Abstract:24As an optically transparent model organism with an endothelial blood-brain barrier (BBB), 25 zebrafish offer a powerful tool to study the vertebrate BBB. However, the precise developmental 26 profile of functional zebrafish BBB acquisition and the subcellular and molecular mechanisms 27 governing the zebrafish BBB remain poorly characterized. Here we find a spatiotemporal gradient 28 of barrier acquisition. Moreover, we capture the dynamics of developmental BBB leakage using 29 live imaging, revealing a comb… Show more
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