Suppressive Effect of Antibiotic Siomycin on Antibody Production

Abstract

The antibiotic thiazole compound siomycin, which we have found from the culture broth of Actinomycetes (strain No.806097) in search of antibody production inhibitor, showed the in vitro immunosuppressive property against B-cells stimulated with T-cell independent antigen DNP-LPS (dinitrophenyl-lipopolysaccharide) while it also showed inhibitory effect against Tcell proliferation. Its inhibitory mechanism was considered to be different from that of FK506, the representative of T-cell immunosuppressant. Moreover, siomycin showed inhibitory effect in both T-cell dependent and independent murine antibody production models and decreased the severity in murine collagen arthritis model. Therefore, siomycin is a unique immunosuppressant which has potential for the treatment of some antibody-mediated diseases.

Effect of the inosine 5′-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection

“…In contrast, results show no in vivo suppression of anti-DNP antibody production by FK506 and cyclosporine A. Our results complete a previous in vitro study reporting the insufficient inhibitory potency of FK506 on DNP-LPS-stimulated B cells [29]. Suzuki et al also reported no antibody suppression by both FK506 and cyclosporine A in human B cell cultures in the absence of T cells [30].…”

A Fluorescent Probe for the 70 S‐Ribosomal GTPase‐Associated Center

“…[7][8][9][10] Beyond its ensuing strong antibacterial activity on Gram-positive organisms, [4,7] 1 has also been reported to display potency against the malaria parasite [11] and selected tumor cell lines, [12,13] and to have immunosuppressant properties. [14] Here we describe a fluorescent high-affinity probe derived from 1 that allows the interaction of thiopeptides with their target to be quantified.…”

Fortschritte in der Chemie und Biologie natürlicher Antibiotika

“…[51] Sie wirkt, ähnlich wie viele andere Thiopeptid-Antibiotika, durch Binden an die 23S-Region der bakteriellen ribosomalen RNA und an das Protein L11, wodurch die GTPase-abhängige Funktion der ribosomalen 50S-RNA gestört und die Proteinbiosynthese unterbunden wird. [52] Der Biosyntheseweg zu Thiostrepton wurde intensiv untersucht, und der mutmaßliche Reaktionsweg über eine Diels-Alder-Reaktion [46b] inspirierte die Gruppe von Nicolaou [53] bei ihren Versuchen, den Dehydropiperidinkern des Moleküls aufzubauen.…”