The optimal conditions for the synthesis of lauroyl er ythorbate through the condensation of er ythorbic acid with lauric acid using immobilized lipase in organic solvents were determined, which are as follows: 0.5 mmol of erythorbic acid, 3.75 mmol of lauric acid, 5 mL of acetonitrile, 50 mg of Chirazyme ® L-2 C2, 60℃. Octanoic, decanoic, myristic, and palmitic acid were also used for the synthesis of acyl erythorbate; however, the effect of the acyl chain length of the fatty acid on the reaction conversion was not observed. The DPPH radical scavenging activities of erythorbic acid and acyl erythorbates were measured and it was indicated there was no difference in the activity between erythorbic acid and acyl erythorbates in ethanol solution. Additionally, the suppressive ability of acyl er ythorbate against lipid oxidation was investigated. Palmitoyl er ythorbate significantly improved the oxidative stability of methyl linoleate to the same extent as that of palmitoyl ascorbate. Based on these results, acyl er ythorbate could be considered to be a useful food additive as an amphiphilic antioxidant in a food system such as lipid microcapsules.