Suppression of tumor necrosis factor-alpha-induced neutrophil adherence responses by essential oils

Abe, Shigeru; Maruyama, Naho; Hayama, Koremasa; Ishibashi, Hidetoshi; Inoue, Shigeharu; Oshima, Hiroki; Yamaguchi, Hideyo

doi:10.1080/09629350310001633342

Cited by 83 publications

(65 citation statements)

References 17 publications

(17 reference statements)

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“…In carrageenan paw oedema there was a dose-dependent effect of TEO in diet comparable to DTH reaction, but we did not detect any significant immunostimulatory effect at low concentrations. The observed anti-inflammatory effects of thyme essential oil could be correlated with its in vitro ability to manipulate neutrophil activation (Abe et al 2003). Furthermore, thyme essential oil shows anti-oxidant activity and has an inhibitory effect on lipid peroxidation, which could decrease the strength of inflammatory response in carrageenan paw oedema (Bozin et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Juhás¹,

Bujňáková²,

Rehák³

et al. 2008

Acta Vet. Brno

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Juhás Š., D. Bujňáková, P. Rehák, Š. Čikoš, S. Czikková, J. Veselá, G. Iľková, J. Koppel: Anti-Inflammatory Effects of Thyme Essential Oil in Mice. Acta Vet. Brno 2008, 77: 327-334. Plant essential oils are plant secondary metabolites possessing various pharmacological properties, primarily anti-oxidative, antimicrobial or immunomodulatory ones. The aim of this work was to study the effects of thyme essential oil dietary administration in murine DTH/ CHS reaction, carrageenan paw oedema and TNBS colitis. Thyme essential oil was added to the murine diet at three concentrations (5000, 2500 and 1250 ppm) and fed to Balb/c mice. The extent of ear swelling in DTH/CHS reaction and paw oedema induced by carrageenan application was measured using the Mitutoyo thickness gauge. In the model of TNBS colitis we evaluated the changes in body weight, the colon weight : body weight ratio, bacterial translocation to mesenteric lymph nodes, and macroscopical and histological scores. IL-1 and IL-6 messenger RNA expression in colonic samples of one experimental group were assessed using quantitative real-time reverse transcriptase PCR. Dietary supplementation with 5000 ppm of thyme essential oil significantly decreased paw oedema and ear swelling. This thyme essential oil concentration caused a significant inhibition of total mRNA IL-1 expression in the mouse colon, and markedly decreased the macroscopic and microscopic scores of colitis. On the other hand, the 1250 ppm of thyme essential oil in diet increased ear oedema induced by oxazolone application in mice. Our study indicates that thyme essential oil is able to affect murine experimental inflammatory models depending on the concentration used. It is concluded that the anti-inflammatory effects of thyme essential oil should be interpreted with a caution due to its contradictory, dose-related effects.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Juhás¹,

Bujňáková²,

Rehák³

et al. 2008

Acta Vet. Brno

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“…Lavender oil has shown strong antimutagenic activity, as oils from L. angustifolia exhibited a significant, concentration-dependent reduction in the mutagenic activity of TA98 bacterial strains exposed to the potent mutagen 2-nitrofluorene [39]. Although weak as compared to other essential oils, lavender oils exerted suppression of tumor necrosis factor alphainduced neutrophil adherence responses [40]. The antimutagenic properties of lavender make it a promising candidate for new applications in human healthcare, potentially as a topological application to protect skin cancer [39].…”

Section: Studies In Model Speciesmentioning

confidence: 99%

Biosynthesis and Therapeutic Properties ofLavandulaEssential Oil Constituents

Woronuk

Demissie²,

Rheault³

et al. 2010

Planta Med

170

117

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“…Previously, we reported that essential oils suppressed the LPS-and TNF-α-induced neutrophil adhesion at low concentrations, but not PMA-induced adhesion. 8) PMA activates protein kinase C in the cell membrane directly without the involvement of MAPK. These observations support the suggestion that rose water may suppress neutrophil activation perhaps through interactions with signal transduction via p38 MAPK.…”

Section: Fig 2 Inhibitory Effects Of Rose Oil and Its Constituents mentioning

confidence: 99%

“…Human peripheral blood neutrophils were obtained according to a modification of the method described previously by Abe et al 8) Heparinized venous blood obtained from healthy volunteers was mixed with 7% dextran solution and allowed to stand at room temperature for 1 h. The upper layer was collected to remove erythrocytes. The leukocyte-rich upper layer was centrifuged to collect the neutrophil-rich layer in Polymorphprep (Axis-shield PoC AS, Oslo, Norway), which was washed with RPMI1640 containing 10% FBS, and suspended in the same medium to a concentration of 4.0×10 6 cells/mL.…”

Section: Measurement Of the Neutrophil Adhesion Induced By Stimulantsmentioning

confidence: 99%

“…We reported previously that essential oils, such as geranium oil and lemongrass oil, suppressed neutrophil function 8) and inflammatory conditions, 9,10) and had anti-Candida effects. [11][12][13][14] As rose water contains small amounts of essential oil components, some of which are similar to the active components of geranium oil, rose water may suppress neutrophil function and have antimicrobial activity.…”

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confidence: 99%

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Inhibition of Neutrophil Adhesion and Antimicrobial Activity by Diluted Hydrosol Prepared from <i>Rosa damascena</i>

Maruyama

Tansho-Nagakawa

Miyazaki

et al. 2017

Biological & Pharmaceutical Bulletin

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Hydrosol prepared from the flowers of Rosa damascena (rose water) has been traditionally used for various health-related issues, including skin troubles such as erythema, itchiness, swelling. For the care of these skin troubles caused by microbial infection, both antimicrobial and antiinflammatory effects are required. Here, we investigated the effects of rose water on the growth of Candida albicans and methicillin-resistant Staphylococcus aureus (MRSA), which cause skin infections, and on the function of neutrophils, which play a major role in the regulation of inflammatory reactions. To assess its modulatory effects on neutrophils, the effects of rose water against neutrophil adhesion response were evaluated. Rose water inhibited mycelial growth of C. albicans at a concentration of ca. 2.2%, and reduced viability of MRSA within 1 h. Rose water suppressed neutrophil activation induced by lipopolysaccharide (LPS), tumor necrosis factor alpha (TNF-α), and N-formyl-Met-Leu-Phe (fMLP) at 5-15%. It also reduced the LPS-and TNF-α-induced cell surface expression of the adhesion-related molecule, cluster of differentiation (CD) 11b, but did not affect the migratory capacity of neutrophils with or without chemoattractant. These results suggest that rose water may reduce the pathogenicity of microbes, and attenuate neutrophil stimulation, which is involved in inflammatory responses. These findings suggest that rose water has a potential effect to inhibit skin inflammation caused by microbes.

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Suppression of tumor necrosis factor-alpha-induced neutrophil adherence responses by essential oils

Abstract: Thus, some essential oils used as antiinflammatory remedies suppress neutrophil activation by TNF-alpha at a low concentration (0.0125-0.025 %) in vitro.

Cited by 83 publications

References 17 publications

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Anti-Inflammatory Effects of Thyme Essential Oil in Mice

Biosynthesis and Therapeutic Properties ofLavandulaEssential Oil Constituents

Inhibition of Neutrophil Adhesion and Antimicrobial Activity by Diluted Hydrosol Prepared from <i>Rosa damascena</i>

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