Suppression of TRIM8 by microRNA-182-5p restricts tumor necrosis factor-α-induced proliferation and migration of airway smooth muscle cells through inactivation of NF-Κb

Dang, Xiaomin; He, Beibei; Ning, Qian; Liu, Ya; Chang, Ying; Chen, Mingwei

doi:10.1016/j.intimp.2020.106475

Cited by 17 publications

(7 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TRIM8 is one of the TRIM family of proteins (also called as RBCC proteins), which are known to maintain a common structural feature of having a tripartite motif, distinguished by the presence of a RING domain (R), one or two B-boxes (B), and a coiled-coil domain (CC) [28]. Recent studies on TRIM8 strongly advocate for the critical role of TRIM8 as a regulator of cell proliferation [29] and as an important player in cancer [30], immunity [31], and in ammation [32]. Studies have shown that TRIM8 regulated cell cycle progression and mitosis by affecting cell cycle checkpoints and critical mitotic regulators and indirectly interacts with various motor microtubule-associated proteins (MAPs) such as kinesins [33].…”

Section: Discussionmentioning

confidence: 99%

The mutational burden in os odontoideum patients

Tian,

Gao,

Fan

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Os odontoideum(OO) is a rare bone malformation at the craniovertebral junction, the presence of which can lead to potential instability of atlantoaxial joints. The cause, prevalence and treatment of OO are still controversial. But the congenital factors are likely to be the main causes according to the current literature reports and the clinical characteristics of OO patients. To further explore the pathogenesis of OO, we conducted this study. Methods We consecutively recruited 25 OO patients from 2021 to 2023. The clinical manifestation and concomitant deformities were analyzed and whole-exome sequencing(WES) was performed. And the variants in OO patients were compared using genetic burden analysis with 79 normal population as controls. Results Combined with the P-value and OR value of the final data, CDC27(P = 0.002,OR = 5.08),FRG1BP(P = 0.004,OR = 5.59),TRIM8(P = 0.02,OR = 4.58) and CEP250(P = 0.005,OR = 7.78) were singled out as possible correlated gene with OO. Conclusion Our study firstly presented an exome-sequenced cohort and highlighted four novel rare variants associated with OO patients through genetic burden analysis. The results provided further evidence for potential oligogenic inheritance of OO.

show abstract

Section: Discussionmentioning

confidence: 99%

The mutational burden in os odontoideum patients

Tian,

Gao,

Fan

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The authors further demonstrated that circ_0002594 acts as a sponge for miR-139-5p to modulate the expression of tripartite motif 8 (TRIM8), which in turn stimulates cellular damage (Quan et al, 2022). Studies have also shown that miR-139-5p treatment and TRIM8 inhibition decreases ASMCs proliferation through inhibiting a chromatin remodeling factor BRG1, and inactivating NF-kb signaling pathway, respectively (Zhang et al, 2017;Dang et al, 2020). Another circRNA, circ_ 0000029 was found to regulate ASMC migration and proliferation by modulating miR-576-5p and KCNA1 expression (Wang R. et al, 2023).…”

Section: Circrnas and Airway Smooth Muscle Cells (Asmcs)mentioning

confidence: 96%

Circular RNAs: emerging players in asthma and COPD

Liu,

Ali,

Dua

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Circular RNAs (circRNAs) belong to a unique class of endogenously expressed non-protein-coding RNAs with a distinct circularized structure, characterized by the absence of 5′-cap and 3′-polyadenylate ends. They are generally formed through back-splicing from pre-mRNAs. They serve as regulators of transcription and splicing, and act as sponges for microRNAs (miRNAs) and RNA-binding proteins, thereby modulating the expression of target genes. As a result, they exert a substantial impact on a diverse array of cellular and biological processes, including cell proliferation, migration, inflammation, and oxidative stress. Asthma and COPD are chronic airway conditions that currently have no cure. In recent years, emerging evidence suggests that altered expression of circRNAs in airway, bronchial and immune cells is involved in asthma and COPD pathogenesis. Studies exploring circRNA dysregulation in asthma have showcased their involvement in regulating the proliferation, migration, and inflammation of airway smooth muscle and bronchial epithelial cells, as well as impacting goblet cell metaplasia, Th2 cell differentiation, and macrophage activation, primarily through interactions with miRNAs. Similarly, in COPD, circRNAs have shown altered expression patterns in the blood and lungs of patients, and these changes have been linked to modulating inflammation, oxidative stress, and airway remodeling in preclinical models. Furthermore, certain circRNAs have demonstrated promising potential as diagnostic and prognostic biomarkers for both asthma and COPD. This review delves into the current understanding of the function and molecular mechanisms of circRNAs in asthma and COPD, along with exploring their potential as biomarkers in these respiratory conditions.

show abstract

“…Recent studies on TRIM8 strongly advocate for the critical role of TRIM8 as a regulator of cell proliferation 9 , 12 and as an important player in cancer, 13 , 14 , 15 , 16 immunity, 17 and inflammation. 18 Here, the duality of TRIM8 has been reviewed in multiple contexts, like its function and cellular localization, and the emerging role of TRIM8 during the course of cell cycle and bipolar mitotic spindle formation has been discussed.…”

Section: Main Textmentioning

confidence: 99%

Rise of TRIM8: A Molecule of Duality

Bhaduri

Merla

2020

Molecular Therapy - Nucleic Acids

View full text Add to dashboard Cite

The human tripartite motif containing protein 8 (TRIM8), a member of TRIM family proteins, is known to play a dual role as both tumor suppressor and oncogene, and to function at the crosstalk of cancer and innate immunity. In this review, in addition to accumulating recent corroborations that endorse this dual character of TRIM8, we appraise the game-changing capacity of TRIM8 under stress conditions against the backdrop of cell proliferation, apoptosis, and cancer, and also highlight the duality of TRIM8 in multiple contexts like cellular localization, stress-induced conditions, and E3 ubiquitin ligase activity. Finally, we discuss the emerging role of TRIM8 during bipolar spindle formation and mitotic progression, and its growing sphere of influence across multiple human cancers and pathologies, and suggest TRIM8-linked axes that can be modulated further for anti-cancer therapeutics development.

show abstract

Suppression of TRIM8 by microRNA-182-5p restricts tumor necrosis factor-α-induced proliferation and migration of airway smooth muscle cells through inactivation of NF-Κb

Cited by 17 publications

References 50 publications

The mutational burden in os odontoideum patients

The mutational burden in os odontoideum patients

Circular RNAs: emerging players in asthma and COPD

Rise of TRIM8: A Molecule of Duality

Contact Info

Product

Resources

About