Suppressive Effect of Dietary Fucoidan on Proinflammatory Immune Response and MMP-1 Expression in UVB-Irradiated Mouse Skin

Lee

et al. 2018

Preprint

Marine algae have been considered as abundant source of bioactive compounds with cosmeceutical potential. Recently, a great deal of interest has focused on the health-promoting effects of marine bioactive compounds. Carbohydrate is a major and abundant constitute of marine algae that have been utilized in cosmetic formulations, such as moisturizing and thickening agents. In addition, marine carbohydrates have been suggested as promising bioactive biomaterials for various skin beneficial properties, such as anti-oxidant, anti-melanogenic and anti-skin aging. Therefore, marine algae carbohydrates have potential of skin health benefits for value-added cosmeceutical application. The present review focused on the various biological capacities and potential skin health benefits of bioactive marine carbohydrates.

Section: Anti-skin Aging Activitymentioning

confidence: 99%

Beneficial Effects of Marine Algae-Derived Carbohydrates for Skin Health

Lee

et al. 2018

Preprint

“…Because the LMF treatment was mostly absorbed before the irradiation, the results seemed to be involved in photo-protective effects rather than UV filtering effects. Although only one in vivo study has demonstrated the anti-photoaging effects of native fucoidan via oral administration [17], this is the first study to show that LMF ameliorates UBV-induced photoaging via topical application.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, unlike native fucoidan with a high molecular-weight of approximately 20,000 kDa, low molecular-weight fucoidan (LMF)—less than 10 kDa—has shown more biological activities because of its high absorption and bioavailability [13]. However, a few studies have examined the anti-photoaging effect of fucoidans, which include three in vitro studies demonstrating the down-regulating effects on MMP-1 [14,15,16] and one in vivo study showing inhibitory effects on inflammation and MMP-1 expression following oral administration [17]. We previously showed that topical application of LMF has dermal wound healing effects with anti-inflammatory and antioxidant activities and modulates ECM rebuilding factors, such as transforming growth factor (TGF)-β1, fibroblast growth factor (FGF)-2, and MMPs [18].…”

Section: Introductionmentioning

confidence: 99%

Anti-Photoaging Effects of Low Molecular-Weight Fucoidan on Ultraviolet B-Irradiated Mice

Song

et al. 2018

Marine Drugs

Ultraviolet (UV) B exposure induces DNA damage and production of reactive oxygen species (ROS), which causes skin photoaging through signaling pathways of inflammation and modulation of extracellular matrix remodeling proteins, collagens, and matrix metalloproteinase (MMP). As low molecular-weight fucoidan (LMF) has potential antioxidant and anti-inflammatory properties, we examined the protective effects of LMF against UVB-induced photoaging. A UVB-irradiated mouse model was topically treated with myricetin or LMF at 2.0, 1.0 and 0.2 mg/cm2 (LMF2.0, LMF1.0 and LMF0.2, respectively) once a day for 15 weeks. Wrinkle formation, inflammation, oxidative stress, MMP expression, and apoptosis in the treated regions were compared with those in a distilled water-treated photoaging model (UVB control). LMF treatments, particularly LMF2.0 and LMF1.0, significantly inhibited the wrinkle formation, skin edema, and neutrophil recruitment into the photo-damaged lesions, compared with those in the UVB control. While LMF decreased interleukin (IL)-1β release, it increased IL-10. The LMF treatment inhibited the oxidative stresses (malondialdehyde and superoxide anion) and enhanced endogenous antioxidants (glutathione). Additionally, LMF reduced the mRNA expression of MMP-1, 9, and 13. The histopathological analyses revealed the anti-photoaging effects of LMF exerted via its antioxidant, anti-apoptotic, and MMP-9-inhibiting effects. These suggest that LMF can be used as a skin-protective remedy for photoaging.

“…CC is a brown algae species belonging to the genus Costaria and the family Costariaceae, distributed across the sea of Korea, China, and Japan [16]. Although recent studies have established several biological activities of various marine algae [17, 18], only a few studies have reported the biological effects of CC in cancer and CCL4-induced liver injury [19, 20]. In our previous study, CC extract suppressed the production of proinflammatory cytokines and Th2 cytokines in HaCaT cells, and primary splenocytes and histamine in MC/9 cells [21].…”

Section: Introductionmentioning

confidence: 99%

<b><i>Costaria costata</i></b> Extract Suppresses Development of Atopic Dermatitis in chloro-2,4-dinitrobenzene-treated NC/Nga Mice

Kim¹,

Lee²,

Kwon³

et al. 2018

Skin Pharmacol Physiol

We investigated the potential effects of Costaria costata (CC) on atopic dermatitis (AD) development in chloro-2,4-dinitrobenzene (DNCB)-treated NC/Nga mice. CC is a brown alga distributed across the seas of Korea, China, and Japan. A total of 40 mice were randomly assigned to 5 groups with 8 mice per group: untreated Balb/c mice, AD control (0.1% w/v DNCB-treated NC/Nga mice), positive control (i.e., DNCB-treated NC/Nga mice fed a dietary supplement of 66.6 mg/kg of body weight [b.w.] of CJLP133), DNCB-treated NC/Nga mice fed a dietary supplement of 100 mg/kg b.w. of CCE10 (CCE10 100), and DNCB-treated mice fed a dietary supplement of 300 mg/kg b.w. of CCE10 (CCE10 300) groups. The CCE10 100 and CCE10 300 treatment groups suppressed AD development including clinical and histopathological changes and a reduction in skin hydration induced by DNCB. In addition, Th2 cytokine production in primary splenocytes, serum IgE and histamine production, and mast cell infiltration into the skin were suppressed in the CCE10 300 mice compared to the CCE10 100 mice. Our finding demonstrated an inhibitory effect of CCE10 in AD development by means of improving the Th1/Th2 cytokine balance and anti-inflammatory effect in an in vivo model.