Suppression of tumor cell invasiveness by hydrolyzable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity

Tanimura, Susumu; Kadomoto, Ryoji; Tanaka, Takashi; Zhang, Yingjun; Kouno, Isao; Kohno, Michiaki

doi:10.1016/j.bbrc.2005.03.116

Cited by 64 publications

(45 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been suggested as a potential crosslinking agent and improves the elastin and collagen stability in cardiovascular implants as evidenced by an increased resistance to proteolytic degradation against collagenase activity 5,6 . The inhibition of MMPs caused by plant polyphenolics was confirmed by gelatin zymography and observed for MMPs associated with various connective tissues 7,8 . Plant polyphenolics were tested for their ability to inhibit the prokaryotic and eukaryotic cell derived collagenase activity.…”

Section: Introductionmentioning

confidence: 69%

Studies on collagen-tannic acid-collagenase ternary system: Inhibition of collagenase against collagenolytic degradation of extracellular matrix component of collagen

Krishnamoorthy

Sehgal

Mandal

et al. 2011

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 69%

Studies on collagen-tannic acid-collagenase ternary system: Inhibition of collagenase against collagenolytic degradation of extracellular matrix component of collagen

Krishnamoorthy

Sehgal

Mandal

et al. 2011

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

“…Tannins have shown potential antiviral, antibacterial and antiparasitic effects (Akiyama et al, 2001;Lu et al, 2004). In the past few years tannins have also been studied for their potential effects against cancer through different mechanisms (Yang et al, 2000;Tanimura et al, 2005 oxidative substrate significantly delays or inhibit that substrate (Antolovich et al, 2002). It has been reported that the antioxidant activity of many compounds of botanical origin is proportional to antioxidant content suggesting a correlation between total phenolics and antioxidant activity (Rice-Evans et al, 1997;Veglioglu et al, 1998).…”

Section: Resultsmentioning

confidence: 99%

Polyphenolic Compounds and Free Radical Scavenging Activity in Eight Lamiaceae Herbs of Manipur

Khomdram

Singh

2011

Not Sci Biol

View full text Add to dashboard Cite

Eight plants of Lamiaceae under subfamily Nepetoideae found in Manipur, India were selected for estimation of their polyphenolic compounds and free radical scavenging activity which is expressed on dry weight basis. In this present study, the total phenol and flavonoid contents as well as the free radical scavenging activity were studied using spectrophotometric method. The total phenol content was determined based on Folin-Ciocalteau reagent, flavonoid was determined by aluminium chloride spectrophotometric method and tannin by Folin Dennis Method. The free radical scavenging activity was determined by using DPPH radical which is expressed as IC 50 (µg/ml). The total phenolic content varied from 21.39±0.927 to 46.28±0.543 mg/g, flavonoids content in the selected samples varied from 13.30±0.684 to 26.03±0.217 mg/g and tannin content varied from 8.72±0.160 to 17.04±0.206 mg/g. The free radical scavenging activity among the selected samples varied from 11.67±0.221 to 38.29±0.532 µg/ml. The correlation between the free radical scavenging activity with total phenol content (R 2 =0.511), with flavonoids (R 2 =0.241) and with tannin (R 2 =0.690) was calculated and maximum correlation value was found between tannin content and the free radical scavenging activity of the plant samples. The result supports that tannins were more responsible for free radical scavenging activity in the presently selected plants.

show abstract

“…Delphinidin inhibited cell migration [150], as well as hydrolyzable tannins, which also inhibited MMP-2 and -9 activities without suppressing the activation of ERK-MAPK or PI3K/AKT pathways [157]. EGCG prevented metastasis and invasion through its inhibitory effects on expression or activity of MMP [143,144,158,159] and focal adhesion kinase (FAK) and without affecting MT1-MMP and tissue inhibitor of MMP-2 (TIMP-2) [158,159].…”

Section: Inhibition Of Metastasismentioning

confidence: 99%

Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

Ramos¹

2008

Molecular Nutrition Food Res

621

499

View full text Add to dashboard Cite

Prevention of cancer through dietary intervention recently has received an increasing interest, and dietary polyphenols have become not only important potential chemopreventive, but also therapeutic, natural agents. Polyphenols have been reported to interfere at the initiation, promotion and progression of cancer. They might lead to the modulation of proteins in diverse pathways and require the integration of different signals for the final chemopreventive or therapeutic effect. Polyphenols have been demonstrated to act on multiple key elements in signal transduction pathways related to cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis and metastasis; however, these molecular mechanisms of action are not completely characterized and many features remain to be elucidated. The aim of this review is to provide insights into the molecular basis of potential chemopreventive and therapeutic activities of dietary polyphenols with emphasis in their ability to control intracellular signalling cascades considered as relevant targets in a cancer preventive approach.

show abstract

Suppression of tumor cell invasiveness by hydrolyzable tannins (plant polyphenols) via the inhibition of matrix metalloproteinase-2/-9 activity

Cited by 64 publications

References 18 publications

Studies on collagen-tannic acid-collagenase ternary system: Inhibition of collagenase against collagenolytic degradation of extracellular matrix component of collagen

Studies on collagen-tannic acid-collagenase ternary system: Inhibition of collagenase against collagenolytic degradation of extracellular matrix component of collagen

Polyphenolic Compounds and Free Radical Scavenging Activity in Eight Lamiaceae Herbs of Manipur

Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

Contact Info

Product

Resources

About