Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats

R, Cui; He, Jiaqing; Wang, Bao-en; Zhang, Fu-Kui; Chen, Guangyong; Yin, Shanshan; Shen, Hong

doi:10.1007/s00280-002-0532-5

Cited by 86 publications

(63 citation statements)

References 36 publications

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“…Expression of growth factor receptorbound protein 2 and Raf 1, and son of sevenless was inhibited by those treatments, respectively [2931] . Herbal compound 861, a formula composed of herbs with dissolving stasis and nourishing Qi efficacy, prevents 2acetylaminofluorene (2AAF) induced hepatocarcinogenesis in rats [32] . A new antitumor formula with tonifying Qi, soothing liver and dissolving stasis effects inhibits hepatocarcinogenesis induced by HBV and AFB1 accompanied by superoxide dismutase (SOD) and glutathione Stransferase (GST) activation and decreased malondialdehyde (MDA) [33] .…”

Section: Stasis-dissolving and Other Herbal Formulasmentioning

confidence: 99%

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Wang

2015

WJH

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and other TCM syndromes (Zheng). Modern treatments such as surgery, transarterial chemoembolization (TACE) and high intensity focus ultrasound treatment would influence the manifestation of TCM syndromes. Herbs with traditional efficacy of tonifying Qi, blood and Yin, soothing liver-Qi stagnation, clearing heat and detoxifying and dissolving stasis, have been demonstrated to be potent to prevent hepatocarcinogenesis. TCM has been widely used in all aspects of integrative therapy in hepatocarcinoma, including surgical resection, liver transplantation, TACE, local ablative therapies and even as monotherapy for middle-advanced stage hepatocarcinoma. Clinical practices have confirmed that TCM is effective to alleviate clinical symptoms, improve quality of life and immune function, prevent recurrence and metastasis, delay tumor progression, and prolong survival time in hepatocarcinoma patients. The effective mechanism of TCM against hepatocarcinoma is related to inducing apoptosis, autophagy, anoikis and cell senescence, arresting cell cycle, regulating immune function, inhibiting metastasis and angiogenesis, reversing drug resistance and enhancing effects of chemotherapy. Along with the progress of research in this field, TCM will contribute more to the prevention and treatment of hepatocarcinoma. AbstractTraditional Chinese medicine (TCM) has played a positive role in the management of hepatocarcinoma. Hepatocarcinoma patients may present Qi-stagnation, damp-heat, blood stasis, Qi-deficiency, Yin-deficiency REVIEWSubmit a

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Section: Stasis-dissolving and Other Herbal Formulasmentioning

confidence: 99%

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Wang

2015

WJH

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“…Moreover, it has been reported that herbal formulations containing Radix Astragali and some of its constituents could produce hepatoprotective, 2 antiviral 3 and antioxidative effects. 4 Recently, evidence from various animal and clinical studies has demonstrated that Radix Astragali may possess anticarcinogenic property, 5 which could attenuate the systemic side effects of conventional antineoplatic drugs. 6 Nonsteroidal anti-inflammatory drug (NSAID)-activated gene (NAG-1) is a novel therapeutic target which contributes to the antitumorigenic and proapoptotic effects in various cancer cells.…”

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confidence: 99%

A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID‐activated gene

Auyeung

Cho

2009

Intl Journal of Cancer

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Astragalus membranaceus has been used to ameliorate the side effects of antineoplastic drugs because of its immunomodulating nature. We had recently demonstrated that total Astragalus saponins (AST) possess anticarcinogenic and proapoptotic properties in human colon cancer cells and tumor xenograft. In this study, we identified NSAID-activated gene (NAG-1) as a potential molecular target of AST. The growth-inhibitory and proapoptotic effects of AST were assessed in a panel of human cancer cell lines. Hoechst 33342 nuclear staining, Annexin V-FITC/propidium iodide staining, Western immunoblotting, real-time PCR, luciferase reporter assay and electrophoretic mobility shift assay were conducted to determine the association of NAG-1 and related transcription factors with AST during its regulation of apoptotic activities. Moreover, the combined proapoptotic and NAG-1 promoting activities of AST and/or inhibitors of the PI3K-Akt pathway were also examined. AST caused overexpression of NAG-1, leading to PARP cleavage and apoptosis. The induction of NAG-1 promoter activity by the drug was associated with increased gene expression, in addition to prior increase in Egr-1 expression and DNA binding activity. AST-induced NAG-1 activation was intensified when PI3K inhibitor LY294002 or Akt inhibitor was cotreated and reversed by NAG-1 siRNA transfection. Nevertheless, the extent of NAG-1 induction could not be altered by the ERK inhibitor PD98059. Our results indicate that NAG-1 is a potential molecular target of AST in its antitumorigenic and proapoptotic actions, which would have additive effects when used along with PI3K-Akt inhibitors. The information obtained could facilitate future development of a novel target-specific chemotherapeutic agent with known molecular pathway. ' 2009 UICC

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“…Astragalosides, a type of triterpenoid saponin, are substances with phytochemical and pharmacological properties. Triterpenoid saponins are major active ingredients (Wang et al, 2002;Bedir et al, 2000;Cui et al, 2003;Kwon and Park, 2012) and are characterized by a four or five ring configuration consisting of 30 carbons with several oxygens attached. They are assembled from a C 5 isoprene unit through the cytosolic mevalonate pathway to make a C 30 compound, and they are steroidal in nature.…”

Section: Introductionmentioning

confidence: 99%

Variation of Astragalosides Contents in Cultivated Astragalus membranaceus

Kim¹,

Jun²,

Lim³

et al. 2012

Korean Journal of Medicinal Crop Science

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: This study was conducted to determine the contents of astragalosides in Astragalus membranaceus. The total astragaloside content (1701 ㎍ g -1 ) of 2 year-cultivated astragalus was the highest among the variously cultivated astragalus plants. Upon an increase in cultivation time, the average value of the total astragaloside content decreased (from 1650 ㎍ g -1 to 645 ㎍ g -1 ). Especially, the content of astragaloside decreased rapidly. Comparison between the top and subterranean parts of harvested astragalus plants showed that as the cultivation time increased, the astragaloside content of the top part decreased. On the other hand, the subterranean part demonstrated the opposite pattern. The astragaloside content of the top root increased compared to that in the lateral root (from 1.9 ㎍ g -1 to 33.4 ㎍ g -1 ). Further, the content of astragaloside increased in the top root as the cultivation time increased.

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Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats

Cited by 86 publications

References 36 publications

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID‐activated gene

Variation of Astragalosides Contents in Cultivated Astragalus membranaceus

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