Suppressive Effect of Astaxanthin Isolated from the<i>Xanthophyllomyces dendrorhous</i>Mutant on Ethanol-Induced Gastric Mucosal Injury in Rats

Kim, Jeong Hwan; Choi, Seok Keun; Choi, Seo‐Hyun; Kim, Han Kyeom; Chang, Hyo Ihl

doi:10.1271/bbb.69.1300

Cited by 41 publications

(35 citation statements)

References 20 publications

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Section: Protecting Against Ethanol and Drug Toxicitiesmentioning

confidence: 99%

“…Kim et al [47] found that the oral administration of astaxanthin had significant protection against ethanol-induced gastric lesion in rats and could inhibit elevation of the lipid peroxide level in gastric mucosa. The histologic examination clearly indicated that the acute gastric mucosal lesion induced by ethanol nearly disappeared after pretreatment with astaxanthin [47]. Kamath et al [46] compared the antioxidant and anti-ulcer potency of esterified astaxanthins, saponified astaxanthin, and total carotenoid from the microalga H. pluvialis in ethanol-induced gastric ulcers in rats, and showed that total carotenoids and astaxanthin esters, especially esterified astaxanthin exerted a dosedependent gastroprotective effect on acute, ethanol-induced gastric lesions in rats.…”

Section: Protecting Against Ethanol and Drug Toxicitiesmentioning

confidence: 99%

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Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Yuan

Peng

Yin

et al. 2010

Molecular Nutrition Food Res

544

309

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The ketocarotenoid astaxanthin can be found in the microalgae Haematococcus pluvialis, Chlorella zofingiensis, and Chlorococcum sp., and the red yeast Phaffia rhodozyma. The microalga H. pluvialis has the highest capacity to accumulate astaxanthin up to 4-5% of cell dry weight. Astaxanthin has been attributed with extraordinary potential for protecting the organism against a wide range of diseases, and has considerable potential and promising applications in human health. Numerous studies have shown that astaxanthin has potential health-promoting effects in the prevention and treatment of various diseases, such as cancers, chronic inflammatory diseases, metabolic syndrome, diabetes, diabetic nephropathy, cardiovascular diseases, gastrointestinal diseases, liver diseases, neurodegenerative diseases, eye diseases, skin diseases, exercise-induced fatigue, male infertility, and HgCl₂-induced acute renal failure. In this article, the currently available scientific literature regarding the most significant activities of astaxanthin is reviewed.

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Section: Protecting Against Ethanol and Drug Toxicitiesmentioning

confidence: 99%

Section: Protecting Against Ethanol and Drug Toxicitiesmentioning

confidence: 99%

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Yuan

Peng

Yin

et al. 2010

Molecular Nutrition Food Res

544

309

View full text Add to dashboard Cite

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“…Indomethacin, a widely-used non-steroidal anti-inflammatory drug, inhibits both COX isoforms and thereby exacerbates damage to gastric tissues (Delaney et al 2007;Maity et al 2009). Lastly, alcohol induces gastric lesions, in part by inhibition of anti-oxidant enzymesleading to induction of oxidative stress, modulation of the NO system and reduction of gastric mucosal blood flow (Kim et al 2005;Arafa & Sayed-Ahmed 2003).…”

Section: Introductionmentioning

confidence: 99%

Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats

Sokar

Elsayad

Ali

2016

Journal of Immunotoxicology

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Research in the treatment of gastric ulcer has involved the investigation of new alternatives, such as anti-depressant drugs. The present study was designed to investigate the gastroprotective effects of fluoxetine against indomethacin and alcohol induced gastric ulcers in rats and the potential mechanisms of that effect. Fluoxetine (20 mg/kg) was administered IP for 14 days. For comparative purposes, other rats were treated with ranitidine (30 mg/kg). Thereafter, after 24 h of fasting, INDO (100 mg/kg) or absolute alcohol (5 ml/kg) was administered to all rats (saline was administered to naïve controls) and rats in each group were sacrificed 5 h (for INDO rats) or 1 h (for alcohol rats) later. Macroscopic examination revealed that both fluoxetine and ranitidine decreased ulcer scores in variable ratios, which was supported by microscopic histopathological examination. Biochemical analysis of fluoxetine-or ranitidine-pre-treated host tissues demonstrated reductions in tumor necrosis factor (TNF)-and myeloperoxidase (MPO) levels and concomitant increases in gastric pH, nitric oxide (NO) and reduced glutathione (GSH) contents. Fluoxetine, more than ranitidine, also resulted in serotonin and histamine levels nearest to control values. Moreover, immuno-histochemical analysis showed that fluoxetine markedly enhanced expression of cyclooxygenases COX-1 and COX-2 in both models; in comparison, ranitidine did not affect COX-1 expression in either ulcer model but caused moderate increases in COX-2 expression in INDOinduced hosts and high expression in alcohol-induced hosts. The results here indicated fluoxetine exhibited better gastroprotective effects than ranitidine and this could be due to anti-secretory, anti-oxidant, anti-inflammatory and anti-histaminic effects of the drug, as well as a stabilization of gastric serotonin levels. ARTICLE HISTORY

