Suppression of the nociceptive jaw-opening reflex by stimulation of the red nucleus

Yajima, Eriko; Satoh, Yoshihide; Ishizuka, Kanako; Iwasaki, Shigeo; Terada, Kazuto

doi:10.1016/j.brainres.2012.07.053

Cited by 9 publications

(4 citation statements)

References 38 publications

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“…The Vo, the Vi and the Vc are relay stations which transmit somatosensory information from orofacial and tongue regions (Sessle, 2000;Waite, 2004). Our previous studies and other work suggest that the RN is involved in the control of somatic sensation from orofacial regions (Davis and Dostrovsky, 1986;Satoh et al, 2013;Yajima et al, 2012). Electrical stimulation of the lingual nerve strongly suppresses triggering and/or progression of the swallowing reflex (Zoungrana et al, 2000).…”

Section: Discussionmentioning

confidence: 95%

Suppression of the swallowing reflex by stimulation of the red nucleus

Satoh

Tsuji

Tsujimura

et al. 2015

Brain Research Bulletin

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Section: Discussionmentioning

confidence: 95%

Suppression of the swallowing reflex by stimulation of the red nucleus

Satoh

Tsuji

Tsujimura

et al. 2015

Brain Research Bulletin

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“…Its concomitant inhibitory influence on inspiratory activity suggests that this might be a site for respiratory-locomotor cycle coupling and for general coordination of locomotion and inspiratory activity (Bassal & Bianchi, 1982;Schmid et al, 1988). The red nucleus also modulates jaw opening and the low afferent and nociceptive jaw opening reflex (Satoh, Yajima, Ishizuka, Nagamine, & Iwasaki, 2013;Yajima, Satoh, Ishizuka, Iwasaki, & Terada, 2012). Thus, it might coordinate oromotor activity with breathing, according to the behavioural demands on the animal; for instance, by facilitating jaw opening during high activity to increase maximal airflow, hence ventilation.…”

Section: Perspectives and Functional Significancementioning

confidence: 99%

Retracted: Rubral modulation of breathing

Ghali

2019

Experimental Physiology

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Although normal triphasic eupnoea can be produced by the pontomedullary respiratory network after pontomesencephalic transection, the midbrain provides important modulation of respiration. Specifically, stimulation of the red nucleus elicits inspiratory inhibition, as manifest in the phrenic neurogram, in addition to excitation and inhibition of individual medullary respiratoryrelated units, with the majority of premotor units that receive rubral modulation being inhibited.Stimulation of the red nucleus also induces respiratory phase transitions, which appear to be pontine independent. These effects might be mediated by rubrobulbar and/or rubrospinal tracts.Although lesioning of the red nucleus does not alter respiration in normoxic conditions, it eliminates hypoxic ventilatory depression, which is the second phase of the biphasic ventilatory response to low oxygen tension. The finding that the red nucleus also plays a role in antinociception suggests that it might coordinate respiratory responses during noxious stimulation and, given that the red nucleus regulates upper limb flexors, it might represent one region in a distributed bulbar network contributing to respiratory-locomotor integration. Modulation of jaw opening by the red nucleus would support a model whereby it coordinates oromotor activity with breathing. Thus, the multiplicity of roles played by the red nucleus aptly position it to coordinate respiration in a variety of behavioural states. In this review, we seek to highlight the different features and regional specializations of the rubral contribution to respiratory control and underscore its vital importance to breathing in the freely behaving mammal. K E Y W O R D Sbreathing, chemosensitivity, hypoxic ventilatory depression, inspiratory off switch, locomotor, mesencephalic, midbrain, red nucleus

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“…Neuromodulation is a natural physiological process involving changes in neuronal and synaptic properties by neurons or substances released by neurons [27]. Non-invasive stimulation of the trigeminal nerve, as well as non-invasive stimulation of the vagus nerve, should also be considered scientifically validated non-invasive brain modulation techniques [28].…”

Section: Discussionmentioning

confidence: 99%

Application of Original Therapy for Stimulation of Oral Areas Innervated by the Trigeminal Nerve in a Child with Beckwith–Wiedemann Syndrome

et al. 2023

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About 90% of children diagnosed with classic BWS have macroglossia, and 40% of them are submitted to surgical tongue reduction. The purpose of our article is to present a case study of a 5-month-old child with BWS who was treated with an original therapy for stimulation of oral areas innervated by the trigeminal nerve. The therapy included stimulation of the upper and lower lip and muscles of the floor of the mouth. The treatment was provided by a therapist once a week. In addition, the child was stimulated every day at home by his mother. After 3 months, a significant improvement in oral alignment and function was achieved. Preliminary observations of therapy application for stimulation regions innervated by the trigeminal nerve in children with Beckwith–Wiedemann syndrome seem promising. The original therapy for stimulation of oral areas innervated by the trigeminal nerve is a good alternative to existing methods of surgical tongue reduction in children with BWS and macroglossia.

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Suppression of the nociceptive jaw-opening reflex by stimulation of the red nucleus

Cited by 9 publications

References 38 publications

Suppression of the swallowing reflex by stimulation of the red nucleus

Suppression of the swallowing reflex by stimulation of the red nucleus

Retracted: Rubral modulation of breathing

Application of Original Therapy for Stimulation of Oral Areas Innervated by the Trigeminal Nerve in a Child with Beckwith–Wiedemann Syndrome

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