibitor of Glucose Absorption in the Small Intestine in Mice

Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects

Evaluation of the chemical proﬁle from four germplasms sources of Pruni Semen using UHPLC-LTQ-Orbitrap-MS and multivariate analyses

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