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Section: 3)mentioning

confidence: 99%

“…[6][7][8] The antioxidant activity of astaxanthin has been reported to be approximately 10 times stronger than that of other carotenoids tested, including zeaxanthin, lutein, canthaxanthin, and -carotene, and 100 times greater than that of -tocopherol. [9][10][11] Hence, astaxanthin has attracted commercial interest not only as a pigmentation source but also as a potent antioxidative reagent.…”

Section: 3)mentioning

confidence: 99%

High-Level Production of Astaxanthin byXanthophyllomyces dendrorhousMutant JH1 Using Statistical Experimental Designs

Kim¹,

Kang²,

Kim³

et al. 2005

Bioscience, Biotechnology, and Biochemistry

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Medium composition was optimized for high-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs. Glucose and yeast extract were the most important factors affecting astaxanthin production. Glucose 3.89%, yeast extract 0.29%, KH 2 PO 4 0.25%, MgSO 4 0.05%, MnSO 4 0.02%, and CaCl 2 0.01% were optimum for high-level production of astaxanthin. Under optimized conditions, the maximum concentration of astaxanthin obtained after 7 d of cultivation was 36.06 mg/l. The concentration of astaxanthin predicted by a polynomial model was 36.16 mg/l. Key words: astaxanthin; carotenoids; high-level production; statistical experimental designs; Xanthophyllomyces dendrorhousAs lipid-soluble pigments, carotenoids constitute a wide range of natural pigments, and they are employed in the agrochemical industry as a food and feed additive. Among them, astaxanthin (3,3 0 -dihydroxy-,-carotene-4,4 0 -dione) is the principal carotenoid in marine animals such as crustaceans and salmonoids. 1) Astaxanthin gives attractive pigmentation to many farmed animals and contributes to consumer appeal in the marketplace. To obtain a natural red-pink color, the use of astaxanthin for pigmentation in aquaculture, especially as a feed supplement in farmed salmon and trout, is necessary, since animals lack the ability to synthesize it de novo. 2,3)Astaxanthin also has important metabolic functions in animals, including conversion to vitamin A, 4) enhancement of immune response, 5) and protection against diseases such as cancer by scavenging oxygen radicals. [6][7][8] The antioxidant activity of astaxanthin has been reported to be approximately 10 times stronger than that of other carotenoids tested, including zeaxanthin, lutein, canthaxanthin, and -carotene, and 100 times greater than that of -tocopherol.9-11) Hence, astaxanthin has attracted commercial interest not only as a pigmentation source but also as a potent antioxidative reagent. A recent FDA communication admitted the use of astaxanthin as a supplement and listed it for use in salmonoid fish feed.Various natural biological sources of astaxanthin, including the crustacea and crustacean extracts, the green microalga Haematococcus pluvialis, and the red yeast Xanthophyllomyces dendrorhous, have been reported.12-14) Among them, H. pluvialis and X. dendrorhous are currently considered to be sources of astaxanthin for industrial production, because crustacean meals have relatively low contents of astaxanthin and high levels of moisture, ash, and chitin. H. pluvialis has high concentrations of astaxanthin, but industrial application is limited by lengthy autotrophic cultivation in open freshwater ponds and the necessity of disrupting the cell wall to liberate the carotenoid. X. dendrorhous has desirable properties and potential commercial value as a dietary source of natural astaxanthin, including rapid heterotrophic metabolism and production of high cell densities in bioreactors.The cost of astaxanthin production is one of the main factors...

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Suppressive Effect of Astaxanthin Isolated from theXanthophyllomyces dendrorhousMutant on Ethanol-Induced Gastric Mucosal Injury in Rats

Cited by 41 publications

References 20 publications

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats

High-Level Production of Astaxanthin byXanthophyllomyces dendrorhousMutant JH1 Using Statistical Experimental Designs

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