Abstract:Leydig cells in fetal testes play crucial roles in masculinizing fetuses through androgen production. Gene knockout studies have revealed that growth factors are implicated in fetal Leydig cell (FLC) differentiation, but little is known about the mechanisms regulating this process. We investigated this issue by characterizing FLC progenitor cells using single-cell RNA sequencing. The sequence datasets suggested that thymosin β10 (Tmsb10) was transiently upregulated in the progenitors. While studying the functi… Show more
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